Synthesis, structural characterization and evaluation of anticancer activity of polymeric silver(I) complexes based on niflumic acid/naproxen and picoline derivatives

Synthesis, Characterization, Investigation of Anticancer Activity and Molecular Docking Studies of N2O2 Type Schiff Base Ligand and Metal Complexes

“…[35] All literature studies revealed that the anticancer potential of metal complexes is closely related to the strength of the complex formed by the metal with the ligand and its stability in the cell as well as depending on the cell type. [36][37][38][39] The results obtained in our study suggest that although each of the complexes tested exhibited significant anticancer activity against MCF-7 and HT-29 cells, the fact that the cobalt complex exhibited stronger activity than the others led us to believe that this complex may have prolonged stability in the cell because there is no other parameter distinguishing the anticancer potentials of the complexes.…”

Novel Pyrazole‐Based Benzofuran Derivatives as Anticancer Agents: Synthesis, Biological Evaluation, and Molecular Docking Investigations

“…Cell culture, cell growth inhibition, apoptosis, mitochondrial membrane potential (MMP), and caspase activity assays were performed according to the procedures described in our previously published works [25–31] …”

Metal Complexes with Naphthalene-Based Acetic Acids as Ligands: Structure and Biological Activity

“…The polymeric complexes containing 1-naphthylacetato and naproxen ligands are summarized in Table 4 and may be categorized in two groups: (I) the polymeric complexes that are polymerized via the 1-naphthylacetato and naproxen ligands [41,46,59,88,[90][91][92][93] (Table 4, part I), Figure 22) and (II) the polymeric complexes that are polymerized via other co-ligands, and the 1-naphthylacetato and naproxen ligands are just found in the coordination sphere [84,94,95] (Table 4, part II). Most of the reported polymeric complexes bear a monomeric complex as the basis of the polymer with the exception of complexes FUVZIH and CAVHOA which have a trinuclear Cd(II) and a tetranuclear Ag(I) complex, respectively, as the repeating unit of the polymeric structure.…”

“…In the first group of the complexes, where the 1-naphthylacetato and naproxen ligands are the polymerizing linkers (Table 4 [46] and two bidentate µ 2 -O,O naproxen ligands which are forming bridges between the Ag(I) of the repeating tetranuclear unit in complex CAVHOA [93]. In the first group of the complexes, where the 1-naphthylacetato and naproxen ligands are the polymerizing linkers (Table 4, part I), the ligands are in either bidentate µ2-O,O′ or tridentate µ2-O,O,O′ bridging modes.…”

“…Only in the case of complex [Mg(µ2-NAP-O,O)(µ2-NAP-O,O′)(µ2-H2O)]n, three different linkers were found, i.e., bidentate µ2-NAP-O,O, bidentate µ2-NAP-O,O′ and µ2-H2O [41]. Besides the role of the polymerizing linker, there is a bidentate chelating naproxen ligand in complex [Cd(NAP-O,O′)(µ2-NAP-O,O,O′)(H2O)]n [46] and two bidentate µ2-O,O′ naproxen ligands which are forming bridges between the Ag(I) of the repeating tetranuclear unit in complex CAVHOA [93].…”