Synthesis, spectral, antioxidant, in vitro cytotoxicity activity and thermal analysis of Schiff base metal complexes with 2,2′-Bipyridine-4,4′-dicarboxylic acid as co-ligand

Mahadevi, Pichandi; Sumathi, S.; Metha, Alka; Singh, Jyoti

doi:10.1016/j.molstruc.2022.133669

Cited by 25 publications

(3 citation statements)

References 50 publications

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“…49 The complex containing cobalt and [2,2 0 -bipyridine]-4,4 0 -dicarboxylic acid was reported with anticancer activity against MCF-7 cancer cell. 50 The complex containing ruthenium and [2,2 0 -bipyridine]-4,4 0 -dicarboxylic with antioxidant activity, DNA/protein interaction and cytotoxicity against HCT-15, HeLa, SKOV3, MCF7 and SKMel2 cell lines is another example of the biological activity of [2,2 0 -bipyridine]-4,4 0 -dicarboxylic acid. 51 As mentioned, molybdenum and [2,2 0 -bipyridine]-4,4 0dicarboxylic acid have a high ability in biological activities such as antibacterial, antifungal and anticancer.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis, characterization, and in vitro biological evaluation of a novel nanocomposite using molybdenum and [2,2′-bipyridine]-4,4′-dicarboxylic acid

J. Saadh,

N.A. Jafar,

Altalbawy

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis, characterization, and in vitro biological evaluation of a novel nanocomposite using molybdenum and [2,2′-bipyridine]-4,4′-dicarboxylic acid

J. Saadh,

N.A. Jafar,

Altalbawy

et al. 2024

RSC Adv.

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“…Schiff bases known as imines or azomethines form by the condensation reaction of a primary amine and an aldehyde or ketone (29,30). Over the past years, antibacterial, antifungal, anticancer, antioxidant, antiviral activities of Schiff bases have been reported (31)(32)(33)(34)(35)(36)(37). The advantage of Schiff bases for the application of sonophotodynamic studies is the conjugation capability of them due to donor lone electron pairs on nitrogen atom (38,39).…”

Section: Introductionmentioning

confidence: 99%

Comparing Singlet Oxygen Generation of Schiff Base Substituted Novel Silicon Phthalocyanines by Sonophotochemical and Photochemical Applications

Ünlü

Atmaca

Elmalı

et al. 2023

Photochem & Photobiology

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Although the sonophotodynamic method has an effective therapeutic outcome for anticancer treatment compared with the photodynamic method, there are not enough related studies in the literature and this study aims to contribute to the development of sonophotodynamic studies. For this purpose, the Schiff base substituted silicon phthalocyanines were designed and synthesized as effective sensitizer candidates and the photophysicochemical and sonophotochemical features of the phthalocyanines were examined to increase singlet oxygen efficiency. The calculated ΦΔ values indicate that the contribution of substituent groups improved the production of singlet oxygen compared with silicon (IV) phthalocyanine dichloride (SiPcCI2) and also the sonophotochemical applications increased the singlet oxygen yields. The ΦΔ values (ΦΔ = 0.76 for axially bis‐{4‐[(E)‐(pyridin‐3‐ylimino)methyl]phenol} substituted silicon (IV) phthalocyanine (2a), 0.68 for axially bis‐4‐[(E)‐{[(pyridin‐3‐yl)methyl]imino}methyl]phenol substituted silicon (IV) phthalocyanine (2b) in photochemical study) reached to ΦΔ = 0.98 for 2a, 0.94 for 2b in sonophotochemical study. This article will enrich the literature on increasing singlet oxygen yield.

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“…The effectiveness of the drugs is declining daily as a result of the incorrect, prolonged, and widespread use of antibiotics, which has serious health consequences. The rise in bacterial resistance in recent years has made it a key priority for scientists to find innovative antibacterial drugs [16][17][18][19]. In this paper, new Schiff bases based on 3,3-diphenyl-2,3-dihydro-1H-inden-1-one and (thio)/carbohydrazone were obtained by reaction of 3,3-diphenyl-2,3-dihydro-1H-inden-1-one -βthiocarbohydrazone with isatin in the presence of glacial acetic acid under reflux in ethanol.…”

Section: Introductionmentioning

confidence: 99%

N′-((E)-3,3-Diphenyl-2,3-Dihydro-1H-Inden-1-Ylidene)-2-((Z)-2-Oxoindolin-3-Ylidene)Hydrazine-1-Carbothiohydrazide Ligand and Its Complexes: Spectroscopic, Molecular Orbital, Molecular Docking, Structural Study and Antimicrobial Activity

Zayed,

El-Sayed,

Albalawi

et al. 2023

Preprint

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New Schiff base ofN'-((E)-3,3-diphenyl-2,3-dihydro-1H-inden-1-ylidene)-2-((Z)-2-oxoindolin-3-ylidene)hydrazine-1-carbothiohydrazide (HL) and its Co(II),Ni(II), Fe(III), Cu(II), Cd(II), Zn(II) and Mn(II) complexes were created, isolated, and characterized by analytical analysis in good yields of 60 to 90%, UV–Vis, magnetic measurements, molar conductivity, and FT-IR. Additionally, mass spectrometry was used to examine the new ligand complexes' structural characteristics.1H NMR spectroscopy and elemental analysis. Depending on the electronic spectra and magnetic susceptibility measurements, these complexes are predicted to have octahedral molecular geometry. As an example, the quantum chemical properties, bond lengths, and bond angles were discussed. The structural formula for the examined ligand was improved using the Gaussian09 tool. The DFT/B3LYP method was used to calculate the energy gaps and other crucial theoretical features. The prepared hydrazine ligand complexes Co (II), Ni (II), Fe (III), Cu (II), Cd (II), Zn (II) and Mn (II) complexes were evaluated for its antimicrobial properties. As antimicrobial agents, it was found that the organic ligand was less biologically active than the targeted complexes. Gram positive bacteria (3ty7-Staphylococcus), Gram negative bacteria (3t88-Escherichia coli), and fungi (5k04-Candida albicans) all have crystal structures that interact well with the chemicals in the title, according to molecular docking.

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Synthesis, spectral, antioxidant, in vitro cytotoxicity activity and thermal analysis of Schiff base metal complexes with 2,2′-Bipyridine-4,4′-dicarboxylic acid as co-ligand

Cited by 25 publications

References 50 publications

Microwave-assisted synthesis, characterization, and in vitro biological evaluation of a novel nanocomposite using molybdenum and [2,2′-bipyridine]-4,4′-dicarboxylic acid

Microwave-assisted synthesis, characterization, and in vitro biological evaluation of a novel nanocomposite using molybdenum and [2,2′-bipyridine]-4,4′-dicarboxylic acid

Comparing Singlet Oxygen Generation of Schiff Base Substituted Novel Silicon Phthalocyanines by Sonophotochemical and Photochemical Applications

N′-((E)-3,3-Diphenyl-2,3-Dihydro-1H-Inden-1-Ylidene)-2-((Z)-2-Oxoindolin-3-Ylidene)Hydrazine-1-Carbothiohydrazide Ligand and Its Complexes: Spectroscopic, Molecular Orbital, Molecular Docking, Structural Study and Antimicrobial Activity

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