Synthesis, structural characterization andin vitroantiproliferative effects of novel organotin(iv) compounds with nicotinate and isonicotinate moieties on carcinoma cells

Abstract

Novel triorganotin(iv) nicotinates and isonicotinates were successfully synthesized and fully characterized. The preliminary results for their in vitro antiproliferative activity against the mouse colon carcinoma C26 cell line are also reported.

Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation

“…For five-coordinated setups the degree of distortion can be quantitatively defined by parameter τ. 12,48 The values of τ = 0.71 for Ph 3 SnL1a and τ = 0.84 for Ph 3 SnL2 correspond to the distorted trigonal-bipyramidal geometry. 49,50 The sum of the The correlation between experimentally and theoretically determined geometric parameters was evaluated using two statistical parameters: the correlation coefficient (R) and the mean absolute error (MAE).…”

C,O‐Chelated organotin(IV) derivatives as potential anticancer agents: Synthesis, characterization, and cytotoxic activity

“…Considering these aspects, many triorganotin(IV) derivatives with various oxygen‐donor ligands, that is, carboxylic acids (e.g., 4‐methoxyphenylacetic, [ 27 ] trifluoroacetic, [ 28 ] 3,5‐di‐ tert ‐butyl‐4‐hydroxybenzoic, [ 29 ] and nicotinic and isonicotinic acid [ 30,31 ] ), amino‐acids (e.g., 3‐aminobenzoic, [ 32 ] 4‐aminobenzoic, [ 32 ] or 5‐amino‐2‐chlorobenzoic [ 33,34 ] ), or nonsteroidal anti‐inflammatory drugs (NSAIDs) (e.g., indomethacin [ 35 ] and ibuprofen [ 36 ] ) displayed higher cytotoxicity with lower IC 50 values than cisplatin or other standard treatments. [ 19 ]…”

“…C , O ‐Chelating ligands were successfully implemented in organotin(IV) chemistry and not only, as an updated and more versatile version of the well‐known C , N ‐chelating ligand, bearing the [2‐(Me 2 CH 2 )C 6 H 4 ] moiety. [ 37 ] Therefore, a series of organometallic compounds with various p‐block metals or elements (Sn, [ 31,38 ] Se, [ 39 ] Te [ 40 ] ) were prepared starting from the readily available 2‐[(O═CH)C 6 H 4 ]Br ligand in its protected form 2‐[(CH 2 O) 2 CH]C 6 H 4 Br. Tris(2‐formylphenyl)‐stibine and ‐bismuthine were also obtained following alternative synthetic protocols.…”

“…The interest for this C , O‐ chelating ligand increases recently owed to its ability to generate organometallic Schiff‐bases via facile condensation reactions with primary amines, [ 38a,b,f ] along with catalytic or biological properties found for some derivatives. [ 31,42 ]…”

Syntheses, structures, in vitro cytostatic activity and antifungal activity evaluation of four diorganotin(iv) complexes based on norfloxacin and levofloxacin

“…[5][6][7] Meanwhile, some organotin carboxylates also have shown high biological activities in terms of their antitumor, antibacterial, antileishmanial and antifungal efficacies. [8][9][10][11] For example, reported by Sirajuddin et al, diphenylstannanediyl bis 2-(4-methoxy-2-nitrophenylcarbamoyl)benzoate showed significant in vitro anticancer activity for H-157 cell lines and antileishmanial activity. 12 In another example, reported by Dahmani et al, di-n-butyltin oxide bipyrazoledicarboxylate macrocyclic complexes showed high antifungal activity for Fusarium oxysporum f. sp.…”