Synthesis, spectral characterization, <i>in vitro</i> microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases

Bagihalli, Gangadhar B.; Patil, Sangamesh A.; Badami, Prema S.

doi:10.1080/14756360802361571

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…This versatile coordination chemistry of nickel has an area of considerable importance in inorganic chemistry with implications in other areas of chemistry and biology [8][9][10]. Schiff base complexes present suitable biometric properties that can mimic the structural features of the active sites, and they have been extensively used in various fields such as disease treatment, biochemical reaction and biological regulator [11][12][13][14]. Some articles about the interaction of DNA with macrocyclic Schiff base nickel(II) complex have been reported [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Nickel(II) complexes having different configurations controlled by N,N,O-donor Schiff-base ligands in presence of isothiocyanate as co-ligand: Synthesis, structures, comparative biological activity and DFT study

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Nickel(II) complexes having different configurations controlled by N,N,O-donor Schiff-base ligands in presence of isothiocyanate as co-ligand: Synthesis, structures, comparative biological activity and DFT study

et al. 2015

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“…The antifungal activity of synthesized Schiff bases and some of their complexes was close to that of the standard drug fluconazole (Table 4). It has been reported in the past that metal complexes with Schiff bases of formyl coumarin derivatives possess high antimicrobial activity 17,18,23,[42][43][44] . The minimum inhibitory concentration (MIC) of some selected compounds, which showed significant activity against selected bacterial and fungi species, was also determined, and results are presented in Table 5.…”

Section: In Vitro Antibacterial and Antifungal Activitymentioning

confidence: 99%

DNA cleavage and in vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with ONNO donor Schiff bases: Synthesis, spectral characterization, and electrochemical studies

Kulkarni

Patil

Badami³

2009

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of Co(II), Ni(II), and Cu(II) complexes of the type ML.2H 2 O have been synthesized with Schiff bases derived from 8-formyl-7-hydroxy-4-methylcoumarin and o-phenylenediamine/ethylenediamine. The structure of the complexes has been proposed in the light of analytical, spectral (IR, UV-Vis, ESR, and FAB-mass), magnetic, thermal, and fluorescence studies. The complexes are soluble in DMF and DMSO. The measured molar conductance values indicate that the complexes are non-electrolytes in nature. In view of IR, UV-Vis, and magnetic studies, it has been concluded that all the complexes possess octahedral geometry, in which ligand is coordinated to metal ion through the azomethine nitrogen and phenolic oxygen via deprotonation. Thermal studies provide useful information about the coordination of water molecules to the metal ion and the stability of the complexes. The redox behavior of the complexes has been investigated by an electrochemical method using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by the minimum inhibitory concentration method. DNA binding with Co(II) and Cu(II) complexes has been studied by the agarose gel electrophoresis method.

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“…All synthesized compounds are soluble in dimethylformamide and dimethylsulfoxide. All ligands and their complexes were also tested for their antibacterial (Escherichia coli, Staphylococcus aureus, Staphylococcus pyogenes and Pseudomonas aeruginosa)[25] and antifungal properties [25]…”

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confidence: 99%

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

SAMELİUK¹,

Kaplaushenko²,

Zedan³

2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: Development of methods for the synthesis, studies of chemical, physico-chemical and biological properties of 1,2,4-triazole derivatives, in particular compounds with heterocyclic scaffolds and complex compounds as potential biologically active substances.Result and Discussion: In this review, 40 scientific papers reporting the properties of 1,2,4-triazole derivatives were evaluated. Each class of compounds described in the review was reported with the prospect of forming the direction for further research.Because of there is no enough studies about biological action of 1,2,4-triazole derivatives in human, it encourages further research.

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Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases

Cited by 8 publications

References 31 publications

Nickel(II) complexes having different configurations controlled by N,N,O-donor Schiff-base ligands in presence of isothiocyanate as co-ligand: Synthesis, structures, comparative biological activity and DFT study

Nickel(II) complexes having different configurations controlled by N,N,O-donor Schiff-base ligands in presence of isothiocyanate as co-ligand: Synthesis, structures, comparative biological activity and DFT study

DNA cleavage and in vitro antimicrobial studies of Co(II), Ni(II), and Cu(II) complexes with ONNO donor Schiff bases: Synthesis, spectral characterization, and electrochemical studies

1,2,4-Triazole Derivatives in Medicine and Pharmacy and Application Prospects

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