Synthesis, spectroscopic studies of new water-soluble Co(II) and Cu(II) macrocyclic complexes of 4,15-bis(2-hydroxyethyl)-2,4,6,13,15,17-hexaazatricyclodocosane: their interaction studies with calf thymus DNA and guanosine 5′ monophosphate

Arjmand, Farukh; Aziz, Mubashira; Chauhan, Mala

doi:10.1007/s10847-008-9417-5

Cited by 45 publications

(12 citation statements)

References 78 publications

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“…Moreover, the solutions of these complexes did not precipitate during this time period. These results were indicative of the robust nature of the complexes [39][40][41]. Therefore, the complexes under study did not undergo hydrolysis and consequent dissociation of chlorido ligands.…”

Section: Solution Stabilitymentioning

confidence: 73%

Design and synthesis of thalidomide based dithiocarbamate Cu(II), Ni(II) and Ru(III) complexes as anticancer agents

Ali¹,

Wani²,

Saleem³

et al. 2013

Polyhedron

120

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Section: Solution Stabilitymentioning

confidence: 73%

Design and synthesis of thalidomide based dithiocarbamate Cu(II), Ni(II) and Ru(III) complexes as anticancer agents

Ali¹,

Wani²,

Saleem³

et al. 2013

Polyhedron

120

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“…Additionally, hypochromaticities were recorded for all the compounds with the addition of DNA in different concentrations (1.45 × 10 –4 to 1.0 × 10 –5 M). Such changes are obvious evidence of the formation of DNA adducts . It is believed that these hypochromic shifts are probably due to the covalent and noncovalent bonds, which were observed in all target compounds …”

Section: Resultsmentioning

confidence: 96%

“…Such changes are obvious evidence of the formation of DNA adducts. 37 It is believed that these hypochromic shifts are probably due to the covalent and noncovalent bonds, which were observed in all target compounds. 38 Furthermore, the values of DNA binding constants for all ILs range from 4.543 × 10 4 to 3.518 × 10 5 , signifying a good interaction with DNA.…”

Section: Resultsmentioning

confidence: 96%

Synthesis, Characterization, DNA Binding, Anticancer, and Molecular Docking Studies of Novel Imidazolium-Based Ionic Liquids with Fluorinated Phenylacetamide Tethers

et al. 2020

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Newer imidazolium ionic liquid (IL) halides 4a−f appending variety of fluorinated phenylacetamide side chains were designed and synthesized through quaternization of 1-methyl and/ or 1,2-dimethylimidazole with appropriate 2-chloro-N-(fluorinatedphenyl)acetamides. The resulting ILs were converted to their respective ionic liquid analogues carrying fluorinated counteranions (PF 6 − , BF 4 − , and/or CF 3 COO − ) 5a−r. All newly synthesized ILs were fully characterized using several spectroscopic experiments such as 1 H, 13 C, 11 B, 19 F, 31 P NMR, and mass analysis. The synthesized ionic liquids were investigated for their DNA binding and anticancer activities. The obtained DNA binding constants ranged from 1.444 × 10 5 to 3.518 × 10 5 , indicating a reasonably good binding affinity. The percentage of anticancer activities ranged from 48 to 59 with H-1229 cell line, showing quite good anticancer potential. The modeling studies indicated the interactions of the reported molecules with DNA via hydrogen bonds. These were in agreement with those of DNA binding and anticancer results. Briefly, the designed ionic liquids may be used as good anticancer candidates for treating human cancer.

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“…All these results indicated the robust nature of the complexes. [63][64][65] Therefore, the complexes under study did not undergo hydrolysis.…”

Section: Resultsmentioning

confidence: 99%

Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies

et al. 2014

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show abstract

Synthesis, spectroscopic studies of new water-soluble Co(II) and Cu(II) macrocyclic complexes of 4,15-bis(2-hydroxyethyl)-2,4,6,13,15,17-hexaazatricyclodocosane: their interaction studies with calf thymus DNA and guanosine 5′ monophosphate

Cited by 45 publications

References 78 publications

Design and synthesis of thalidomide based dithiocarbamate Cu(II), Ni(II) and Ru(III) complexes as anticancer agents

Design and synthesis of thalidomide based dithiocarbamate Cu(II), Ni(II) and Ru(III) complexes as anticancer agents

Synthesis, Characterization, DNA Binding, Anticancer, and Molecular Docking Studies of Novel Imidazolium-Based Ionic Liquids with Fluorinated Phenylacetamide Tethers

Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies

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