Synthesis of temperature/pH dual-responsive mesoporous silica nanoparticles by surface modification and radical polymerization for anti-cancer drug delivery

Porrang, Sahar; Rahemi, Nader; Davaran, Soodabeh; Mahdavi, Majid; Hassanzadeh, Belal

doi:10.1016/j.colsurfa.2021.126719

Cited by 30 publications

(21 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 21 As mentioned, other silica sources are inorganic materials, such as silicon tetrachloride, 22 , 23 olivine, 24 , 25 and sodium silicate solution. 15 , 26 , 27 Sodium silicate as an economical and available precursor can be an excellent source for the synthesis of silica-based nanoparticles. However, industrial production of sodium silicate requires a great deal of energy.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

“… 30 Therefore, the synthesis of sodium silicate from silica-rich industrial by-products is under scrutiny. 26 However, it is interesting to know that researchers concluded it was possible to obtain sodium silicate from natural sources such as materials that are considered agricultural waste or by-products such as rice husk, wheat husk, coffee husk, barley grass, corn cob, sugarcane bagasse, oil palm. 15 , 26 , 27 These plants, due to the absorption of silica in the soil by their roots, can be as productive, economic, and accessible precursors of silica nanoparticles.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

“…The presence of silanol groups on the surface of silica nanoparticles is one of their unique attributes making simple surface modification to create the desired functional groups on them. So MSNs can be functionalize with some functional silane precursors such as Vinyltrimethoxysilane (VTMO), 80 Vinyltriethoxysilane (VTES), 26 , 27 Aminopropyltriethoxysilane (APTES), 81 and 3-mercaptopropyltriethoxysilane (MPTS) 82 to create various type functional groups. The existence of MSNs with different types of functional groups has led to significant growth in various sciences such as catalysis, adsorption, separation, chromatography, chemical sensors, and bioscience.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

“…The various types of these systems were fabricated and investigated by researchers. Due to higher metabolism and inflammation 26 , 27 , 102 in tumor tissues, temperature-responsive systems were introduced. Poly (N-isopropyl acrylamide) (PNIPAAm), 26 , 27 paraffin wax, 103 and glycerophosphate 104 are the most commonly used temperature-sensitive materials for temperature-responsive nanocarriers synthesis.…”

Section: Nanocarriers Features In Drug Delivery and Cancer Therapymentioning

confidence: 99%

“…Due to higher metabolism and inflammation 26 , 27 , 102 in tumor tissues, temperature-responsive systems were introduced. Poly (N-isopropyl acrylamide) (PNIPAAm), 26 , 27 paraffin wax, 103 and glycerophosphate 104 are the most commonly used temperature-sensitive materials for temperature-responsive nanocarriers synthesis. The phase-transition temperatures of these materials are higher than the body temperature.…”

Section: Nanocarriers Features In Drug Delivery and Cancer Therapymentioning

confidence: 99%

See 4 more Smart Citations

How Advancing are Mesoporous Silica Nanoparticles? A Comprehensive Review of the Literature

Porrang¹,

Davaran²,

Rahemi³

et al. 2022

IJN

Self Cite

View full text Add to dashboard Cite

The application of mesoporous silica nanoparticles (MSNs) is ubiquitous in various sciences. MSNs possess unique features, including the diversity in manufacturing by different synthesis methods and from different sources, structure controllability, pore design capabilities, pore size tunability, nanoparticle size distribution adjustment, and the ability to create diverse functional groups on their surface. These characteristics have led to various types of MSNs as a unique system for drug delivery. In this review, first, the synthesis of MSNs by different methods via using different sources were studied. Then, the parameters affecting their physicochemical properties and functionalization have been discussed. Finally, the last decade’s novel strategies, including surface functionalization, drug delivery, and cancer treatment, based on the MSNs in drug delivery and cancer therapy have been addressed.

show abstract

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Section: Nanocarriers Features In Drug Delivery and Cancer Therapymentioning

confidence: 99%

Section: Nanocarriers Features In Drug Delivery and Cancer Therapymentioning

confidence: 99%

See 3 more Smart Citations

How Advancing are Mesoporous Silica Nanoparticles? A Comprehensive Review of the Literature

Porrang¹,

Davaran²,

Rahemi³

et al. 2022

IJN

Self Cite

View full text Add to dashboard Cite

show abstract

Development of Chitosan‐Coated Graphene Oxide and Iron Oxide Nanocomposites for Targeted Delivery of Camptothecin to Liver Cancer Cells

Sukumar,

Bharathi,

Hirad

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Innovative drug delivery platforms for selective, regulated, and sustained release of anticancer drugs are crucial in cancer treatment. This study presents nanoparticles developed from chitosan (CS), graphene oxide (GO), and magnetite (Fe3O4), and their nanocomposites, to enhance the loading and release efficiency of camptothecin (CPT). Nanostructures were characterized using imaging microscopy, FT‐IR, and X‐ray diffraction, with an average crystallite size of 5.5 nm. Camptothecin binding proportions were 70% for CS, 81% for CS@Fe3O4, 58% for CS@GO, and 74% for CS@GO/Fe3O4. At pH 5.0, CPT release ratios were 87%, 80%, 88%, and 90%, respectively, and at pH 7.4, 84%, 72%, 89%, and 87%. Cytotoxicity was assessed using the MTT assay against HepG2 and SMMC‐7721 cancer cells. CPT‐CS@GO/Fe3O4 exhibited the highest survival at 5 µM and 12.5 µM concentrations, indicating it as the most effective nanocarrier for camptothecin delivery. The study demonstrates CS@GO/Fe3O4's potential as a superior drug delivery system.

show abstract

Smart polymer grafted silica based drug delivery systems

Shah

Jadhav

Belekar

et al. 2022

Polymers for Advanced Techs

View full text Add to dashboard Cite

Smart polymers are a special class of polymers, which respond to the various external stimuli by changing their properties. Recent developments in synthetic polymer chemistry have provided the possibility of designing and synthesis of various new stimuli‐responsive polymers. These stimuli‐responsive polymers can be used to prepare smart drug delivery systems (DDS) by grafting them on various nanomaterials. The main aim of this review is to present collective information on various stimuli‐responsive polymers grafted on silica nanoparticles for the preparation of smart DDS. The stimuli covered are pH, temperature, redox, reactive oxygen species (ROS), glucose concentration, enzymes, magnetic field, and so forth. The structures of various stimuli‐responsive polymers are shown with their relevance to the preparation of smart DDS. The crucial roles of macromolecular design and synthesis of smart polymers in the development of stimuli‐responsive DDS are discussed with examples from literature and the challenges that still exist in this area of research are presented.

show abstract

Synthesis of temperature/pH dual-responsive mesoporous silica nanoparticles by surface modification and radical polymerization for anti-cancer drug delivery

Cited by 30 publications

References 47 publications

How Advancing are Mesoporous Silica Nanoparticles? A Comprehensive Review of the Literature

How Advancing are Mesoporous Silica Nanoparticles? A Comprehensive Review of the Literature

Development of Chitosan‐Coated Graphene Oxide and Iron Oxide Nanocomposites for Targeted Delivery of Camptothecin to Liver Cancer Cells

Smart polymer grafted silica based drug delivery systems

Contact Info

Product

Resources

About