Synthesis of taxoids 4. Novel and versatile methods for preparation of new taxoids by employing cis- or trans-phenyl glycidic acid

One‐pot synthesis of [11C]ureas via triphenylphosphinimines

“…For example, the application of resin-bound triphenylphosphinimines, 27 subjection of amines on solid support 31,32 to the intermediate [ 11 C]isocyanate, as well as the use of a wide range of other nucleophiles that can lead to compounds other than ureas (i.e. thiols, [33][34][35] alkynes, 36,37 or alcohols/acids [38][39][40][41] ). So, the present method generates great possibilities for the preparation of a large number of different 11 C-labeled compounds that can be prepared from […”

General and Recent Aspects of the Chemistry and Structure Activity Relationships of Taxoids

“…This was the case of the first semisynthesis of docetaxel 2 which have been prepared from a 13-cinnamoyl-10-deacetylbaccatrin III derivative [14]. More recently, a new synthesis of docetaxel using glycidic acids was reported [58]. Thus, the coupling reaction of (2R, 3R)-phenyl-glycidic acid with a protected derivative of 10-deacetylbaccatin III afforded the 13-O-acylated derivative 69 in excellent yield.…”

Convergent synthesis of cis-α,β-epoxy-carboxylic acids from 1-halo-2-trimethylsilyloxy-3-aza-4-phenyl-1,3-butadiene

“…Carboxylic acids bearing in a,bposition an oxirane ring functionality are, in fact, useful intermediates in the synthesis of biologically active compounds. They have recently found application in the synthesis of Taxol and Taxotere derivatives and the carboxy-acid functionality presents several advantages over the corresponding carboxy-ester in the coupling reaction of Bacchatin 10 and side chains, 24 adding extra value to their synthesis.…”