Synthetic and biological studies of pyrazolines and related heterocyclic compounds

Yusuf, Mohamad; Jain, Payal

doi:10.1016/j.arabjc.2011.09.013

Cited by 115 publications

(62 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pyrazolines find their application as alkaloids, vitamins, pigments, and so on 18 . Antipyrine (2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) was the first pyrazoline derivative used in the management of inflammation and pain 19 .…”

Section: Introductionmentioning

confidence: 99%

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

Alex

Kumar

2013

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their interminable participation in the field of perpetual research and development of therapeutical active agents. As a consequence pyrazoles became an inevitable core of numerous drugs having diverse activities. The broad spectrum of activities portrayed by the pyrazoles instigated the researchers to modify the pyrazole ring as 4,5-dihydro-1H-pyrazoles commonly known as 2-pyrazolines. The present review is a concerted effort to retrace compounds covered from 2009-till date which owe diverse biological activities to the 2-pyrazoline scaffold and also condenses the retro-synthetic approaches employed for their synthesis. This endeavor culminated in revelation that inhibitory potential varied when the substituents in particular N-substituents of 2-pyrazolines were altered.

show abstract

Section: Introductionmentioning

confidence: 99%

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

Alex

Kumar

2013

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…1 H NMR (400 MHz) and 13 C NMR (100 MHz) spectra were recorded at room temperature on a Bruker Ultra Shield 400 using tetramethylsilane (TMS) as the internal standard and deuterated chloroform (CDCl 3 ) as the solvent. EI-MS were run on a Shimadzu GC-MS 2010 spectrometer, which was operating at 70 eV.…”

Section: Apparatus and Analysismentioning

confidence: 99%

“…Pyrazole and pyrazoline (dihydropyrazoles) derivatives are a class of heterocyclic compounds that have drawn much attention, due to their biological and pharmaceutical activities [1]. A brief survey on the biological activities of various pyrazole and pyrazoline derivatives showed anti-inflammatory [2][3][4][5][6],…”

Section: Introductionmentioning

confidence: 99%

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

et al. 2013

View full text Add to dashboard Cite

A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2-20 min) and good yields (65%-80%).

show abstract

“…These N-acetyl pyrazole derivatives are important precursor for the synthesis of some other pyrazoline based heterocycles such as cyanopyridine 1 indoxacarb 2 carbohydrazide hydrazine, 3 pyrimidine. 4 There are numerous solvent-free or solvent assisted acetylation methods available for the synthesis of N-acetylated pyrazoline derivatives in literature.…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free Synthesis of Some1-Acetyl Pyrazoles

Thirunarayanan¹,

Sekar²

2013

Journal of the Korean Chemical Society

View full text Add to dashboard Cite

ABSTRACT. Some N-acetyl pyrazoles including 1-(3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1 H-pyrazole-1-yl) ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones like substituted styryl 3,4-dichlorophenyl ketones using hydrazine hydrate and acetic anhydride in presence of catalytic amount of fly-ash: H2SO4 catalyst. The yield of these N-acetyl pyrazole derivatives are more than 75%. The synthesised N-acetyl pyrazoline derivatives were characterized by their physical constants and spectral data

show abstract

Synthetic and biological studies of pyrazolines and related heterocyclic compounds

Cited by 115 publications

References 100 publications

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

Solvent-Free Synthesis of Some1-Acetyl Pyrazoles

Contact Info

Product

Resources

About