Drug delivery is a difficult task in the field of dermal therapeutics, particularly in the treatment of burns, wounds, and skin diseases. Conventional drug delivery mediums have some limitations, including poor retention on skin/wound, inconvenience in administration, and uncontrolled drug release profile. Hydrogels able to absorb large amount of water and give a spontaneous response to stimuli imposed on them are an attractive solution to overcome the limitations of conventional drug delivery media. The objective of this study is to explore a green synthesis method for the development of thermo-responsive cellulose hydrogel using cellulose extracted from oil palm empty fruit bunches (OPEFB). A cold method was employed to prepare thermo-responsive cellulose hydrogels by incorporating OPEFB-extracted cellulose and Pluronic F127 (PF127) polymer. The performance of the synthesized thermo-responsive cellulose hydrogels were evaluated in terms of their swelling ratio, percentage of degradation, and in-vitro silver sulfadiazine (SSD) drug release. H8 thermo-responsive cellulose hydrogel with 20 w/v% PF127 and 3 w/v% OPEFB extracted cellulose content was the best formulation, given its high storage modulus and complex viscosity (81 kPa and 9.6 kPa.s, respectively), high swelling ratio (4.22 ± 0.70), and low degradation rate (31.3 ± 5.9%), in addition to high t50% value of 24 h in SSD in-vitro drug release to accomplish sustained drug release. The exploration of thermo-responsive cellulose hydrogel from OPEFB would promote cost-effective and sustainable drug delivery system with using abundantly available agricultural biomass.

Pretreatment of raw feed water is an essential step for proper functioning of a reverse osmosis (RO) desalination plant as it minimizes the risk of membrane fouling. Conventional pretreatment methods have drawbacks, such as the potential of biofouling, chemical consumption, and carryover. Non-conventional membrane-based pretreatment technologies have emerged as promising alternatives. The present review focuses on recent advances in MF, UF, and NF membrane pretreatment techniques that have been shown to be effective in preventing fouling as well as having low energy consumption. This review also highlights the advantages and disadvantages of polymeric and ceramic membranes. Hybrid technologies, which combine the benefits of conventional and non-conventional methods or different membranes, are also discussed as a potential solution for effective pretreatment. The literature that has been analyzed reveals the challenges associated with RO pretreatment, including the high cost of conventional pretreatment systems, the difficulty of controlling biofouling, and the production of large volumes of wastewater. To address these challenges, sustainable hybrid strategies for ceramic membrane-based systems in RO pretreatment are proposed. These strategies include a thorough assessment of the source water, removal of a wide range of impurities, and a combination of methods such as adsorption and carbon dioxide with a low amount of antiscalants. Furthermore, the suggestion of incorporating renewable energy sources such as solar or wind power can help reduce the environmental impact of the system. A pilot study is also recommended to overcome the difficulties in scaling ceramic systems from laboratory to industrial scale. The review also emphasizes the importance of conducting an effective assessment to suggest a treatment for the brine if needed before being discharged to the environment. By following this framework, sustainable, energy-efficient, and effective solutions can be recommended for pretreatment in desalination systems, which can have significant implications for water scarcity and environmental sustainability.

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