Synthesis, spectral aspects and biological activities of 5-hydroxy-2-nitrobenzaldehydethiosemicarbazone and their Mn(II), Co(II) and Ni(II) complexes

Abstract

The ligation behavior of 5-hydroxy-2-nitrobenzaldehydethiosemicarbazone (L) and its Mn(II), Co(II) and Ni(II) complexes has been synthesized and characterized by Elemental analysis, Electronic, FT-IR, Raman, EPR spectral techniques and Cyclic voltammetric study. The ligand (L) belongs to triclinic system with P1 space group. The IR spectral data of ligand indicate the taking part of sulphur and azomethine nitrogen in coordination to the central metal ion. The electronic, FT-IR and EPR spectral studies reveals all the complexes are distorted octahedral geometry. The synthesized ligand and its metal(II) complexes were tested for their antioxidant activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and antibacterial activity against E.coli, Staphylococcus aureus, Bacillus subtilis, Salmonella typhi and Klebsiella pneumonia. The antibacterial and antioxidant activities of the ligand and its metal complexes had shown moderate to good activity, among all the compounds Ni(II) complex had shown more activity.

Synthesis, characterization, and biological activity of Cu(II), Ni(II), and Zn(II) complexes of a tridentate heterocyclic Schiff base ligand derived from thiosemicarbazide and 2-benzoylpyridine

“…The nitrogen atom of the pyridine ring is also involved in coordination around the metal(II) ion. These vibration modes suggest the involvement of the sulfur atom in coordination, thus confirming the tridentate nature of the 2-(phenyl(pyridin-2-yl)methylene)hydrazine-1-carbothioamide ligand in the complexes [29,33]. This is further supported by the appearance of new bands at 484-580 and 410-415 cm -1 in the far-infrared region, assigned to ν(M-N), and ν(M-S), respecttively [15].…”

“…On the spectrum of the ligand, the strong and broad band in the 3403-3223 cm −1 range is attributed to ν(N-H) of the NH2 group and the band at 3127 cm −1 is attributed to 𝜈𝜈(N-H) of the carbazid group (N-NH-N) [28]. The strong bands at 1592 and 1061 cm −1 in the spectrum of the ligand correspond to the presence of 𝜈𝜈(C=N) of azomethine group [29] and (N-N) of the azide group. The strong band at 810 cm −1 is assigned to 𝜈𝜈(C=S) in the thiosemicarbazone [30].…”

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

“…They are extensively used due to their promising applications in biomimetic catalytic reactions, analytical chemistry [10–12], polymer coating pigments, industrial fluorescent materials, Portland cement, amphibolites, and granites [13]. They bear remarkable antifungal, antibacterial, anticancer, antiviral, and herbicidal applications [14–18] and anti-inflammatory properties, exhibited by these compounds, which can be attributed to their metal complexing abilities [19–21]. Based on their applicability in various fields, we are extending this field by the synthesis of novel mono- and binuclear hydrazone complexes.…”

Synthesis and characterization of substituted acetophenone-4, 4-dimethyl-3-thiosemicarbazone derivatives with an evaluation of antimicrobial and antioxidant activities

“…Thiosemicarbazones is a thiourea derivative, and the general formula is R 1 R 2 C=N-NH-CS-NR'R". R 1 , R 2 , R' and R" may be alkyl/aryl/hydragen or heterocyclic part (Reddy et al, 2016). Thiosemicarbazones are generally prepared from condensation of carbonyl compounds and thiosemicarbazide with alcohol and dehydrating agents.…”