Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity

Shimbashi, Akiko; Tsuchiya, Ayako; Imoto, Masaya; Nishiyama, Shigeru

doi:10.1016/j.bmcl.2004.10.034

Cited by 7 publications

(1 citation statement)

References 33 publications

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“…On the other hand, the naphthalene-type analog of vitamin K 3 11 had Cdc25A phosphatase-inhibitory activity equal to IC 50 0.4 µM [31]. In addition, naphthoquinone derivatives, containing malonic 12 or carboxylic acids 13 groups were introduced to mimic the role of phosphate moieties of Cdk complexes.…”

Section: Cdc25 Inhibitors Based On the Quinoid Structurementioning

confidence: 99%

A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors

Abdelwahab¹,

El‐Sawy

Hanna

et al. 2022

Molecules

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Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. In the last two decades, the interest in this subject has considerably increased and many publications have been launched concerning this issue. An overview is constructed based on data analysis of the results of the previous publications covering the years from 1992 to 2021. Thus, the main objective of the current review is to report the chemical structures of Cdc25s inhibitors and answer the question, how to design an inhibitor with better efficacy and lower toxicity?

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Section: Cdc25 Inhibitors Based On the Quinoid Structurementioning

confidence: 99%

A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors

Abdelwahab¹,

El‐Sawy

Hanna

et al. 2022

Molecules

View full text Add to dashboard Cite

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Synthesis of the Naphthalene‐Derived Inhibitors Against Cdc25A Dual‐Specificity Protein Phosphatase and Their Biological Activity.

et al. 2005

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Quinones Q 0910Synthesis of the Naphthalene-Derived Inhibitors Against Cdc25A Dual-Specificity Protein Phosphatase and Their Biological Activity. -A variety of naphthalene and naphthoquinone derivatives are synthesized and evaluated for their in vitro Cdc25A phosphatase-inhibitory activity. SAR studies indicate that the naphthoquinone core with a methoxy substituent, instead of a methylamino group as in natural pyranonaphthoquinones, is an important factor to show high activity of phosphatase inhibition. -(SHIMBASHI, A.; TSUCHIYA, A.; IMOTO, M.; NISHIYAMA*, S.; Bioorg. Med. Chem. Lett. 15 (2005) 1, 61-65; Dep. Chem., Fac. Sci. Technol., Keio Univ., Kohoku, Yokohama 223, Japan; Eng.) -R. Langenstrassen 15-088

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