Synthetic Approaches to the 2005 New Drugs

Sakya, Subas M.; Jin, Li; Liu, Kevin K.‐C.

doi:10.2174/138955707780363800

Cited by 20 publications

(3 citation statements)

References 24 publications

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“…The first edition of the “Synthetic Approaches to New Drugs” series was published in 2004 to cover drugs approved in 2002, featuring 28 drugs. This 20th edition will mark the coverage of over 500 new chemical entities (NCEs) that have been approved since the review was initiated, ranging from 12 to over 40 new approved drugs each year. − …”

Section: Introductionmentioning

confidence: 99%

Synthetic Approaches to the New Drugs Approved During 2021

McInturff,

France,

Leverett

et al. 2023

J. Med. Chem.

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Each year, new drugs are introduced to the market, representing structures that have affinity for biological targets implicated in human diseases and conditions. These new chemical entities (NCEs), particularly small molecules and antibody−drug conjugates, provide insight into molecular recognition and serve as potential leads for the design of future medicines. This annual review is part of a continuing series highlighting the most likely process-scale synthetic approaches to 35 NCEs that were first approved anywhere in the world during 2021. ■ SIGNIFICANCEThis publication presents a synopsis of the synthetic approaches to new drugs that were approved in 2021, based on the largest scale of synthesis that has been disclosed in primary literature and/or patents. This provides a view of the practical synthetic methods that are applicable to drug discovery and development and a holistic perspective on the molecular complexity of novel drug molecules and synthetic methods required to manufacture them.

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Section: Introductionmentioning

confidence: 99%

Synthetic Approaches to the New Drugs Approved During 2021

McInturff,

France,

Leverett

et al. 2023

J. Med. Chem.

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“…1 Inaugurated eight years ago, this annual review presents synthetic methods for molecular entities that were launched in various countries for the first time during the past year. [2][3][4][5][6][7][8] Given that drugs tend to have structural homology across similar biological targets, it is widely believed that the knowledge of new chemical entities and their syntheses will greatly facilitate drug design. In 2009, 51 new products including new chemical entities, biological drugs, and diagnostic agents reached the market, 9 the largest number in the last decade.…”

Section: Introductionmentioning

confidence: 99%

Synthetic approaches to the 2009 new drugs

Liu

Sakya

O’Donnell

et al. 2011

Bioorganic & Medicinal Chemistry

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“…The motivation to write such a review is the same as stated in the previous articles [2][3][4][5]. The motivation to write such a review is the same as stated in the previous articles [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%