Synthesis, structure and interactions with DNA of novel tetranuclear, [Mn4(II/II/II/IV)] mixed valence complexes

Characterization and DNA-interaction studies of 1,1-dicyano-2,2-ethylene dithiolate Ni(II) mixed-ligand complexes with 2-amino-5-methyl thiazole, 2-amino-2-thiazoline and imidazole. Crystal structure of [Ni(i-MNT)(2a-5mt)2]

“…These values suggest a relatively strong binding of the complexes to CT DNA and are lower than the EB binding affinity for CT DNA, (K b = 1.23 ± 0.07 Â 10 5 M À1 bp À1 ), 46 suggesting that electrostatic and/or intercalative interaction may affect EB partial displacement. 33,34,46,47 The intrinsic binding constant (K b ) obtained for complex 3 (=4.94 ± 0.05 Â 10 4 M À1 ) is higher than the other two complexes indicating its stronger ability to bind to CT DNA. 38 …”

Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex

“…Generally, the hypochromism effect in UV study reveals their intercalative binding strength attributed to an interaction with DNA bases [27,28]. Similarly, a hyperchromic effect ascribed to an external contact or to a partial uncoiling of DNA structure, exposing more bases of DNA may be due to electrostatic binding [29,30]. Such observations have been noticed in present study where a significant hypochromic effect in absorption titrations of DNA with PdBA exposed an intercalation with the base pairs of DNA [28,31] (Figure 5a).…”

“…Such observations have been noticed in present study where a significant hypochromic effect in absorption titrations of DNA with PdBA exposed an intercalation with the base pairs of DNA [28,31] (Figure 5a). The decrease in UV absorption predicted the stronger interactions of PdBA whose intercalating strengths was dependent on size and electron densities of interacting aromatic rings as side arm with an amine group [27][28][29][30]. Through UV spectrophotometric titration the PdBA+DNA binding constant (Kb) were 1 × …”

A Dimetallic Osmium(II) Complex as a Potential Phototherapeutic Agent: Binding and Photocleavage Studies with Plasmid DNA

“…/[Os], ε b and ε f are the molar absorptivities of the fully bound and free form of the diOs II complex, respectively. [16] [DNA]/(ε a - The ratio of the slope in Figure 4B to the intercept gives the binding constant K b . A value of 1.70 Ϯ 0.53 ϫ 10 5 m -1 with a confidence interval of 90 % indicates a strong interaction between the di-Os II complex and DNA.…”