“…Specifically, we aim to determine if rigid mannose-coated polymers with a cyclic topology, denoted as c-PNB X -TEG-Man, can compete with their linear counterparts, l-PNB X -TEG-Man, possessing similar DP n . To the best of our knowledge, such a comparison has only been provided in the literature for flexible glycopolymers. ,− These polymers are obtained through CuAAc cyclization of their linear analogs, which are terminated with azide and alkyne groups. If flexible glycomacrocycles were shown to give higher affinity constant on a panel of human innate immune lectins (DC-SIGN, MBL, SP-D, dectin-2, and mincle) compared to their linear analogues, other sets of cyclic glycopolymers showed significantly weaker interactions with their model lectins (ConA and RCA120). , Thus, topological effects of polymeric scaffold on the binding affinity of specific targets remain unpredictable.…”