Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

Li, Hongguang; El-Dakdouki, Mohammad H.; Zhu, David C.; Abela, George S.; Huang, Xuefei

doi:10.1039/c2cc17852d

Cited by 60 publications

(30 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro in HeLa cells, β-CD/chitosan complexes exhibited an enhanced capacity to efflux cholesterol from cell membranes as compared to β-CD alone and the addition of CEEP to the β-cyclodextrin/chitosan complex double this efficacy of cholesterol extraction from cell membranes [52]. In 2012, Li and colleagues [51] conjugated carboxy-methyl-β-CD with superparamagnetic ion oxyde nanoparticles exhibiting a selective binding to CCs with the aim to further use as a detection tool in MRI for atherosclerosis.…”

Section: Cyclodextrins and Atherosclerosismentioning

confidence: 99%

“…This will be more extensively discussed later in this review for atherosclerosis and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases (Figure 2). In addition, CDs can be used as a carrier enabling the selective binding to biomolecules of interest, as reported for example for cholesterol crystal detection in atherosclerosis ( [51], later discussed in this review).…”

Section: Cds As Drug Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

et al. 2016

View full text Add to dashboard Cite

Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism. Therefore, innovative pharmacological approaches aiming at counteracting cholesterol imbalance display promising therapeutic potential. However, these approaches need to take into account the existence of biological barriers such as intestinal and blood-brain barriers which participate in the organ homeostasis and are major defense systems against xenobiotics. Interest in cyclodextrins (CDs) as medicinal agents has increased continuously based on their ability to actively extract lipids from cell membranes and to provide suitable carrier system for drug delivery. Many novel CD derivatives are constantly generated with the objective to improve CD bioavailability, biocompatibility and therapeutic outcomes. Newly designed drug formulation complexes incorporating CDs as drug carriers have demonstrated better efficiency in treating cardiovascular and neurodegenerative diseases. CD-based therapies as cholesterol-sequestrating agent have recently demonstrated promising advances with KLEPTOSE ® CRYSMEB in atherosclerosis as well as with the 2-hydroxypropyl-β-cyclodextrin (HPβCD) in clinical trials for Niemann-Pick type C disease. Based on this success, many investigations evaluating the therapeutical beneficial of CDs in Alzheimer's, Parkinson's and Huntington's diseases are currently on-going.

show abstract

Section: Cyclodextrins and Atherosclerosismentioning

confidence: 99%

Section: Cds As Drug Delivery Systemsmentioning

confidence: 99%

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Thus, a biological solvent that can accelerate the dissolving of CCs in conjunction with lowering the blood cholesterol levels may represent an opportunity to improve cerebrovascular health in this at-risk population. Recent discovery of β-cyclodextrin conjugated superparamagnetic nanoparticles [37] that selectively bind to CCs will be a vital diagnostic tool for imaging of CCs in CC-related neurological diseases such as atherosclerosis. Importantly, our observation of CC formation in animal model of atherosclerosis was validated in the alcohol environment in human subjects, which has a significant clinical relevance to the health of chronic alcohol consumers.…”

Section: Discussionmentioning

confidence: 99%

Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions

Abdul-Muneer

Alikunju

Mishra

et al. 2017

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Epidemiological studies showed a strong association between alcoholism and incidence of stroke, for which the underlying causative mechanisms remain to be understood. Here we found that infiltration of immune cells and deposition of cholesterol at the site of brain artery/capillary injury induced atherosclerosis in chronic alcohol (ethanol) consumption in the presence or absence of high-fat diet. Conversion of cholesterol into sharp edges of cholesterol crystals (CCs) in alcohol intake was key to activation of NLRP3 inflammasome, induction of cerebral atherosclerosis, and development of neuropathy around the atherosclerotic lesions. The presence of alcohol was critical for the formation of CCs and development of the neuropathology. Thus, we observed that alcohol consumption elevated the level of plasma cholesterol, deposition and crystallization of cholesterol, as well as activation of NLRP3 inflammasome. This led to arteriole or capillary walls thickening and increase intracranial blood pressure. Distinct neuropathy around the atherosclerotic lesions indicated vascular inflammation as an initial cause of neuronal degeneration. We demonstrated the molecular mechanisms of NLRP3 activation and downstream signaling cascade event in primary culture of human brain arterial/capillary endothelial cells in the setting of dose-/time-dependent effects of alcohol/CCs using NLRP3 gene silencing technique. We also detected CCs in blood samples from alcohol users, which validated the clinical importance of the findings. Finally, combined therapy of acetyl-l-carnitine and Lipitor® prevented deposition of cholesterol, formation of CCs, activation of NLRP3, thickening of vessel walls, and elevation of intracranial blood pressure. We conclude that alcohol-induced accumulation and crystallization of cholesterol activates NLRP3/caspase-1 in the cerebral vessel that leads to early development of atherosclerosis.

show abstract

“…Multiple epitopes of the same ligand exposed and a presentation in a three-dimensional format may result in enhanced affinities of the polysaccharide for its biological target 7. As an example, Li and colleagues designed magnetic nanoparticles with multiple copies of cyclodextrin functionalizing the surface in order to enable simultaneous interaction with many cholesterol molecules, leading to high affinity binding with cholesterol for MRI detection purposes 50. In fact, nanosystems may act as platform amplifying the weak affinities of polysaccharide ligands with biological molecules of interest.…”

Section: Structure-function Of Polysaccharides and Features Of Nanopamentioning

confidence: 99%

Polysaccharide Nanosystems for Future Progress in Cardiovascular Pathologies

Silva¹,

Letourneur²,

Chauvierre³

2014

Theranostics

View full text Add to dashboard Cite

Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nanosystems. Polysaccharide-based nanosystems may be designed for interacting in several biological processes. In particular, the atherothrombotic pathology is highly concerned by polysaccharide-mediated recognition. Atherothrombotic diseases, regardless of the anatomical localization, remain the main causes of morbidity and mortality in the industrialized world. This review intends to provide an overview on polysaccharide-based nanosystems as drug delivery systems and targeted contrast agents for molecular imaging with an emphasis on the treatment and imaging of cardiovascular pathologies.

show abstract

Synthesis of β-cyclodextrin conjugated superparamagnetic iron oxide nanoparticles for selective binding and detection of cholesterol crystals

Cited by 60 publications

References 19 publications

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases

Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions

Polysaccharide Nanosystems for Future Progress in Cardiovascular Pathologies

Contact Info

Product

Resources

About