Synthesis, Spectral, Morphology, Thermal Degradation Kinetics and Antibacterial Studies of Terpolymer Metal Complexes

Azarudeen, Raja S.; Burkanudeen, Abdul R.

doi:10.1007/s10904-011-9631-2

Cited by 19 publications

(10 citation statements)

References 34 publications

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“…The g values can also be used to calculate the magnetic field ( G ) value from the following equation: From the above equation, if G is less than 4.0, the ligand is regarded as a strong field ligand. The G value for AAPF Cu is 1.177 which clearly establishes that the AAPF Cu complex forms with a strong field ligand …”

Section: Resultsmentioning

confidence: 73%

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Studies of new oligomer–metal complexes and their antibacterial activities

Azarudeen¹,

Burkanudeen²

2012

Polymer International

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A new oligomeric ligand was synthesized from anthranilic acid and 2‐aminopyridine with formaldehyde using a condensation technique in the presence of acid medium. Oligomer–metal complexes were prepared involving transition metal ions Cu(II), Mn(II) and Zn(II) using the synthesized oligomer as ligand. The oligomeric ligand and its metal complexes were characterized using various spectral techniques such as Fourier transform infrared, electronic, electron spin resonance, 1H NMR and 13C NMR. Gel permeation chromatography was used to determine number‐, weight‐ and size‐average molecular weights of the oligomeric ligand. The surface characteristics and nature of the oligomeric ligand and its metal complexes were examined using scanning electron microscopy and X‐ray diffraction analysis. The thermal properties and degradation behaviour of the oligomeric ligand and its complexes were investigated using thermogravimetric analysis. Kinetic and thermodynamic studies of the ligand and its metal complexes were carried out using Freeman–Carroll (FC) and Sharp–Wentworth (SW) methods. From the thermogravimetric data, kinetic and thermodynamic parameters such as activation energy, order of reaction, entropy change, apparent entropy, frequency factor and free energy change were calculated. The activation energy was further calculated from the Phadnis‐Deshpande (PD) method and the degradation mechanism for the thermal decomposition reaction is proposed. The activation energy calculated from the FC and SW methods was in good agreement with that calculated from the PD method. The oligomeric ligand and its metal complexes were screened for antibacterial activity. It was found that the synthesized compounds were potent antibacterial agents. © 2012 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 73%

“…Kinetic and thermodynamic parameters were calculated and the thermal degradation mechanism was also proposed. The antibacterial activity was tested against certain pathogenic bacteria and the results proved that the ligand and its metal complexes had good activity against the growth of those bacterial strains …”

Section: Introductionmentioning

confidence: 99%

Studies of new oligomer–metal complexes and their antibacterial activities

Azarudeen¹,

Burkanudeen²

2012

Polymer International

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“…The developed chitosan‐copolymer blend membranes were screened for antibacterial activity by disc diffusion technique according to earlier literature . The bacterial strains used for the analysis are Escherichia coli, Staphylococcus aureus (ATCC 25923) and Salmonella typhimurium (ATCC 23564).…”

Section: Methodsmentioning

confidence: 99%

Antibacterial chitosan-copolymer membranes for drug delivery: synthesis, characterization, drug release profile and kinetics

Azarudeen¹,

Thirumarimurugan²,

Athmiya³

et al. 2017

J. Chem. Technol. Biotechnol

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BACKGROUND New copolymeric membranes were offered for the efficient delivery of antibiotic drug using newly developed chitosan–copoly(semicarbazide–formaldehyde–phenylhydrazine) blend membranes. The membranes were characterized by elemental, spectral and scanning electron microscopy to establish the chemical structure and morphology. Swelling behavior, drug loading capacity and drug release studies was extensively studied. Furthermore, the membranes were assayed for antibacterial activity against selected bacterial strains viz. Escherichia coli, Staphylococcus aureus and Salmonella typhimurium. RESULTS The chitosan membrane had excellent loading efficiency with 85.55% whereas, if the composition of chitosan is reduced to half, the loading efficiency becomes 36.37%. The chitosan membrane released 79.31% of drug within 2.5 h, where as low chitosan content membranes have released the drug to about 24.82 and 30.34%, respectively. However, the average chitosan content membrane had shown a slow and steady drug release at 50.34 and 62.75%. CONCLUSION The composition of chitosan content also governs the swelling behavior i.e. the increased chitosan content showed excellent swelling behavior leads to profound drug delivery. The results indicate that the chitosan blend membranes have effectively released the antibiotic drug in a short time and proved to be a promising candidate for the drug delivery. The kinetic study establishes that the drug release is well fit with the Higuchi model and follows swelling and diffusion‐controlled mechanisms. © 2016 Society of Chemical Industry

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“…The thermal stability of the synthesized compounds was determined and the results proved that all the compounds were thermally highly stable. The compounds were also screened for antibacterial activity and the results confirmed that all the metal complexes were more potent antibacterial agents than their respective ligands, which is quite naturally due to the incorporation of metal ions into the polymeric backbone …”

Section: Introductionmentioning

confidence: 91%

Polymer‐supported metal complexes as antibacterial agents: synthesis, characterization and thermal degradation kinetics

Azarudeen¹,

Ahamed²,

Prabu

et al. 2014

Applied Organom Chemis

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Polymeric metal complexes were prepared using a synthesized novel terpolymer ligand involving anthranilic acid–o‐toluidine–formaldehyde by a polycondensation technique. The synthesized ligand and its metal complexes were characterized using elemental analysis and molar conductivity measurements, and FT‐IR, electronic, electron spin resonance and NMR (1H and 13C) spectral methods. The surface morphology and the nature of the synthesized compounds were examined using scanning electron microscopy and X‐ray diffraction. The thermal stabilities of the ligand and its metal complexes were determined using thermogravimetric analysis (TGA). From the TGA results, various kinetic parameters, i.e. activation energy and order of reaction, and thermodynamic parameters, i.e. entropy change, apparent entropy, frequency factor and free energy change, were determined using the Freeman–Carroll and Sharp–Wentworth methods. In addition, a thermal degradation model was also proposed using the Phadnis–Deshpande method. The thermal stability of the ligand and its metal complexes was found to be appreciably high; in particular, the ligand showed very high stability compared to its metal complexes due to intramolecular hydrogen bonding. Furthermore, the synthesized compounds were subjected to in vitro antibacterial studies with various microorganisms. The results of the studies confirmed that the compounds showed better antibacterial results than a standard antibacterial drug. Copyright © 2014 John Wiley & Sons, Ltd.

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Synthesis, Spectral, Morphology, Thermal Degradation Kinetics and Antibacterial Studies of Terpolymer Metal Complexes

Cited by 19 publications

References 34 publications

Studies of new oligomer–metal complexes and their antibacterial activities

Studies of new oligomer–metal complexes and their antibacterial activities

Antibacterial chitosan-copolymer membranes for drug delivery: synthesis, characterization, drug release profile and kinetics

Polymer‐supported metal complexes as antibacterial agents: synthesis, characterization and thermal degradation kinetics

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