Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes

Abstract

Ni(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3), and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4). All the complexes were characterized in the light of elemental analysis, molar conductance, FTIR, UV-VIS, magnetic, thermal, powder XRD, and SEM studies. The conductance and spectroscopic data suggested that, the ligands act as neutral and monobasic tridentate ligands and form octahedral complexes with general formula [M(L1–4)2]·nH2O (M = Ni(II) and Zn(II)). Metal complexes exhibited pronounced activity against tested bacteria and fungi strains compared to the ligands. In addition metal complexes displayed good antioxidant and moderate nematicidal activities. The cytotoxicity of ligands and their metal complexes have been evaluated by MTT assay. The DNA cleavage activity of the metal complexes was performed using agarose gel electrophoresis in the presence and absence of oxidant H2O2. All metal complexes showed significant nuclease activity in the presence of H2O2.

Synthesis, characterization, spectroscopic and theoretical studies of transition metal complexes of new nano Schiff base derived from l‐histidine and 2‐acetylferrocene and evaluation of biological and anticancer activities

“…The presence of oxygen and nitrogen in the coordination sphere was further confirmed by the presence of ν(M―O) and ν(M―N) bands which appeared in the ranges 510–560 and 450–488 cm −1 , respectively . The FT‐IR results showed that the Schiff base ligand acted as tridentate chelating ligand as it coordinated to metal ions through nitrogen of azomethine group, oxygen of carboxylate group and nitrogen of imidazole ring.…”

Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes

“…Complex [Zn ( 58 ) 2 ]⋅H 2 O (IC 50 = 0.69 µg/mL) exhibited comparable antioxidant activity to BHT (butylatedhydroxyltoluene) (IC 50 = 0.67 µg/mL), which was a standard drug. The complexes [Ni ( 55 ) 2 ], [Ni ( 58 ) 2 ], and [Zn ( 58 ) 2 ]⋅H 2 O showed moderate antioxidant activity in comparison to the rest of complexes, antioxidant activity of which was weak [ 268 ].…”

Synthesis, Spectroscopic, Structural and Molecular Docking Studies of Some New Nano-Sized Ferrocene-Based Imine Chelates as Antimicrobial and Anticancer Agents

“…Imine ligands with sulfur and nitrogen donor atoms in their structures are effective metal chelating agents and have a wide range of therapeutic applications [ 6 , 7 , 8 ]. Imine compounds produced from 2-aminothiophenol, 2-aminophenol, 2-aminobenzoic acid, and 2-amino-3-hydroxy pyridine, in particular, have antipathogenic activity, inhibition of protein tyrosine phosphatases, and nuclease activity [ 9 ]. These activities could be owing to the inclusion of both hard and soft donor groups in a single ligand, which boosts the potential to coordinate with both hard and soft acidic metals [ 10 ].…”