Synthesis, physical characterization and biological evaluation of Schiff base M(II) complexes

Alias, M. F. A.; Kassum, Huda; Shakir, Carolin

doi:10.1016/j.jaubas.2013.03.001

Cited by 39 publications

(48 citation statements)

References 14 publications

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“…On complexation this band was shifted in the lower region of 1619-1652 cm -1 , respectively [15]. Further indication for metal ions coordinated through the nitrogen, oxygen and chlorine atoms is the appearance of the new υ(M-O), υ(M-N) and υ(M-Cl) bands in the region of 612-636 cm −1 , 485-494 cm −1 and 331-386 cm -1 correspondingly, these results were good agreement with earlier reports [16,17]. Table 2.…”

Section: Ir Spectra:-supporting

confidence: 92%

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.

Rajendran¹,

Govindharaji²,

Chozhanathmisra³

et al. 2017

IJAR

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A series of homo-binuclear Cu(II), Co(II), Ni(II) and Mn(II) metal complexes of Schiff base which was derived from 2,6-diaminopyridine and glyoxal have been synthesized. The plausible geometry of Schiff base and its binucleating metal complexes were examined by means of elemental and thermal analysis, molar conductance, 1 HNMR, UV-Vis, IR, ESR and mass spectra. From the spectral studies, a six coordinate environment around the metal dimers was confirmed. Both of the Schiff base and its metal complexes were tested for their in vitro antimicrobial activities against some bacterial and fungal strains. Schiff base and its metal complexes were also investigated for its cytotoxic effect against human breast cancer (MCF7) cell lines and it was observed that homo-binuclear Cu(II) and Co(II) complexes showed a good antitumor activity. The antioxidant activity was measured by DPPH method and the result showed that few metal complexes have been more potential activity. [7]. Recently, abundant research on macrocyclic complexes have been focused on species containing the first-row transition metal Schiff base [8]. Furthermore, pyridine based Schiff bases were a significant class of bioactive compounds in medicinal and pharmaceutical fields [9,10]. The above results encouraged making the present study that deals with the synthesis and characterization of heterocyclic homo-binuclear Schiff base complexes derived from 2,6-diaminopyridine and glyoxal containing a NO donor system with some divalent metal ions, namely Cu(II), Co(II), Ni(II) and Mn(II) along with their better biological activity due to their potentially useful properties.

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Section: Ir Spectra:-supporting

confidence: 92%

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.

Rajendran¹,

Govindharaji²,

Chozhanathmisra³

et al. 2017

IJAR

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“…On the other hand, the binding tendency of the organic bases toward the Co(III) centre is almost compatible with their steric rather than their basicity character when the size of acids was increased [41]. The basic constants, K b , of the donor amines applied in this study are increased according to the trend: Im, 4-MeIm, BzIm have the pK a = 6.73, 6.92, 7.96 [42], the formation constants for these bases with [Co(cd3OMesalMeen)(PBu 3 + complexes are decreased with increasing steric hindrance of the donor bases (Table 1):…”

Section: The Effect Of the Cyclic Amine Donorsmentioning

confidence: 84%

“…For a long time tetradentate Schiff base complexes of transition metal ions have attracted many researchers interest in the field of coordination chemistry [1][2][3][4]. Though a large number of papers have appeared on metal complexes with Schiff base derived from aromatic aldehydes and substituted amines with N 4 and N 2 O 2 coordination sphere [5][6][7][8], only few publications exist on Schiff bases containing sulfur donor ligands.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, physical characterization, antibacterial activity and thermodynamic studies of five coodrdinate cobalt(III) Schiff base complexes

Esmaielzadeh¹,

Zare²,

Azimian³

2016

Bull. Chem. Soc. Eth.

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ABSTRACT. Some five-coordinated cobalt(III) complexes were synthesized and characterized using elemental analysis, 1 H NMR and IR spectra. The formation constants and the thermodynamic parameters were measured spectrophotometrically for the 1:1 adduct formation of [Co(Chel)(PBu3)]ClO4.H2O where Chel = cd3OMesalen, cd4OMesalen, cd5OMesalen: methyl-2-{[1-methyl-2-(2-hydroxy-3-, 4-, 5-methoxyphenyl)methylidynenitrilo]ethyl}amino-1-cyclopentene-dithiocarboxylate, as acceptors, with some linear and cyclic amines as donors, in different solvents at constant ionic strength (I = 0.1 M NaClO4), and at various temperatures (T = 283-313 K). The results revealed that the formation constants of the Co(III) Schiff base complexes toward a given amines donor are as follow:The trend of the formation constants of the donors (amines) toward a given cobalt(III) complex is as follow: Im > 4-MeIm > BzIm and n-butylamine > sec-butylamine > tert-butylamine. Also the effect of the solvents on the formation constants of a given cobalt(III) Schiff base complex toward a given donor are as follow: CH3CN > DMF > EtOH. The ligands and their cobalt complexes have been screened for their antibacterial activities. All the free Schiff base ligands exhibit higher antibacterial activity than the cobalt(III) complexes.

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“…10 -3 M solutions at 25±1 °C of the complexes in DMF were measured by means of a Jenway 4310 conductivity meter and a diptype cell with a platinized electrode. 1 H NMR spectra were acquired on Bruker Avance DPX 250 MHz instruments.…”

Section: Methodsmentioning

confidence: 99%

“…Schiff bases as versatile organic blockers have recently attracted great attention due to their preparative accessibilities, molecular architectures and varied denticities. 1,2 This compounds with strong donor atom are excellent in catalysis and biological replication due to their strong coordination abilities with metal ions. 3 There are several reports on metal complexes such as Ni(II), Cu(II), Co(II) and Sn(IV) of the Schiff base ligands that have a variety of applications including biochemical reactions and biological regulators, 4,5 clinical, 6,7 analytical 8,9 and industrial uses in addition to their important roles in enhancing the solubility and stability of homogeneous or heterogeneous catalysts.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Spectral Studies, Antibacterial Evaluation, Thermodynamics and DFT Calculations of Dimethyltin(IV) Dichloride Schiff Base

Esmaielzadeh

Shekoohi

Sharif-Mohammadi

et al. 2015

ACSi

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Sn NMR, IR and mass spectroscopy. IR spectral data show that the fifth coordination position of tin atom is occupied by an oxygen atom of Schiff base ligands. In the light of titled techniques, trigonal bipyramidal geometry around the tin atom is proposed for the synthesized complexes. The in vitro antibacterial activities of the complexes against Staphylococcus aureus and Escherichia Coli have been studied. It was found that they possess significant antibacterial activity. Also, DFT/B3LYP method was used to analyze the electronic structures and study of the geometries. The thermodynamic formation constants of the complexes were determined spectrophotometrically at 25 °C in DMF solvent.

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Synthesis, physical characterization and biological evaluation of Schiff base M(II) complexes

Cited by 39 publications

References 14 publications

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.

SYNTHESIS, SPECTROSCOPIC, ANTICANCER, ANTIMICROBIAL AND ANTIOXIDANT STUDIES OF HOMO-BINUCLEAR Cu(II), Co(II), Ni(II) AND Mn(II) COMPLEXES WITH POLYDENTATE SCHIFF BASE LIGAND.

Synthesis, physical characterization, antibacterial activity and thermodynamic studies of five coodrdinate cobalt(III) Schiff base complexes

Synthesis, Characterization, Spectral Studies, Antibacterial Evaluation, Thermodynamics and DFT Calculations of Dimethyltin(IV) Dichloride Schiff Base

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