Synthesis, structural characterization, and evaluation of cyanidin-3-O-glucoside-loaded chitosan nanoparticles

Sun, Jianxia; Chen, Jiali; Mei, Zhouxiong; Luo, Ziying; Ding, Lijun; Jiang, Xinwei; Bai, Weibin

doi:10.1016/j.foodchem.2020.127239

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…macrocarpa , Glycyrrhiza uralensis , Cinnamomum cassia , Malus prunifolia , and Syzygium aromaticum were below 50, while the value of S. aromaticum was only 3.64. However, this does not mean that the use values of these species are low, only that they are not as accepted as P. mume , C. speciosa , or other species in the Bai community, while they may be of great significance in other communities or fields [ 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

Meizi-Consuming Culture That Fostered the Sustainable Use of Plum Resources in Dali of China: An Ethnobotanical Study

Fan

Cheng

Zhang

et al. 2022

Biology

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Prunus mume has been cultivated for more than three millennia with important edible, ornamental, and medicinal value. Due to its sour taste, the Prunus mume fruit (called Meizi in Chinese and Ume in Japanese) is not very popular compared to other fruits. It is, however, a very favorite food for the Bai people living in Eryuan County, Dali of Yunnan, China. The local people are masters of making various local products with plum in different ways. In this research, we conducted field investigations in Eryuan County using ethnobotanical methods from August 2019 to July 2021, focusing on the Prunus mume (for its edible fruits). A total of 76 key informants participated in our semi-structured interviews. The survey recorded 37 species (and varieties) belonging to 11 families related to the Bai people’s Meizi-consuming culture. Among them, there are 14 taxa of plum resources, including one original species and 13 varieties. These 37 species are either used as substitutes for plum due to their similar taste or as seasonings to improve the sour taste of plum. The higher Cultural Food Significance Index value implies that Prunus mume, Chaenomeles speciosa, Phyllanthus emblica, Prunus salicina, and Chaenomeles cathayensis have high acceptance and use value in the Bai communities. Among the various local products traditionally made by the Bai people, carved plums, preserved plums, perilla-wrapped plums, and stewed plums are the most famous and popular categories in the traditional markets. Currently, the plum business based on the traditional Meizi-consuming culture of the Bai people is already one of Eryuan’s economic pillars. This study showed that plums play an important role in expressing the local cultural diversity, and they also help the local people by improving their livelihood through their edible value. In turn, for the sustainable use of plum resources, the Bai people positively manage local forests through a series of measures to protect the diversity of plum resources and related plant communities.

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Section: Resultsmentioning

confidence: 99%

Meizi-Consuming Culture That Fostered the Sustainable Use of Plum Resources in Dali of China: An Ethnobotanical Study

Fan

Cheng

Zhang

et al. 2022

Biology

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“…Further, CMC polymers form stable bonds between NH 3 + and COO − groups. In anthocyanin mixed CMC-Ca matrix, anthocyanins form electrostatic interactions with NH 3 + and COO − groups of CMC ( Figure 9(a) 1–4 bonds) [ 21 , 35 , 36 ]. It is further shown that anthocyanins can incorporate into CMC through its C=O group of the benzopyran aromatic ring [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…The inverse association between encapsulation efficiency and loading capacity in CMC may be due to the variation of the binding capacity of anthocyanin on the CMC-Ca matrix. The carboxylate ion (COO − ) groups of CMC interact with divalent calcium ions (Ca 2+ ) and form 9(a) 1-4 bonds) [21,35,36]. It is further shown that anthocyanins can incorporate into CMC through its C=O group of the benzopyran aromatic ring [37].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the anthocyanin release rate from CMC nanoparticles is pH-dependent. For instance, the C3G release rate from C3G encapsulated CMC-Ca particles is higher (60% over six days period) under acidic conditions (pH 5.3) compared to the slightly acidic or neutral pH (20-Oxidative Medicine and Cellular Longevity 30% over six days, pH 6-8-7.4) solutions [35]. CMC has low solubility at higher pH [50].…”

Section: Discussionmentioning

confidence: 99%

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Anthocyanin Encapsulated Nanoparticles as a Pulmonary Delivery System

