Synthesis, Spectroscopic Studies and Antimicrobial Activity of Novel Aromatic Hydrazones Derived from 1-Hydralazinophthalazine

Yong, Joseph N.; Asobo, P. Forche; Nyongbela, Kennedy D.; Njong, Romanus N.; Nfor, Oswald Ndi

doi:10.9734/acsj/2016/26059

Cited by 5 publications

(2 citation statements)

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“…In view of the above and in continuation of our previous studies on the synthesis and application of hydalazine hydrochloride based ligands [18] [19] [20] here in we report on detailed investigation on the inhibition behavior of hydralazine hydrochloride (HPZ) and its three derivatives…”

Section: Introductionmentioning

confidence: 91%

Corrosion Inhibitory Studies of Novel Schiff Bases Derived from Hydralazine Hydrochloride on Mild Steel in Acidic Media

Njong¹,

Ndosiri²,

Nfor³

et al. 2018

OJPC

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The inhibition performance of 1-hydralazinophthalazine (HPZ) (1), and syn-thesized1-(2-[(5-methylfuran-2-yl)methylene)] hydrazono) phthalazine (MFHPZ) (2), 1-(phthalazin-1(2H)-one) [(pyridin-2-yl) ethylidene] hydrazone (ACPHPZ) (3) and (2-acetylthiophene hydrazono) phthalazine (ACTHPZ) (4) has been investigated for mild steel in 1 M HCl. Compound 4 shows maximum inhibition efficiency of 93% at 5.0 × 10 −3 M concentration. The evaluation of thermodynamics and activation parameters indicated spontaneous adsorption of the inhibitor molecules which takes place through chemisorption. The adsorption of 3 and 2 follows Langmuir adsorption isotherm and Temkin adsorption isotherm for 4 and 1. The inhibitor efficiency was of the order 4 > 3 > 1 > 2. Impedance study for the representative inhibitor compounds 4 and 3 showed that decrease in charge transfer resistance is responsible for effective protection of mild steel surface by the tested inhibitor.

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Section: Introductionmentioning

confidence: 91%

Corrosion Inhibitory Studies of Novel Schiff Bases Derived from Hydralazine Hydrochloride on Mild Steel in Acidic Media

Njong¹,

Ndosiri²,

Nfor³

et al. 2018

OJPC

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“…Such biological activities include anti-leprosy, antimicrobials, antituberculosis, anti-tumor, and antihypertensive agents. These varied biological activities have drawn the attention of many researchers to the study of hydrazones [8].…”

Section: Introductionmentioning

confidence: 99%

Computational Studies of Some Hydrazone Derivatives as Antibacterial Agent: DFT and Docking Methods

Oyebamiji

Adeleke

Ajibade

et al. 2019

J. Pure App. Chem. Res.

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Quantum chemical calculations through density functional theory and docking study were carried out on a set of seven hydrazones and S. aureus cell line (4b19) so as to observe their inhibitory abilities of hydrazones. Many parameters which describe the anti-S. aureus were evaluated. All the compounds under study were docked against S. aureus cell line as receptors and the resulting binding energies reflected the extent of their binding affinities. 2,4-dinitrophenylhydrazone of formaldehyde showed the highest binding affinity.

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Pyridazines and Their Benzo Derivatives

Chinigo

Feng

Hoy

et al. 2022

Comprehensive Heterocyclic Chemistry IV

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Synthesis, Spectroscopic Studies and Antimicrobial Activity of Novel Aromatic Hydrazones Derived from 1-Hydralazinophthalazine

Cited by 5 publications

References 0 publications

Corrosion Inhibitory Studies of Novel Schiff Bases Derived from Hydralazine Hydrochloride on Mild Steel in Acidic Media

Corrosion Inhibitory Studies of Novel Schiff Bases Derived from Hydralazine Hydrochloride on Mild Steel in Acidic Media

Computational Studies of Some Hydrazone Derivatives as Antibacterial Agent: DFT and Docking Methods

Pyridazines and Their Benzo Derivatives

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