Synthesis, stereochemistry, and pharmacological activity of 1-[2-(3,4-dimethoxyphenyl) ethyl]-2-methyl-4-ketodecahydroquinoline and the corresponding acetylenic alcohols

The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines

“…13 In the second case, "primarily one isomer" of the product was obtained, the structure of which is likely to be quinolizidinone 27. 14 In both of these cases, the suggested product is the "all equatorial isomer" which may reflect thermodynamic control. Scheme 9.…”

Synthesis and Anticholinesterase Activity of N-Oxyalkyl-substituted Pyridinium and Hydroquinolinium Salts and Their Isologs

“…As is known, piperidinium cycle enters into the composition of various natural substances, many of which have proved to be valuable medicinals with a broad spectrum of pharmacological properties, including n-cholinoblocking [1], anesthetic [2], psychotropic [3,4], and anticholinesterase [5]. However, the anticholinesterase activity of N-oxyalkylpiperidines and N-oxyalkylpyridinium salts containing the acetylcholine moiety is still insufficiently studied.…”