Synthesis of supramolecular receptors for amino acid recognition

Abstract

The derivatives of 2,6-dihydroxyacetophenone [4]arene were synthesized via one-step in the presence of base catalyzed cyclocondensation reaction of equimolar volumes of different aliphatic aldehydes and 2,6-dihydroxyacetophenone. All the compounds were purified by column chromatography and characterized by 1 H-NMR Spectroscopy, 13 C-NMR Spectroscopy, IR Spectroscopy, and Mass spectrometry techniques. The compounds were provided with good yield and can be successfully useful for various amino acid detection because of the four ketone groups in 2,6-Dihydroxyaceto-phenone[4]arene were able to react with the amino group of amino acid to give a stable product formation. It was caused by the intermolecular hydrogen bonded between the two groups, ketone and carboxylic group of amino acid. This recognition of amino acid was carried out in UV-vis spectroscopic technique.

Resorcin[4]arene Schiff base derivatives: Synthesis, characterization, and extraction studies

“…The 2,6-dihydroxyacetophenone [4]arene derivatives (1a-h) were synthesized by following the previously published procedure described by our group. 35 Compounds 1a-h were the starting materials, which were condensed with benzylamine in chloroform to generate the Schiff base derivatives 2a-h (Scheme 1). The main purpose for preparing these resorcin [4]arene Schiff bases was for the recognition of anions and cations of toxic metals present in aqueous media.…”

“…The derivatives of 2,6-dihydroxyacetophenone [4]arene were synthesized by following our group's published procedure. 35 2,6-Dihydroxyacetophenone (0.500 g, 3.289 mmol) and the aliphatic aldehyde (3.289 mmol) in tetrahydrofuran (THF; 20 mL) was treated with NaOMe (0.1 g, 1.85 mmol) at room temperature. The reaction mixture was then heated at reflux with constant stirring for 72 h. After completion of the reaction, the mixture was cooled to room temperature and the solvent was evaporated under vacuum.…”

A versatile enrichment of functionalized calixarene as a facile sensor for amino acids

“…This sensing work was carried out using UV-vis spectroscopy, and all of the sensors observed the maximum value to be at $350 nm, which was increased to 390 nm after the addition of amino acids to the moiety (Figure 10). [87] In another example, Demirtas and colleagues developed a new calix [4]aza-crown ether cavity with a furfuryl and benzyl moiety (22).…”