Synthesis, structure and bioactivity of a mononuclear octahedral [Prolinate2-Na(MeOH)4]−H+ complex

Belveren, Samet; Poyraz, Samet; Ülger, Mahmut; Pask, Christopher M.; Döndaş, H. Ali; Sansano, José M.

doi:10.1016/j.ica.2020.119456

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…In this complex, the sodium metal ion has a distorted octahedral environment with a NaNO 5 coordination sphere [32]. Another example is the mononuclear octahedral [Prolinate 2 -Na(MeOH) 4 ] − H + complex, which has a NaO 6 coordination sphere [33]. In this case, the sodium ion is coordinated with four methanol molecules and two prolinate anions as monodentate ligands.…”

Section: Introductionmentioning

confidence: 99%

A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity

Yousri,

El-Faham,

Haukka

et al. 2023

Crystals

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The pincer ligand 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (bpmt) was used to synthesize the novel [Na(bpmt)2][AuCl4] complex through the self-assembly method. In this complex, the Na(I) ion is hexa-coordinated with two tridentate N-pincer ligands (bpmt). The two bpmt ligand units are meridionally coordinated to Na(I) via one short Na-N(s-triazine) and two slightly longer Na-N(pyrazole) bonds, resulting in a distorted octahedral geometry around the Na(I) ion. In the coordinated bpmt ligand, the s-triazine core is not found to be coplanar with the two pyrazole moieties. Additionally, the two bpmt units are strongly twisted from one another by 64.94°. Based on Hirshfeld investigations, the H···H (53.4%) interactions have a significant role in controlling the supramolecular arrangement of the [Na(bpmt)2][AuCl4] complex. In addition, the Cl···H (12.2%), C···H (11.5%), N···H (9.3%), and O···H (4.9%) interactions are significant. Antimicrobial investigations revealed that the [Na(bpmt)2][AuCl4] complex has promising antibacterial and antifungal activities. The [Na(bpmt)2][AuCl4] complex showed enhanced antibacterial activity for the majority of the studied gram-positive and gram-negative bacteria compared to the free bpmt (MIC = 62.5–125 µg/mL vs. MIC = 62.5–500 µg/mL, respectively) and Amoxicillin (MIC > 500 µg/mL) as a positive control. Additionally, the [Na(bpmt)2][AuCl4] complex had better antifungal efficacy (MIC = 125 µg/mL) against C. albicans compared to bpmt (MIC = 500 µg/mL).

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Section: Introductionmentioning

confidence: 99%

A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity

Yousri,

El-Faham,

Haukka

et al. 2023

Crystals

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“…[11][12][13][14] The chemistry of benzoylthiourea compound and its transition metal complexes has attracted interest due to their prospective use in a wide range of applications. Previous studies showed that benzoylthiourea complexes have antimicrobial, [15][16][17][18][19][20][21][22][23] antitumor [24][25][26][27][28] antioxidant, [24,29] cytotoxic [30] and insecticidal [31,32] properties. From a chemistry point of view, a notable feature of benzoylthiourea derivatives is due to its strong donor groups (carbonyl and thioamide), which make them very attractive for a coordination agent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation and biological activities of mixed ligand oxovanadium (IV) complexes derived from N,N‐diethyl‐N′‐para‐substituted‐benzoylthiourea and hydrotris(3,5‐dimethylpyrazolyl)borate

Al‐abbasi

Tahir

Kayed

et al. 2022

Applied Organom Chemis

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A series of oxovanadium (IV) complexes namely, [Tp*VOL1], [Tp*VOL2], [Tp*VOL3], [Tp*VOL4] and [Tp*VOL5] (where Tp = hydrotris(3,5‐dimethylpyrazolyl)borate, HL1 = 1‐benzoyl‐3,3‐diethylthiourea, HL2 = 1‐(4‐chlorobenzoyl)‐3,3‐diethylthiourea, HL3 = 1,1‐diethyl‐3‐(4‐methoxybenzoyl)thiourea, HL4 = 1,1‐diethyl‐3‐(4‐nitrobenzoyl)thiourea, HL5 = N‐(diethylcarbamothioyl)biphenyl‐4‐carboxamide) were prepared and characterised on the basis of mass spectrometry, elemental analysis and spectroscopy techniques (IR, UV–Vis and electron paramagnetic resonance, EPR) and mass spectrometry. The crystal structure of [Tp*VOL3] was elucidated from single crystal X‐ray diffraction study and the crystals adopted a triclinic system with a P‐1 (Z = 2) space group and unit cell parameters of a = 10.4953(4), b = 11.5290(5) and c = 15.0656(7) Å. The cyclic voltammetry showed a reversible oxidation of V (IV)/V(V) at about 0.50 V (vs Fc+/Fc). The HOMO and LUMO of benzoylthiourea were established by theoretical calculation based on DFT level using B3LYP method and a double numeric plus polarisation (DNP) basis set. The in vitro tests for antimicrobial activity showed that the complexes have a moderate inhibitory effect. The complex [Tp*VOL1] exhibited cytotoxic activity against the human hepatocellular carcinoma cell line (HepG2) at the concentration of 20 mg ml−1. However, no cytotoxic activity was observed against the Chang liver cells.

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“…In this study, as a continuation of our work related to organometallic compounds with very low/modest amphiphilic character [ 15 – 17 ], we propose the incorporation of a 3-indolylmethyl group in the ligand and compare the bioactivity results of its corresponding nickel(II) [ 18 ] and palladium(II) [ 19 – 20 ] complexes with the analogous tests obtained in the case of having a benzylic substituent at the same position. Also, DFT calculations are run in order to study the conformational analysis of the synthetized complexes.…”

Section: Introductionmentioning

confidence: 99%

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units

Poyraz¹,

Belveren²,

Aydınoğlu³

et al. 2021

Beilstein J. Org. Chem.

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A series of novel palladium(II) and nickel(II) complexes of multifunctionalized aroylaminocarbo-N-thioylpyrrolinates were synthesized and characterized by analytical and spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans, C. tropicalis, and C. glabrata standard strains. A deep conformational survey was monitored using DFT calculations with the aim to explain the importance of the final conformation in the biological experimental results.

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Synthesis, structure and bioactivity of a mononuclear octahedral [Prolinate2-Na(MeOH)4]−H+ complex

Cited by 5 publications

References 29 publications

A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity

A Novel Na(I) Coordination Complex with s-Triazine Pincer Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis, and Antimicrobial Activity

Synthesis, characterisation and biological activities of mixed ligand oxovanadium (IV) complexes derived from N,N‐diethyl‐N′‐para‐substituted‐benzoylthiourea and hydrotris(3,5‐dimethylpyrazolyl)borate

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units

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