Synthesis, structural characterization, and prospects for new cobalt (II) complexes with thiocarbamoyl-pyrazoline ligands as promising antifungal agents

Antibacterial Activity of Co(III) Complexes with Diamine Chelate Ligands against a Broad Spectrum of Bacteria with a DNA Interaction Mechanism

“…showed strong antifungal activity, especially against C. glabrata (MIC 16 µg/mL) [5]. The similar results presented Dias et al (2020) against Candida glabrata strains treated with Co(II) complexes with thiocabamoyl-pyrazoline ligands with an MIC from 3.9 to 15.62 µg/mL [24]. In this research, tested compounds were shown to present anti-bacterial activity against a broad spectrum of bacteria, and no significant differences in the sensitivity of the Grampositive and Gram-negative bacteria to the test compounds were observed.…”

“…Complexes of platinum (cisplatin), gold (auranofin used in therapy of rheumatoid arthritis), rhenium (radiopharmaceutical used in imaging and radiotherapy), ruthenium (anticancer drugs) or cobalt, lithium, bismuth, iron, calcium, copper, and zinc have been used in medicine [9][10][11][12][13][14]. Recently, the interest in cobalt coordination complexes, especially Co(III) complexes, due to their antimicrobial and antitumor properties has grown [15][16][17][18][19][20][21][22][23][24].…”

New Pyrazoline Derivatives Containing Imine Moiety: Synthesis, Characterization and Antimicrobial Study

“…Chalcone derivative 1 was prepared by the reaction of 4-aminoacetophenone with 4pyridinecarboxaldehyde in ethanol, in a presence of sodium hydroxide 40% solution according to Claisen-Schmidt condensation, while the pyrazoline compound (2) was obtained by the reaction of chalcone compound (1) with hydrazine hydrate 80% in ethanol. Schiff's bases (3)(4)(5)(6)(7)(8) were synthesized from the reaction of compound 2 with different aromatic aldehydes in acidic ethanolic solution, while the pyrazoline derivatives (9 and 10) were prepared by the reaction pyrazoline derivative (2) with the corresponding anhydride (maleic or phthalic anhydride) in glacial acetic acid in a presence of anhydrous sodium acetate (Scheme 1). The structures of obtained compounds were confirmed by spectral analysis (see experimental section).…”

“…The development of heterocyclic chemistry is very rapid, especially in the development of synthetic methods and the biological activity of synthetic materials [3]. Pyrazoline has been widely incorporated into the structure of many important medical and biochemical reagents that have been effectively utilized as anti-bacterial [4], anti-inflammatory [5], anti-viral [6], anti-fungal [7], anti-cancer [8], analgesic and insecticidal agents [9]. In the last few years, a significant and important portion of research in the field of heterocyclic chemistry has been dedicated to pyrazolines and their derivatives, especially those linked by various functional groups such as imine group (Schiff's-Base).…”

“…Therefore, great importance appeared in studying the biological effects of these kinds of derivatives due to their activity against several pathogenic bacteria and fungi [10], this encouraged us to synthesize a new series of pyrazoline derivatives. The synthesized compounds (3)(4)(5)(6)(7)(8)(9)(10) were screened against some bacterial species (gram positive and gram negative) and fungal against (Candida albicans) and the screened results showed moderate to high efficacy.…”