Synthesis of thermoresponsive composite hydrogel from Pluronic F127 reinforced by oil palm empty fruit bunches-extracted cellulose for silver sulfadiazine drug delivery

Al-Rajabi, Maha Mohammad; Teow, Yeit Haan

doi:10.1016/j.scp.2022.100939

Cited by 9 publications

(5 citation statements)

References 63 publications

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“…The effect of hydrogel swelling behavior on drug release was assessed. The swelling ratios for Dual Dox Fibre25@cGel and Dual Dox Fibre100@cGel were found to increase with time initially and plateau after day 1 (Table S4), which were consistent with previous reports on similar types of Pluronic and cellulose composite hydrogel systems . In spite of the hydrogel swelling, we observed only a marginal decrease in Dox released from the Dual Dox Fibre@cGels compared to free Dual Dox Fibres (Figures C and C), which could be attributed to the interactions between the released Dox and cGel components, as previously discussed.…”

Section: Resultssupporting

confidence: 90%

Free-Standing Hierarchically Porous Silica Nanoparticle Superstructures: Bridging the Nano- to Microscale for Tailorable Delivery of Small and Large Therapeutics

Palvai,

Kpeglo,

Newham

et al. 2024

ACS Appl. Mater. Interfaces

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Nanoscale colloidal self-assembly is an exciting approach to yield superstructures with properties distinct from those of individual nanoparticles. However, the bottom-up self-assembly of 3D nanoparticle superstructures typically requires extensive chemical functionalization, harsh conditions, and a long preparation time, which are undesirable for biomedical applications. Here, we report the directional freezing of porous silica nanoparticles (PSiNPs) as a simple and versatile technique to create anisotropic 3D superstructures with hierarchical porosity afforded by microporous PSiNPs and newly generated meso-and macropores between the PSiNPs. By varying the PSiNP building block size, the interparticle pore sizes can be readily tuned. The newly created hierarchical pores greatly augment the loading of a small molecule-anticancer drug, doxorubicin (Dox), and a large macromolecule, lysozyme (Lyz). Importantly, Dox loading into both the microand meso/macropores of the nanoparticle assemblies not only gave a pore size-dependent drug release but also significantly extended the drug release to 25 days compared to a much shorter 7 or 11 day drug release from Dox loaded into either the micro-or meso/macropores only. Moreover, a unique temporal drug release profile, with a higher and faster release of Lyz from the larger interparticle macropores than Dox from the smaller PSiNP micropores, was observed. Finally, the formulation of the Dox-loaded superstructures within a composite hydrogel induces prolonged growth inhibition in a 3D spheroid model of pancreatic ductal adenocarcinoma. This study presents a facile modular approach for the rapid assembly of drug-loaded superstructures in fully aqueous environments and demonstrates their potential as highly tailorable and sustained delivery systems for diverse therapeutics.

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Section: Resultssupporting

confidence: 90%

Free-Standing Hierarchically Porous Silica Nanoparticle Superstructures: Bridging the Nano- to Microscale for Tailorable Delivery of Small and Large Therapeutics

Palvai,

Kpeglo,

Newham

et al. 2024

ACS Appl. Mater. Interfaces

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“…AL-Rajabi and Teow developed a sustainable synthesis method for a thermoresponsive Pluronic F127 composite hydrogel reinforced with cellulose taken from empty fruit clusters of oil palm for silver sulfadiazine drug delivery. Their study demonstrated that the developed material from rich agricultural biomass is sustainable, environmentally friendly, and cost-effective for being used as DDSs [78].…”

Section: Cellulosementioning

confidence: 99%

An Overview of Biopolymers for Drug Delivery Applications

Opriș,

Mormile,

Lung

et al. 2024

Applied Sciences

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Nowadays, drug delivery has an important role in medical therapy. The use of biopolymers in developing drug delivery systems (DDSs) is increasingly attracting attention due to their remarkable and numerous advantages, in contrast to conventional polymers. Biopolymers have many advantages (biodegradability, biocompatibility, renewability, affordability, and availability), which are extremely important for developing materials with applications in the biomedical field. Additionally, biopolymers are appropriate when they improve functioning and have a number of positive effects on human life. Therefore, this review presents the most used biopolymers for biomedical applications, especially in drug delivery. In addition, by combining different biopolymers DDSs with tailored functional properties (e.g., physical properties, biodegradability) can be developed. This review summarizes and provides data on the progress of research on biopolymers (chitosan, alginate, starch, cellulose, albumin, silk fibroin, collagen, and gelatin) used in DDSs, their preparation, and mechanism of action.

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“…PNIPAM-based thermal response hydrogel was reported that had good antibacterial activity, and biocompatibility, and could assist wound closure and promote wound healing [ 181 ]. In another study, thermos-responsive hydrogels were synthesized using Pluronic F127 and cellulose, which showed good antimicrobial properties [ 182 ]. In addition to the above two intelligent response types, enzyme response and oxidation restore response also reflected good bacteriostatic effects and the performance of promoting wound recovery [ 183 , 184 ].…”

Section: Antibacterial Treatments Based On Hydrogelsmentioning

confidence: 99%

Advances in preparation and application of antibacterial hydrogels

Tang,

Xu,

Wang

et al. 2023

J Nanobiotechnol

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Bacterial infections, especially those caused by drug-resistant bacteria, have seriously threatened human life and health. There is urgent to develop new antibacterial agents to reduce the problem of antibiotics. Biomedical materials with good antimicrobial properties have been widely used in antibacterial applications. Among them, hydrogels have become the focus of research in the field of biomedical materials due to their unique three-dimensional network structure, high hydrophilicity, and good biocompatibility. In this review, the latest research progresses about hydrogels in recent years were summarized, mainly including the preparation methods of hydrogels and their antibacterial applications. According to their different antibacterial mechanisms, several representative antibacterial hydrogels were introduced, such as antibiotics loaded hydrogels, antibiotic-free hydrogels including metal-based hydrogels, antibacterial peptide and antibacterial polymers, stimuli-responsive smart hydrogels, and light-mediated hydrogels. In addition, we also discussed the applications and challenges of antibacterial hydrogels in biomedicine, which are expected to provide new directions and ideas for the application of hydrogels in clinical antibacterial therapy.

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Synthesis of thermoresponsive composite hydrogel from Pluronic F127 reinforced by oil palm empty fruit bunches-extracted cellulose for silver sulfadiazine drug delivery

Cited by 9 publications

References 63 publications

Free-Standing Hierarchically Porous Silica Nanoparticle Superstructures: Bridging the Nano- to Microscale for Tailorable Delivery of Small and Large Therapeutics

Free-Standing Hierarchically Porous Silica Nanoparticle Superstructures: Bridging the Nano- to Microscale for Tailorable Delivery of Small and Large Therapeutics

An Overview of Biopolymers for Drug Delivery Applications

Advances in preparation and application of antibacterial hydrogels

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