Synthesis, structural characterisation, bio-potential efficiency and DNA cleavage applications of nicotinamide metal complexes

Dilip, C. Surendra; Kumar, Vishwa; Venison, S. John; Potheher, I. Vetha; Subahashini, D. Rajalaxmi

doi:10.1016/j.molstruc.2013.02.019

Cited by 15 publications

(2 citation statements)

References 26 publications

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“…The melting curves of CT-DNA in the absence and presence of complexes 1-3 are shown in Figure 4; As shown in Figure 4, The T m of CT-DNA in the absence of the complexes is 62.2˚C ± 0.2˚C, meanwhile, when the complexes at a concentration ratio [V]/[DNA] of 1:4, we can observe that T m values in the presence of the complexes 1, 2 and 3 are 68.3˚C ± 0.2˚C, 65.3˚C ± 0.2˚C, 69.2˚C ± 0.2˚C, respectively. A comparison of the ΔT m values of the complexes (6.1˚C, 3.1˚C and 7.0˚C for 1, 2, and 3, respectively) was agreement with those classical intercalators [47] [48], which provided strong evidence for their binding with DNA by intercalation.…”

Section: Thermal Denaturation Studiessupporting

confidence: 77%

Photocleavage Properties and DNA-Binding Studies of Oxovanadium Complexes Incorporating 2-(2-Hydroxybenzylideneamino) Isoindoline-1,3-Dione and Fluoro-Phenanthroline Derivatives

Ying¹,

Zeng²,

Lu³

et al. 2014

OJIC

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Three mononuclear oxovanadium complexes [VO(Hbid)(CF3PIP)] (1) (Hbid=(E)-2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione, CF3PIP=2-(2-trifluoromethyl phenyl)imidazole[4,5-f][1,10] phenanthroline), [VO(Hbid)(m-CF3PIP)]; (2) (m-CF3PIP=2-(3-trifluoromethyl phenyl)imidazole [4, 5-f][1,10]phenanthroline) and [VO(Hbid)(p-CF3PIP)]; (3) (p-CF3PIP=2-(4-trifluoromethyl phenyl) imidazole[4,5-f][1,10]phenanthroline) have been synthesized and characterized by elemental analysis, IR, molar conductance, ES-MS and 1 H NMR. The DNA-binding properties of these complexes were studied by using UV-Vis absorption titration, fluorescence spectra, viscosity measurements and thermal denaturation studies. The results show that 1, 2 and 3 interact with calf thymus DNA (CT-DNA) by intercalation modes and the magnitude of their intrinsic binding constants (Kb values) follows the order: 2 < 1 < 3. Furthermore, their photocleavage properties with pBR322 plasmid DNA were investigated by agarose gel electrophoresis experiments. The DNA cleavage capacity of complex 3 is also stronger than that of 1 and 2.

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Section: Thermal Denaturation Studiessupporting

confidence: 77%

Photocleavage Properties and DNA-Binding Studies of Oxovanadium Complexes Incorporating 2-(2-Hydroxybenzylideneamino) Isoindoline-1,3-Dione and Fluoro-Phenanthroline Derivatives

Ying¹,

Zeng²,

Lu³

et al. 2014

OJIC

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“…Thus, the steric effect arises on the picolinic structure which is due to the accumulation of lone pair electrons on the pyridine ring nitrogen (N) atom [16]. Hence, the neutral 2-picolinic acid molecule does not reduce or retrenchment the twisting angle between the arms of the pyridine ring.…”

Section: 1crystal Structurementioning

confidence: 99%

Growth, structure, spectral and optical properties of semiorganic crystal: Pyridine-1-ium-2-carboxylatehydrogenbromide

Gowri¹,

Devi²,

Priya³

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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New bioactive Pt(II) binary and ternary metal complexes with guaifenesin drug: Synthesis, geometrical structure, and spectroscopic and thermal characterization

Mahmoud

2016

Applied Organom Chemis

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Three new binary and ternary metal complexes of Pt(II) with guaifenesin (GFS) drug have been prepared by chelation to guaifenesin ligand (as primary ligand) and glycine amino acid (HGly) and 1,10‐phenanthroline (1,10‐Phen) (as secondary ligands). Characterization was conducted based on elemental analysis, molar conductance, infrared (IR) spectroscopy, thermogravimetric analysis and X‐ray diffraction. The complexes were found to have the formulae [Pt(GFS)2]⋅3H2O (1), [Pt(GFS)2(Gly)]Cl⋅H2O (2) and [Pt(GFS)2(Phen)]Cl2 (3). Magnetic and spectroscopic data revealed complexes 1–3 to have octahedral geometry. IR spectra suggested that GFS ligand coordinated in mononegative tridentate mode (OOO) for 1 but in neutral bidentate mode (OO) for 2 and 3. In addition, HGly behaves as mononegative bidentate coordinated to Pt(II) metal via deprotonated carboxylate O and amino group. IR data also evidenced the bidentate nature of 1,10‐Phen ligand. The molecular and electronic structure of Pt(II) complex 1 was optimized theoretically and the quantum chemical parameters were calculated. Complexes 1–3 were screened for their antibacterial activity on Gram‐positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram‐negative bacteria (Escherichia coli and Neisseria gonorrhoeae) and for their in vitro antifungal activity against Candida albicans. The three Pt(II) complexes showed remarkable biological and cytotoxic activity. The chelates were also screened for their in vitro anticancer activity against the MFC7 breast cell line. Complex 3 showed the highest activity with a low IC50 value of 3.38 μg ml−1.

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Synthesis, structural characterisation, bio-potential efficiency and DNA cleavage applications of nicotinamide metal complexes

Cited by 15 publications

References 26 publications

Photocleavage Properties and DNA-Binding Studies of Oxovanadium Complexes Incorporating 2-(2-Hydroxybenzylideneamino) Isoindoline-1,3-Dione and Fluoro-Phenanthroline Derivatives

Photocleavage Properties and DNA-Binding Studies of Oxovanadium Complexes Incorporating 2-(2-Hydroxybenzylideneamino) Isoindoline-1,3-Dione and Fluoro-Phenanthroline Derivatives

Growth, structure, spectral and optical properties of semiorganic crystal: Pyridine-1-ium-2-carboxylatehydrogenbromide

New bioactive Pt(II) binary and ternary metal complexes with guaifenesin drug: Synthesis, geometrical structure, and spectroscopic and thermal characterization

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