Synthesizing and Characterizing of Gelatin-Chitosan-Bioactive Glass (58s) Scaffolds for Bone Tissue Engineering

Ahmadi, Zarrin; Moztarzadeh, Fathollah

doi:10.1007/s12633-017-9616-z

Cited by 16 publications

(5 citation statements)

References 30 publications

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“…Additionally, the characteristic peaks of silica in different types of crystal can also be observed in Figure . Specially, the peaks appeared at 21.888, 22.996, 38.448, 42.254, and 48.839°, are characteristic of SiO 2 (JCPDS 51‐1379); the three peaks shown at 19.224, 25.199, and 29.066° are ascribed to the SiO 2 (JCPDS 51‐1593); moreover, the narrow peaks at 27.879 and 28.400° are originated from SiO 2 (JCPDS 51‐1377) . It can be found that the diffraction peaks of SGE‐G, SGE‐G‐N, and SGE‐G‐C were sharper and more intense than that of SGE, indicating the higher crystalline feature, which also confirming adding GPTMS promoted the formation of more silica crystallization.…”

Section: Resultsmentioning

confidence: 95%

Action of silicic acid derived from sodium silicate precursor toward improving performances of porous gelatin membrane

Zhang

Liu

Gao

et al. 2020

J of Applied Polymer Sci

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To gain an insight into understanding how the silica network generated from hydrolysis and condensation of silicic acid, derived from sodium silicate, enhancing hydrothermal stability and mechanical properties of the leather, and particularly which active groups playing a main role for interaction of silica with collagen protein molecules, herein, effects of incorporated amino or carboxyl groups on the properties of silicic acid modified gelatin (GE) membrane were intensively studied. We found when lots of amino groups were introduced by adding a modified melamine, the thermal denaturation temperature, uniformity of pore diameter distribution and mechanical strength of GE membrane distinctly increased, while incorporating plenty of carboxyl groups by adding low polymerization degree acrylic acid polymer, no obvious change of performances of GE film was discovered. In addition, utilization of γ-glycidoxypropyltrimethoxysilane had a positive effect on the porosity and flexibility of GE membrane. Importantly, our results indicated that hydrogen bonding probably played the most important role toward improving performances of porous GE film when treated with silicic acid. These findings are greatly beneficial for developing a chrome-free tanning technology based on silicon containing materials, and are also suggestive for fabricating porous silica-GE hybrid materials using sodium silicate as a precursor.

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Section: Resultsmentioning

confidence: 95%

Action of silicic acid derived from sodium silicate precursor toward improving performances of porous gelatin membrane

Zhang

Liu

Gao

et al. 2020

J of Applied Polymer Sci

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“…The bands at 1442, 1479, and 870 cm −1 represent the formation of a carbonate apatite type B, because CO 3 2− has been substituted for PO 4. 3–78 There are two apatite models that contain CO 3 2− : 1) CO 3 2− substitution for PO 4 3− which forms apatite type B, 2) CO 3 2− substitution for OH − and forming apatite type A 79 . The intensity of peaks in the pastes containing 20 wt% GPTMS is higher, suggesting a better cross‐linking and higher bioactivity.…”

Section: Resultsmentioning

confidence: 99%

“…There are numerous studies in the literature which have looked at the role of the three above mentioned constituents with respect to their bio-and tissue engineering behavior. Various studies have been conducted on the compositions based on the chitosan, gelatin and glass including prefabricated scaffolds, [44][45][46][47] coatings 48 using different methods of glass synthesizing methods. 49 It has reported that the setting time is reduced by adding gelatin to a calcium phosphate cement; however, there has been an improvement in the sample's cell activity, cell number, mechanical properties, apatite deposition, cell proliferation, and cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

The influence of 3‐glycidyloxypropyl trimethoxysilane on the rheological and in‐vitro behavior of injectable composites containing64Sbioactive glass, chitosan, and gelatin

Sohrabi

Yekta

Rezaie

et al. 2021

J of Applied Polymer Sci

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The effect of cross‐linker 3‐glycidyloxypropyl trimethoxysilane (GPTMS) on the injectability, bioactivity, rheology, washout resistance, and cellular behavior of bio‐nano composite pastes containing a sol–gel derived bioactive glass (BG), chitosan (Cn), and gelatin (Gel), were studied. The results indicated that the structural integrity of the samples in the stimulated body fluid (SBF) was improved from 80% to 90% with the increase in the GPTMS content. In addition, the viscosity and injectability of the paste were affected, so that the later changed from 96% to 73% and the former changed from 132 × 103 to 210 × 103 Pa.s, with addition of 20 wt% GPTMS. Furthermore, the bioactivity of the pastes was improved with the use of GPTMS. No toxicity was observed in the cellular studies of the GPTMS containing paste after 7 days, and the cells kept their shape and were attached firmly to the paste surface. The results of the present work showed that the use of GPTMS was beneficial in enhancing the properties of injectable paste.

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“…Due to the fact that bone structure is made up of mineral materials, hydroxyapatite (HA), and bio-glass ceramics are the most popular materials for utilization in bone tissue engineering [46] and also in the hyperthermia approach in bones. [5,[47][48][49][50] Furthermore, they have good biocompatibility and biodegradation, and they can control the rate of drug release.…”

Section: Magnetic Nanoparticles In Bone Sarcoma Hyperthermiamentioning

confidence: 99%

Threatening sarcoma with combinational therapies: Magnetic hyperthermia using nanoparticles

et al. 2023

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Despite technical and fundamental progress in conventional cancer treatment methods, there still exists a vital need for more effective methods to address the current limitations in treatment. Combinational therapies are strategies suggested to enhance the chance of recurrence‐free and disease‐free survival in sarcomas. Among them magnetic hyperthermia has been attracting more and more attention for use in multimodal bone sarcoma treatment. The magnetic hyperthermia supposed to be non‐invasive, more tissue‐specific, and more effective in deep tissues. Magnetic nanoparticles and other active agents can be delivered through various drug delivery administrations to the tumor site and be heated remotely via alternating magnetic fields. Designing favorable drug delivery platforms that contain magnetic particles besides other anti‐tumor agents is a vital key in hyperthermia combinational therapies. Nanomaterials and nanotechnology have been widely engaged for designing efficient platforms in multimodal treatments. The purpose of this review is to discuss the latest designed magnetic nanoparticle platforms in hyperthermia combinational treatment in bone sarcoma.

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Synthesizing and Characterizing of Gelatin-Chitosan-Bioactive Glass (58s) Scaffolds for Bone Tissue Engineering

Cited by 16 publications

References 30 publications

Action of silicic acid derived from sodium silicate precursor toward improving performances of porous gelatin membrane

Action of silicic acid derived from sodium silicate precursor toward improving performances of porous gelatin membrane

The influence of 3‐glycidyloxypropyl trimethoxysilane on the rheological and in‐vitro behavior of injectable composites containing64Sbioactive glass, chitosan, and gelatin

Threatening sarcoma with combinational therapies: Magnetic hyperthermia using nanoparticles

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