Synthesis of Tetra‐, Hexa‐, and Octanuclear Organozinc Ring Systems

Insertion Reactions of Heterocumulenes into Zn−C Bonds: Synthesis and Structural Characterization of Multinuclear Zinc Amidate Complexes

“…Zinc alkoxides, for instance, have long been known to adopt dimeric and tetrameric structures in the solid state, whereas trimeric derivatives have only very recently been reported . The same is true for zinc carboxylates and carbamates, which have also been structurally characterized to some extent . Moreover, Mitzel, Redshaw, Lewiński, and others have reported in the past decade on the synthesis of comparable zinc complexes using 1,2-double-donor systems such as peroxides, and hydrazides as well as hydroxylamides .…”

Synthesis of Trimeric Organozinc Compounds and their Subsequent Reaction with Oxygen

“…Since then, the field has undergone a renaissance, owing to re‐examination of the oxidation of R 2 Zn compounds through the contributions of Lewiński et al. and a handful of other groups . A study reported by Lewiński et al.…”

“…It is known that the structure of organozinc compounds can be enormously varied, including multinuclear rings or cubanes, and DFT studies have even considered cyclic and roof‐like structures (Figures 1 a and b) …”

Cellular uptake studies of two hexanuclear, carboxylate bridged, zinc ring structures using fluorescence microscopy

“…6 Herein, we turn our attention to organozinc chemistry and find that use of these same Schiff-base ligands with the zinc reagent [(C 6 F 5 ) 2 ZnÁtoluene] affords hexanuclear zinc macrocycles 2a and 2b, very different in structure to I; ring systems containing multiple zinc centres remain rare. 7 The emission of these organozinc systems has allowed us to explore the cellular uptake into CHO cells. We also report herein cytotoxicity studies on these zinc ring systems and the parent Schiff base ligands for different cell types CHO, Hela, THP-1 and HL60.…”