Synthesis, structure, terahertz spectroscopy and luminescent properties of copper(I) complexes with mercaptan ligands and triphenylphosphine

Qiu, Qi–Ming; Liu, Min; Li, Zhongfeng; Jin, Qiong‐Hua; Huang, Xiaodong; Zhang, Zhenwei; Zhang, Cunlin; Meng, Qing-Xuan

doi:10.1016/j.molstruc.2013.12.076

Cited by 25 publications

(3 citation statements)

References 67 publications

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“…In the region between 1600–1450 cm –1 , the stretch bands of the CC and C–N bonds overlap . Vibrational modes typical of the triphenylphosphine ligand (P–C aromatic ) and stretching vibrations of the Cu–P bonds appear in the range of 500–430 cm –1 . − …”

Section: Resultsmentioning

confidence: 94%

Experimental and Theoretical DFT Study of Cu(I)/N,N-Disubstituted-N′-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells

et al. 2021

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Six complexes with the general formula [Cu(acylthioureato)(PPh3)2] were synthesized and characterized using spectroscopic techniques (IR, UV/visible, and 1D and 2D NMR), mass spectrometry, elemental analysis, and X-ray diffraction. Interpretation of the in vitro cytotoxicity data of Cu(I) complexes took into account their stability in cell culture medium. DFT calculations showed that NMR properties, such as the shielding of carbon atoms, are affected by relativistic effects, supported by the ZORA Hamiltonian in the theoretical calculations. Additionally, the calculation of the energies of the frontier molecular orbitals predicted that the structural changes of the acylthiourea ligands did not cause marked changes in the reactivity descriptors. All complexes were cytotoxic to the evaluated tumor cell lines [MDA-MB-231 (triple-negative breast cancer, TNBC), MCF-7 (breast cancer), and A549 (lung cancer)]. In the MDA-MB-231 cell line, complex 1 significantly altered the cytoskeleton of the cells, reducing the density and promoting the condensation of F-actin filaments. In addition, the compound caused an increase in the percentage of cells in the fragmented DNA region (sub-G0) and induced cell death via the apoptotic pathway starting at the IC50 concentration. Taken together, the results show that complex 1 has cytotoxic and apoptotic effects on TNBC cells, which is a cell line originating from an aggressive, difficult-to-treat breast cancer.

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Section: Resultsmentioning

confidence: 94%

Experimental and Theoretical DFT Study of Cu(I)/N,N-Disubstituted-N′-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells

et al. 2021

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“…These results are in agreement with the recent work of Jin et al, who showed the formation of copper(I) complexes by chelation of the nitrogen atom of a thiazole. [17] On the contrary, the signals displayed by nitrogen atoms in the spectra of L1 and CuL1 were very different ( Figure 7). A deconvolution of the "N-L1" signal led to three peaks with the same area.…”

Section: Determination Of the Atoms Chelating The Metalmentioning

confidence: 93%

Synthesis and Characterization of a Stable Copper(I) Complex for Radiopharmaceutical Applications

Bodio¹,

Boujtita²,

Julienne³

et al. 2014

ChemPlusChem

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Plantazolicin A, a linear decacyclic natural product, exhibits desirable selective activity against the causative agent of anthrax toxicity. The total synthesis of plantazolicin A and its biosynthetic precursor plantazolicin B was successfully achieved by an efficient, unified, and highly convergent route featuring dicyclizations to form 2,4‐concatenated oxazoles and the mild synthesis of thiazoles from natural amino acids. This report represents the first synthesis of plantazolicin B and includes the first complete characterization data for both natural products.

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“…[38,39] . 因此, 太赫兹光谱是一种用来区别和确定有机- [40,41] . bearing 1,10-phenanthroline and 1,3-bis(diphenylphosphino)propane…”

Section: 配合物1~5的太赫兹光谱mentioning

confidence: 99%

Structures and photophysical properties of copper(I) complexes bearing 1,10-phenanthroline and 1,3-bis(diphenylphosphino)propane

Lin¹,

Fan²,

Guo³

et al. 2017

Sci. Sin.-Chim

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In this work, five [Cu(dppp)(phen)]X complexes (X=BF4 (1), SO3CF3 (2), NO3 (3), SCN (4), I (5)) have been synthesized from 1,10-phenanthroline (phen) and 1,3-bis(diphenylphosphino)propane (dppp) ligands, which show strong phosphorescence between 560-600 nm in the solid state at room temperature. Complexes 1-5 show a broad solid state emission in the green region of the spectrum. As commendable emitter, complex 5 exhibits extraordinary quantum yield (Φp) as high as 18% with lifetime (τp) of 10.1-11.2 μs at room temperature. Time-dependent density functional theory calculation (TD-DFT) was performed on complexes 1~5 to rationalize their experimental absorption and emission spectra. Complex 2 displays a favorable π-π stacking and can be simplified as two-dimensional topology.

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Synthesis, structure, terahertz spectroscopy and luminescent properties of copper(I) complexes with mercaptan ligands and triphenylphosphine

Cited by 25 publications

References 67 publications

Experimental and Theoretical DFT Study of Cu(I)/N,N-Disubstituted-N′-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells

Experimental and Theoretical DFT Study of Cu(I)/N,N-Disubstituted-N′-acylthioureato Anticancer Complexes: Actin Cytoskeleton and Induction of Death by Apoptosis in Triple-Negative Breast Tumor Cells

Synthesis and Characterization of a Stable Copper(I) Complex for Radiopharmaceutical Applications

Structures and photophysical properties of copper(I) complexes bearing 1,10-phenanthroline and 1,3-bis(diphenylphosphino)propane

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