Synthesis, structural characterization and cytostatic properties of N,N-dicyclohexyldithiooxamide complexes of antimony(III) halides (SbX3, X: Br or I)

Recent advances on antimony(III/V) compounds with potential activity against tumor cells

“…In contrast when the ω-thiocaprolactam (Hthcl) was used as ligand for the preparation of antimony halide compounds, the stronger activity against MCF-7 was observed for the iodide one (Table 2). Thus, both the halogen type and the kind of the ligand were found to affect the cytotoxic activity [15]. The IC 50 values of the complexes 38-41 for the HeLa cells range from 7.7 to 13.6 μM, whereas against the MCF-7 cells vary from 13.0 to 22.4 μM, with a higher activity to be Table 2) it is concluded that the ligand type affects the cytotoxicity of the complex.…”

“…Thus, the conjugated heterocyclic or aliphatic thiones gives more active antimony complexes towards the aromatic ones. Antimony(III) bromide complexes, are less active than the antimony chloride(III) ones against both HeLa and MCF-7 cells [13][14][15][16]. Moreover, the compound 34 with the stronger cytotoxicity activity also inhibits LOX with the stronger manner.…”

“…[11,12] Table 3). The techniques used to characterize the complexes were again, elemental analysis, FT-IR spectroscopy, 1 H, 13 C NMR spectroscopy and thermal gravimetry-differential thermal analysis (TG-DTA) [13][14][15][16]. Crystal structures of the ligand ω-thiocaprolactam and its complexes 32-41 were determined with single crystal X-ray diffraction analysis.…”

“…Compound 40 is a monomer with octahedral (Oh) geometry around Sb(III). Two sulfur atoms and two bromines form a pseudotrigonal-bipyramidal cationic [SbBr 2 (L) 2 ] + part with a bromide as counter anion in complex 41 [13][14][15][16]. NMR spectroscopic studies suggest the retention of the structures of 32-41 in solution.…”

Novel Antimony(iii) Halide Complexes With Some N-Alkyl Thioureas: Synthesis, Characterization and Study of Their Effect Upon the Catalytic Oxidation of Linoleic Acid to Hydroperoxylinoleic Acid by Lipoxygenase

“…melglumineantimoniate (Glucantime) and sodium stibogluconate (Pentostam)) [9]. The potential anticancer activity of antimony compounds is under consideration [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The last studies indicated that antimony(III) compounds are more active against carcinoma than lymphoma [17].…”