Synthesis, spectral properties and thermal behaviour of zinc(II) acetylsalicylate

Lambi, John Ngolui; Nsehyuka, Alfred T.; Egbewatt, Nkongho; Cafferata, Lázaro F. R.; Arvía, Alejandro Jorge

doi:10.1016/s0040-6031(02)00354-4

Cited by 17 publications

(8 citation statements)

References 15 publications

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“…The absence of free carbonyl [ ν (C O)] vibration around 1700 cm −1 is an indication that the entire carboxylate group is engaged in the coordination bond. Lambi et al 37 and Mesubi et al 38 have shown that when the value of the separation between the bands, Δ ν (= ν COO asym − ν COO sym ) is above 200 cm −1 , a monodentate mode of bonding between the carboxylate group (COO − ) of the ligand and the metal atoms is indicated, a value of Δ ν below 110 cm −1 is attributable to the chelating bidentate mode while Δ ν between 140 cm −1 and 200 cm −1 is attributed to the bridged bidentate bonding mode. 39 All the samples investigated (S1 to S5) showed Δ ν values of 150 cm −1 corresponding to the bridged bidentate bonding mode of the octanoic acid to the metals These FTIR results are in good agreement with those reported on iron carboxylate complexes.…”

Section: Resultsmentioning

confidence: 99%

Structural characterization and magnetic properties of undoped and copper-doped cobalt ferrite nanoparticles prepared by the octanoate coprecipitation route at very low dopant concentrations

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Structural characterization and magnetic properties of undoped and copper-doped cobalt ferrite nanoparticles prepared by the octanoate coprecipitation route at very low dopant concentrations

et al. 2018

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“…AZN was prepared as described in the literature, and the structure was confirmed by IR, 1 H NMR, UV and elemental analysis. AZN was shown to possess a ligand‐to‐metal ratio of 2 : 1 with two molecules of water acting as water of crystallization.…”

Section: Methodsmentioning

confidence: 99%

Comparison and analysis on the serum‐binding characteristics of aspirin–zinc complex and aspirin

Zhang

Wang

et al. 2017

Luminescence

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This study was designed to compare the protein-binding characteristics of aspirin-zinc complex (AZN) with those of aspirin itself. AZN was synthesized and interacted with a model transport protein, human serum albumin (HSA). Three-dimensional fluorescence, ultraviolet-visible and circular dichroism (CD) spectra were used to characterize the interaction of AZN with HSA under physiological conditions. The interaction mechanism was explored using a fluorescence quenching method and thermodynamic calculation. The binding site and binding locality of AZN on HSA were demonstrated using a fluorescence probe technique and Förster non-radiation energy transfer theory. Synchronous fluorescence and CD spectra were employed to reveal the effect of AZN on the native conformation of the protein. The HSA-binding results for AZN were compared with those for aspirin under consistent experimental conditions, and indicated that aspirin acts as a guide in AZN when binding to Sudlow's site I, in subdomain IIA of the HSA molecule. Moreover, compared with aspirin, AZN showed greater observed binding constants with, but smaller changes in the α-helicity of, HSA, which proved that AZN might be easier to transport and have less toxicity in vivo.

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“…The complex was identified as bis(acetylsalicylato)-diaquozinc(II)-complex [Zn(acetylsalicylate) 2 (H 2 O) 2 ] based on the preliminary examinations by IR, NMR, and DSC and comparing the results obtained with that reported. 14,31,32 The IR study (Table 4) showed hat the spectrum of zinc acetylsalicyclic acid complex does not exhibit the band representing CO in the COOH group at around 1690 cm -1 . The absorption of the carboxyl group is shifted in the direction to longer wave length indicating that it is strongly involved in complexation with zinc.…”

Section: Characterization Of Zinc-aspirin Complexmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics Evaluation of Prepared Zinc Aspirin Suppositories

Mohamed

Aly

Abdel‐Rahman

2003

Bulletin of Pharmaceutical Sciences. Assiut

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bioavailabilities were 94, 88.89 and 83.63 for zinc aspirin; aspirin lysinate and aspirin respectively. The peak plasma concentration (C max ) were 54. 5188, 50.271.68 and 48.091.15 ugl -1 for zinc aspirin, aspirin lysinate and aspirin, respectively. There was significant difference in the t max . The area under the plasma concentration-time curve (AUC) values were 148. 932.79, 140.832.3 and 132.493.56 ug.h/ml for zinc aspirin, aspirin lysinate and aspirin, respectively. There were significant differences in the C max , t max and AUC following oral administration. The anti-inflammatory and analgesic studies revealed that zinc aspirin administered rectally or orally was more effective as anti-inflammatory and analgesic. The invivo studies were correlated with the in-vitro release studies of aspirin from the prepared suppositories.Based on the obtained results, the authors recommend the possible use of zinc aspirin as a substitute of aspirin containing products.

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Synthesis, spectral properties and thermal behaviour of zinc(II) acetylsalicylate

Cited by 17 publications

References 15 publications

Structural characterization and magnetic properties of undoped and copper-doped cobalt ferrite nanoparticles prepared by the octanoate coprecipitation route at very low dopant concentrations

Structural characterization and magnetic properties of undoped and copper-doped cobalt ferrite nanoparticles prepared by the octanoate coprecipitation route at very low dopant concentrations

Comparison and analysis on the serum‐binding characteristics of aspirin–zinc complex and aspirin

Pharmacokinetics and Pharmacodynamics Evaluation of Prepared Zinc Aspirin Suppositories

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