Synthesis, spectroscopic characterization, catalytic and antibacterial studies of ruthenium(III) Schiff base complexes

Shoair, A.F.; El-Shobaky, A.R.; Abo-Yassin, H.R.

doi:10.1016/j.molliq.2015.07.001

Cited by 13 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The screening tests have thus shown that metal carbonyl complex possesses the highest activity index as compared to other molecular species under the present investigation. The remarked activity against gram negative species culminates the relevance of polyoxy millieu with the cell wall structure [43,44]. The respective activity index can be calculated by the following relation: From A.I.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Mir¹,

Jain²,

Maurya³

2021

J Trans Met Compl

View full text Add to dashboard Cite

Nosocomial infections are ranked as the second-largest infections. E. coli is the primary causative agent of this dreadful infection. To develop effective antibiotic substances against hospitalacquired infections, herein a novel carbon monoxide tagged Ru(II) complex of N-o-hydroxyacetophenone-ethylenediamine-N -o-vanillin is reported as an effective antimicrobial agent of its form. In addition to molecular structure elucidation, an explanation has been made about the related charge topography concerning the biological effect. The formulation of the complex based on hyphenated experimentaltheoretical evaluation suggests an octahedral structure. Density functional study was carried out confined to the formalism as B3LYP functional/LanL2DZ basis set for Ru atom and 6-31 g(d,p) for the rest of the atoms. The stable form of geometry and other electron density plots are the prominent inclusions discussed in this work. The primary characterization techniques that have been used for the formulation include elemental analysis, mass spectrometry, nuclear magnetic resonance (C and H), UV-Vis, and FT-IR. The experimentally observed data was validated with theoretical/computational outputs. Both the experimental and theoretical results sound in excellent agreement when compared at each step of the characterization. A suitable trans-octahedral geometry has been suggested for the complex. From the antimicrobial actions against nosocomial E. coli, an MIC value of 30 μM was obtained for the selected compound and hence can be assumed as a standard novel antibiotic substance against nosocomial infections. The respective microbial study has been discussed, keeping in view the microbial growth study, the qualitative and quantitative analysis to add fascination to the work being reported.

show abstract

Section: Antibacterial Activitymentioning

confidence: 99%

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Mir¹,

Jain²,

Maurya³

2021

J Trans Met Compl

View full text Add to dashboard Cite

show abstract

“…The molar conductivities were measured for the complexes (10 À3 M) in methanol 121 Ω À1 cm 2 mol À1 (1), 120 Ω À1 cm 2 mol À1 (2), 121 Ω À1 cm 2 mol À1 (3), and 128 Ω À1 cm 2 mol À1 (4), and these values are in good agreement with 1:1 electrolytic behavior of the ruthenium complexes. [34][35][36]…”

Section: Molar Conductancementioning

confidence: 99%

Enhanced anticancer property of bio‐organometallic nano composites: Design, characterization, and biological evaluation

Sindhu

Kalaivani

Prabhakaran

2021

Applied Organom Chemis

View full text Add to dashboard Cite

Series of organoruthenium complexes and their nano biocomposites were prepared and analyzed by various spectral analyzed techniques like infrared (IR), UV-Vis, 1 H-nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) spectroscopy, and high-resolution mass spectrometry (HR-MS). The redox properties of organoruthenium complexes were studied by cyclic voltammogram. UV-Vis and fluorescence spectroscopy employed to study the binding affinity of Ru (III) complexes with CT-DNA and serum albumin (bovine serum albumin [BSA]). From the K sv and K b values, the interaction between BSA and organoruthenium complexes confirmed the mechanism of binding as static quenching. Scanning electron microscopic (SEM) studies validated the formation of new hybrid organometallic proteomics (P1-P4), while binding of the complexes with protein (BSA). A comparative cytotoxic profile of organoruthenium complexes and their nano biocomposites were evaluated. The results revealed the higher anticancer activity of nano biocomposites than their parent organoruthenium derivatives.

show abstract

New organoruthenium metallates containing ferrocenecarboxalidine thiosemicarbazones and their nucleic acid/albumin binding and in vitro cytotoxicity

Sindhu

Kalaivani

Prabhakaran

2020

Applied Organom Chemis

View full text Add to dashboard Cite

A string of four new hetero binuclear Ru(III) complexes of ferrocenecarboxaldehyde-4(N)-substituted thiosemicarbazones were synthesized and characterized by various spectral (infrared, ultraviolet-visible, Electron Paramagnetic Resonance (EPR) and High Resolution Mass Spectrometry (HR-MS) techniques. The binding abilities of the ligands/complexes with nucleic acid (calf thymus DNA, CT-DNA) and bovine serum albumin (BSA) were analyzed by absorption and emission titration methods. The complexes exhibited better DNA binding affinity than their parent ligands. The interaction with CT-DNA was found to be intercalative and with BSA static quenching mechanism was observed. All the synthesized Ru(III) complexes were subjected to study their in vitro cytotoxicity against MCF-7 (human breast cancer) and HT-29 (human colon cancer) cell lines. Among the four complexes, complex 3 [RuCp (FF-etsc)PPh 3 ]Cl exhibited the highest cytotoxicity in MCF-7 cells and complex 4 [RuCp (FF-ptsc)PPh 3 ]Cl was the most active on HT-29 cells. K E Y W O R D S acridine orange-ethidium bromide (AO-EB)/4, 6-diamidino-2-phenylindole (DAPI) staining, morphological studies, MTT assay, Ru(III) complexes

show abstract

Synthesis, spectroscopic characterization, catalytic and antibacterial studies of ruthenium(III) Schiff base complexes

Cited by 13 publications

References 38 publications

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Formulation, Molecular Charge Topography, and Nosocomial Anti-Infectious Potential of Ruthenium Carbonyl Complex of N-o-Hydroxyacetophenone-Ethylenediamine-N′-o-Vanillin

Enhanced anticancer property of bio‐organometallic nano composites: Design, characterization, and biological evaluation

New organoruthenium metallates containing ferrocenecarboxalidine thiosemicarbazones and their nucleic acid/albumin binding and in vitro cytotoxicity

Contact Info

Product

Resources

About