Synthesis, structure, spectroscopic and in vitro anti-tumor properties of triazolium salts of cis- and trans-tetrachlorobis(triazole)ruthenate(III)

Arion, Vladimir B.; Reisner, Erwin; Fremuth, Madeleine; Jakupec, Michael A.; Keppler, Bernhard K.; Kukushkin, Vadim Yu.; Pombeiro, Armando J. L.

doi:10.1016/s0162-0134(03)80556-1

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chelating ligands containing N, N, O and S donor atoms show broad biological activity and are of special interest because of the ways in which they are bonded to the metal ions 11 . It is known that existence of metal ions bonded to biologically active compounds may enhance their activities [12][13][14] . In view of importance of above, these two scaffolds are selected in the preparation of ligand using butanol medium.…”

Section: Research Articlementioning

confidence: 99%

Experimental and Theoretical Investigation of 3D-Metal Complexes Derived from N-(1H-Benzimidazol-2-yl)-2-mercaptoacetamide Derivative

2019

Chem Sci Trans

View full text Add to dashboard Cite

New trinuclear metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with N-(1Hbenzimidazol-2-yl)-2-mercaptoacetamide (BMA) were synthesized from chloride salts of relative metals in butanol medium. Synthesized metal complexes were characterized by elemental analysis, conductance measurements, IR, UV-Vis, ESR, TGA & DTA and magnetic susceptibility measurements. IR spectral data suggest that the ligand behaves as monobasic tridentate (NOS) with donor sites of azomethine nitrogen (ring), oxygen atom of carbonyl group and thio group. Physicochemical data suggest tetrahedral geometry for Co(II), Ni(II) and Zn(II) complexes. Square planar intended for Cu(II) complex and all these complexes exhibits non-elecrolytic nature. The complexes were evaluated for their antimicrobial activity by in-vitro antimicrobial screening against bacteria Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Klebsiella Pneumonia. The results indicate that antimicrobial activity increased during metallation. A detailed analysis is done theoretically using DFT method with B3LYP/6-311G/LanL2DZ functional for ligand and complexes. Docking studies of ligand and metal complexes carried out using OPLS 2005 force field in Schrodinger suite.

show abstract

Section: Research Articlementioning

confidence: 99%