Synthesis, structural, photo-physical properties and DFT studies of some diarylheptanoids

Al-Balushi, Rayya A.; Al-Busaidi, Idris Juma; Al-Sharji, Houda; Haque, Ashanul; Faizi, Md. Serajul Haque; Dege, Necmi; Khan, Muhammad Saad; Mohamed, Tarek A.

doi:10.1016/j.molstruc.2022.133254

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…[46] Al-Balushi and coworkers (2022) have presented synthesis and photo-physical properties of curcumin type diarylheptanoids 15.Knoevenagel condensation of BF 3 -protected 2,4pentanedione 11 furnished BF 2 protected compounds 16 which upon heating yielded linear diarylheptanoids 15 (Scheme 3). [47] Xian Wu and team (2022) reported large scale synthesis of anti-inflammatory linear diarylheptanoids oxyphyllacinol 17, yakuchione A 18, and yakuchione B 19. Starting from the commercially available materials, vinyl Weinreb amide 20 was synthesized in a few steps.…”

Section: Knoevenagel Condensation Reactionmentioning

confidence: 99%

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Recent Advances in the Synthesis of Diarylheptanoids

Sudarshan,

Yarlagadda,

Sengupta

2024

Chemistry An Asian Journal

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In the quest for synthesizing biologically important natural products, medicinal chemists embark on an endless journey. This review focuses on the reports published towards the syntheses of diarylheptanoids, classifying them into linear, tetrahydropyran, diarylether, and biphenyl categories. The synthesis methods for each class from 2013 to 2023 are discussed, providing a comprehensive overview of the advancements in the field. Representative natural product examples are highlighted for each category. The review emphasizes the importance of diarylheptanoids in the realms of chemistry and medicine, showcasing their potential as valuable compounds for medicinal and synthetic chemists.

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Section: Knoevenagel Condensation Reactionmentioning

confidence: 99%

“…Al‐Balushi and coworkers (2022) have presented synthesis and photo‐physical properties of curcumin type diarylheptanoids 15 .Knoevenagel condensation of BF 3 ‐protected 2,4‐pentanedione 11 furnished BF 2 protected compounds 16 which upon heating yielded linear diarylheptanoids 15 (Scheme 3). [47] …”

Section: Linear Diarylheptanoidsmentioning

confidence: 99%

Recent Advances in the Synthesis of Diarylheptanoids

Sudarshan,

Yarlagadda,

Sengupta

2024

Chemistry An Asian Journal

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“…Te previous reports showed the suitability of the mentioned basis set for such calculations [30]. Also, the key parameters for reactivity descriptors are calculated by the following formula [31][32][33][34].…”

Section: Teoreticalmentioning

confidence: 99%

An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study

Siadati¹,

Soheilizad²,

Firoozpour

et al. 2022

Journal of Chemistry

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In this report, we have presented our experience about a facile method for synthesis of tofacitinib citrate (TFC). The developed analytical methods for identification and qualifications are also included. As TFC seems to be effective in treatment of the symptoms of COVID-19 (SARS family), manufacturing of this active pharmaceutical ingredient (API) could be helpful. The API of TFC was prepared from the diamine intermediate in an ambient and solvent-free condition. Elimination of the reaction solvent resulted in decreasing the cost and preventing the rejection of the organic volatile impurity (OVI) test. The final citrate addition step was carried out using water as a solvent (the citrate content was 37.5% by potentiometry). Moreover, the results of the Karl-Fischer (KF) titration analysis was about 0.24%, which showed that the use of water does not increase the water content of the crystal structure.

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