“…However, a framework to derive physical and physiological signals from a virtual human round-the-clock as a function of his day-to-day actions and emotions is currently missing. 1 An agent is anything that can be viewed as perceiving its environment through sensors and acting upon that environment through actuators [2]. Such agents, implemented in software, have been reported in our prior work [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19] as well as in others'.…”