Amararathna

Rupasinghe

2022

Oxidative Medicine and Cellular Longevity

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Anthocyanins are known for their therapeutic efficacy for many human diseases, including cancer. After ingestion, anthocyanins degrade due to oxidation and enzymatic breakdown, resulting in reduced therapeutic efficacy. Direct delivery to target tissues and entrapment of anthocyanins increases their stability, bioavailability, and therapeutic efficacy. The objective of the present study was to develop a direct delivery system of anthocyanins into pulmonary tissues via encapsulated nanocarriers. A cyanidin-3-O-glucoside (C3G)-rich anthocyanin extract was prepared from well-ripened haskap (Lonicera caerulea L.) berries (HB) and encapsulated in three different polymeric nanocarrier systems: polyethylene glycol-poly(lactide-co-glycolide), maltodextrin, and carboxymethyl chitosan (CMC). The anthocyanin encapsulation efficiency was significantly higher in CMC (10%) than in the other two polymers. The cytotoxicity and cytoprotective effect of HB anthocyanin-encapsulated CMC (HB-CMC, 4 μg of C3G equivalent anthocyanin in 2 mg/mL nanoparticle) and anthocyanin-free CMC (E-CMC, 2 mg/mL) were tested for cytotoxicity using human normal lung epithelial BEAS-2B cells. The CMC nanoparticles were not cytotoxic for BEAS-2B cells. The HB-CMC nanoparticles reduced carcinogen-induced oxidative stress in BEAS-2B cells and restored the expression of superoxide dismutase and glutathione peroxidase enzymes. The HB-CMC nanoparticles also reduced carcinogen-induced DNA single-strand breaks and alkaline-labile sites but not the double-strand breaks. The E-CMC, HB-CMC (28 μg C3G equivalent/mouse/day for six days), or the same dose of free HB anthocyanin was administered to A/JCr mice through a nose-only passive inhalation device. C3G and its metabolites, cyanidin, peonidin-3-O-glucoside, and cyanidin-3-O-glucuronide, were detected by UPLC/ESI/Q-TOF-MS in the lungs of mice after one hour of exposure. Therefore, the CMC could be a promising noncytotoxic candidate to encapsulate HB anthocyanin. Direct delivery of anthocyanin to lung tissues enhances tissue retention, slows phase 2 metabolism, and improves therapeutic efficacy.

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“…The nanocomposites of β-CD and carboxymethyl chitosan (CMC), which combine the properties of β-CD and CMC, are a unique encapsulating method for delivering bioactive constituents. The β-CD-EP-CMC nanoparticles used in this investigation had a nearly spherical shape, excellent dispersion, and homogenous morphology [ 49 ]. β-cyclodextrin (β-CD) is a commercial agent applied in the food industry with low toxicity.…”

Section: Different Nanocarriers Of Cyanidin 3- O -...mentioning

confidence: 99%

Nanoencapsulation of Cyanidin 3-O-Glucoside: Purpose, Technique, Bioavailability, and Stability

et al. 2023

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The current growing attractiveness of natural dyes around the world is a consequence of the increasing rejection of synthetic dyes whose use is increasingly criticized. The great interest in natural pigments from herbal origin such as cyanidin 3-O-glucoside (C3G) is due to their biological properties and their health benefits. However, the chemical instability of C3G during processing and storage and its low bioavailability limits its food application. Nanoencapsulation technology using appropriate nanocarriers is revolutionizing the use of anthocyanin, including C3G. Owing to the chemical stability and functional benefits that this new nanotechnology provides to the latter, its industrial application is now extending to the pharmaceutical and cosmetic fields. This review focuses on the various nanoencapsulation techniques used and the chemical and biological benefits induced to C3G.

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Synthesis, structural characterization, and evaluation of cyanidin-3-O-glucoside-loaded chitosan nanoparticles

Cited by 24 publications

References 39 publications

Meizi-Consuming Culture That Fostered the Sustainable Use of Plum Resources in Dali of China: An Ethnobotanical Study

Meizi-Consuming Culture That Fostered the Sustainable Use of Plum Resources in Dali of China: An Ethnobotanical Study

Anthocyanin Encapsulated Nanoparticles as a Pulmonary Delivery System

Nanoencapsulation of Cyanidin 3-O-Glucoside: Purpose, Technique, Bioavailability, and Stability

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