A novel ZnCl 2 -promoted three-component reaction strategy for the synthesis of hexahydrochromeno [2,3-b]quinoline derivatives via the Aldol condensation/Michael addition/cycloaddition/dehydration cascade reaction of 2-amino-4H-chromen-4-ones, aromatic aldehydes, and cyclohexane-1,3-dione was investigated. This procedure is environmentally friendly, highly efficient, and has a broad scope. The structures of the products obtained were determined based on x-ray diffraction studies.