Synthesis, structural, pharmacological and molecular docking simulations studies of some transition metal complexes

Soundaranayaki, V.; Kulandaisamy, A.; Arunadevi, Alagarraj

doi:10.1016/j.inoche.2020.108271

Cited by 9 publications

(5 citation statements)

References 6 publications

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“…Soundaranayaki et al . [ 51 ] developed a series of transition metal complexes 167 – 171 by reacting metal chlorides with a Schiff base derivative of 4-aminoantipyrine. The ligand was prepared by refluxing benzalidene-4-iminoantipyrine with tyrosine.…”

Section: Transition Metal Complexes Of 4-aminoantipyrine Derivatives ...mentioning

confidence: 99%

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

et al. 2022

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Transition metal complexes of 4-aminoantipyrine derivatives have been gaining great interest due to their rich coordination chemistry and potential applications in the field of pharmaceutical science. The presence of a free amine and a cyclic ketone functionality makes 4-aminoantipyrine an attractive amphoteric substrate for Schiff base formation. Varieties of aldehydes/ketones or amines of versatile steric, electronic and functional nature could be condensed with the 4-aminoantipyrine motif to obtain the ligand systems of multi-denticity and diverse coordination behaviour. The transition metal complexes obtained from these ligand systems exhibit unique structural and functional properties. This review compiles the important transition metal complexes developed from the Schiff base derivatives of 4-aminoantipyrine, and their utility as antibacterial and antifungal agents. Rationale of the strategies involved in the development of highly potential antimicrobial agents is discussed.

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Section: Transition Metal Complexes Of 4-aminoantipyrine Derivatives ...mentioning

confidence: 99%

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

et al. 2022

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“…Amoxicillin -Histidine ternary system, (e) Eu(III)-Amoxicillin-Histidine ternary system, (f) Tb(III) -Amoxicillin- Distribution curves of all the binary and ternary systems of Cu(II), Co(II), Ni(II), Zn(II), Eu(III), and Tb(III) were drawn by the HYSS computer program and are given in Figures (7)(8)(9)(10)(11). In figure (7): metal ions were 100% at the beginning, as reaction proceeded and pH increased, its concentration decreased and binary complexes started to form and had grown until reached maximum values (50% at pH 5.9),(70%,pH 7.5),(80%,pH 7.5),(70%,pH 7), (70%,pH 6.5) and (30%, pH 6.5) for (Cu(II), Co(II), Ni(II), Zn(II), Eu(III) and Tb(III)-Ala binary systems respec tively, while binary systems of amoxicillin reached maximum values (70%, pH 7.7), (20%,pH 8.2), (20%, pH 8.5), (10%,pH 8), (25%,pH 7.5) and (15%,pH 7.1) for (Cu(II), Co(II), Ni(II), Zn(II), Eu(III) and Tb(III) respectively.…”

Section: Glycine Ternary Systemmentioning

confidence: 99%

“…In recent years, the chemistry of β-lactam antibiotics about their bioactivities has been of considerable interest [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

Abdelhameed

Orabi

Abbas

et al. 2021

Advances in Environmental and Life Sciences

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Antibiotics have saved countless lives and continue to be the backbone for treating bacterial infections. β-Lactam antibiotics have been successfully introduced as antibacterial agents in the early 1950s. They are still the most popular drugs for treating bacterial infections of many diseases. As a result, the biological applications of these compounds and their complexes have attracted remarkable of metal ions (Cu (II), Co (II), Ni (II), Zn (II), Eu (III), and Tb (III) with amoxicillin(H 2 Ax) (Ax) and some selected amino acids (L-glycine (Gly), L-methionine (Met), L-asparagine (Asn), L-histidine (His) and DL-alanine (Ala) have been investigated potentiometrically, 0.1M KNO 3 ionic strength, in an aqueous medium at 20 o C. The dissociation constants and formation constants of ligands and their metal complexes were calculated from potentiometric data using the Irriving-Rossotti method. The acid-base characteristics of ligands have been examined and discussed. It was found that complexes It has been found that amoxicillin does as a primary ligand for the interaction of metal ions in the presence of glycine, alanine, or histidine amino acids. On the other hand, in the case of methionine or asparagine, amoxicillin acts as a secondary ligand. Stabilities of ternary complexes to metal ions were in the following order: Zn(II)< Cu(II) > Ni(II) >Co(II) for transition metal ions and Eu(III) > Tb(III) for lanthanide metal ions. The concentration distribution curves of the binary and ternary complexes formed in the solution were evaluated as a function of pH using the HYSS program.

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“…Schiff base ligands have gained tremendous attention due to their simple synthesis, strong metal chelating ability, adaptability, and diverse applications. Schiff bases are termed “special ligands” due to their wide range of biological and pharmacological activities [1] like antifungal, [2,3] antidiabetic, [4,5] anti‐inflammatory, [6,7] antibacterial, [8,9] analgesic, [10] antitubercular, [11,12] anticancer, [13–15] and antiasthmatic [16] . The enhanced pharmacological properties of these compounds are due to the presence of electron availability on imine nitrogen, which makes them favourable for complexation with donor heteroatoms (nitrogen, sulphur, oxygen) in combination with different metal atoms connected to pharmacological active complexes.…”

Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental In‐vitro Studies of Novel Thiophene Based Organotellurium(IV) Complexes

Bhardwaj,

Kumar,

Bendi

et al. 2024

Chemistry & Biodiversity

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Schiff bases are one of the important classes of organic compounds containing imine or azomethine functional groups with potential biological applications in medicinal chemistry. These bases played a significant role in developing inorganic, bioinorganic, and optical materials and coordination complexes. Nowadays, these compounds have attracted the scientific community's attention due to their ability to act as ligands in the formation of stable metal complexes with significant biological activity. In this connection, we have designed and synthesized some novel thiophene‐based organoltellurium (IV) complexes using a novel N‐((5‐methylthiophen‐2‐yl) methylene)‐2‐nitroaniline (5MTCONA) schiff base. The synthesized schiff base and organotellurium complexes were characterized with FT‐IR, Mass spectrometry, 1H NMR, 13C NMR, Powder XRD, and TGA. The in‐vitro pharmacological evaluation of these compounds has been carried out as antimicrobial and antioxidant agents. The theoretical studies (Semi empirical PM3 method, Molecular Docking, and ADMET) of all the compounds have also been carried out with Spartan‐14, Hex‐8.0., Swiss ADME software to support the experimental investigations and observed that both the results are in correlation with each other.

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Synthesis, structural, pharmacological and molecular docking simulations studies of some transition metal complexes

Cited by 9 publications

References 6 publications

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

Theoretical and Experimental In‐vitro Studies of Novel Thiophene Based Organotellurium(IV) Complexes

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