Synthesis, stability and anti-fatigue activity of selenium nanoparticles stabilized by Lycium barbarum polysaccharides

Liu, Guoyan; Yang, Xue; Zhang, Jixian; Liang, Li; Miao, Feng; Ji, Tao; Ye, Zhiqiang; Chu, Meng; Ren, Jiaoyan; Xu, Xin

doi:10.1016/j.ijbiomac.2021.03.018

Cited by 70 publications

(31 citation statements)

References 63 publications

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“…Physical fatigue is usually shown in a deterioration in exercise performance and even difficulty in sustaining regular physical activities [ 2 ]. There are many reasons underlying exercise-induced fatigue: first, the consumption of energy sources and the over-production and accumulation of metabolic products [ 3 , 4 ]; second, the excessive generation of reactive oxygen species (ROS) and the disorder of immune system [ 5 ]; last, the blood-oxygen concentration balance as well as muscle and liver glycogen homeostasis are difficult to maintain [ 6 ]. Excessive fatigue and lack of reasonable adjustment have been a threat to human health for many years [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Shi

Zhang

Wang

et al. 2022

Foods

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The potential of soft-shelled turtle peptides (STP) against fatigue was evaluated. Mice orally supplemented with STP significantly increased the swimming time until tiredness by 35.4–57.1%. Although not statistically significant, STP increased muscle and thymus mass. In addition, the serum lactate, ammonia, blood urea nitrogen content and creatine kinase activity in STP-fed mice were dramatically decreased when compared to the control group. Furthermore, STP supplementation increased the reserves of liver glycogen and muscle glycogen, thus improved the energy metabolism system of mice. STP treatment contributed to increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as a decrease in malondialdehyde (MDA), indicating an improvement in oxidative stress protection. The Western blot (WB) results indicated that the STP supplement effectively altered the expression of oxidative stress-related protein by modulating the NRF2/KEAP1 pathway. In summary, STP affected NRF2/KEAP1 levels in skeletal muscle, leading to antioxidant activity and a slower time to exhaustion during exercise.

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Section: Introductionmentioning

confidence: 99%

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Shi

Zhang

Wang

et al. 2022

Foods

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“…As an essential micronutrient for human health, selenium (Se) plays a vital role in protecting against oxidative stress [ 5 ]. Nevertheless, the beneficial and harmful doses of Se is an extremely narrow margin, which limits its practical applications in food and medicine [ 6 ]. Therefore, it is necessary to take effective measures to solve this problem.…”

Section: Introductionmentioning

confidence: 99%

“…Natural bioactive polysaccharides have attracted more and more attention because they are rich in hydrophilic groups, such as hydroxyls, and are considered as ideal templates for SeNPs stabilization. A variety of polysaccharides have been reported to modify SeNPs and the modified SeNPs have been found to have strong antioxidant activity [ 6 , 11 , 12 ]. Chondroitin sulfate (CS), a natural anionic glycoaminoglycan, is extracted from various marine animal cartilages, such as shark, skate and so on [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nano-Selenium Decorated by Chondroitin Sulfate Derived from Shark Cartilage and Investigation on Its Antioxidant Activity

Chen

et al. 2022

Marine Drugs

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In the present study, a selenium-chondroitin sulfate (SeCS) was synthesized by the sodium selenite (Na2SeO3) and ascorbic acid (Vc) redox reaction using chondroitin sulfate derived from shark cartilage as a template, and characterized by SEM, SEM-EDS, FTIR and XRD. Meanwhile, its stability was investigated at different conditions of pH and temperatures. Besides, its antioxidant activity was further determined by the DPPH and ABTS assays. The results showed the SeCS with the smallest particle size of 131.3 ± 4.4 nm and selenium content of 33.18% was obtained under the optimal condition (CS concentration of 0.1 mg/mL, mass ratio of Na2SeO3 to Vc of 1:8, the reaction time of 3 h, and the reaction temperature of 25 °C). SEM image showed the SeCS was an individual and spherical nanostructure and its structure was evidenced by FTIR and XRD. Meanwhile, SeCS remained stable at an alkaline pH and possessed good storage stability at 4 °C for 28 days. The results on scavenging free radical levels showed that SeCS exhibited significantly higher antioxidant activity than SeNPs and CS, indicating that SeCS had a potential antioxidant effect.

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“…The molecular weight of polysaccharides was determined by gel permeation chromatography (GPC) [ 31 ]. The injection concentration of the sample is 1 mg/mL.…”

Section: Methodsmentioning

confidence: 99%

Subcritical Water Enhanced with Deep Eutectic Solvent for Extracting Polysaccharides from Lentinus edodes and Their Antioxidant Activities

Zhang

Liu

et al. 2022

Molecules

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In the present study, subcritical water extraction (SWE) assisted with deep eutectic solvent (DES) is used to extract Lentinus edodes polysaccharides (LEP). In addition, the antioxidant activity of the polysaccharide samples was also investigated. Based on a single factor test and response surface test, the optimal extraction factors were a liquid–solid solvent of 40:1 mL/g, extraction temperature of 147.23 °C, water content of 39.76% and extraction time of 17.58 min. Under these extraction conditions, the yield of LEP was 6.26 ± 0.08%. Compared with the SWE and hot water extraction (HWE), it improved by 19.24% and 17.01%, respectively. In addition, the results of monosaccharide composition, molecular weight, FT-IR, UV and SEM confirmed that the extracts had the features of polysaccharides. Interestingly, the polysaccharides obtained with the SWE assisted with the DES procedure showed a higher DPPH scavenging activity, hydroxyl radical scavenging activity and hydrogen peroxide scavenging activity, which indicated that the polysaccharides with this method had a stronger antioxidant activity. These findings demonstrated that the SWE-assisted DES is a strong method to obtain polysaccharides from Lentinus edodes for food, biopharmaceutical and other industrial production.

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Synthesis, stability and anti-fatigue activity of selenium nanoparticles stabilized by Lycium barbarum polysaccharides

Cited by 70 publications

References 63 publications

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Soft-Shelled Turtle Peptide Supplementation Modifies Energy Metabolism and Oxidative Stress, Enhances Exercise Endurance, and Decreases Physical Fatigue in Mice

Preparation and Characterization of Nano-Selenium Decorated by Chondroitin Sulfate Derived from Shark Cartilage and Investigation on Its Antioxidant Activity

Subcritical Water Enhanced with Deep Eutectic Solvent for Extracting Polysaccharides from Lentinus edodes and Their Antioxidant Activities

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