Synthetic glycolipids as membrane-bound cryoprotectants in the freezedrying process of liposomes

Mixtures of n-dodecyl-β-d-maltoside and hexaoxyethylene dodecyl ether — Surface properties, bulk properties, foam films, and foams

“…In some patents, surfactants are described which have such "hybrid" head groups, namely glucose and ethylene oxide units [74][75][76]. However, they are rarely studied in detail [77][78][79]. A surfactant with a head group consisting of three ethylene oxide units and an inositol unit is an interesting alternative to the classical glucose units as it has the same molecular formula as conventional hexoses C 6 H 12 O 6 , but a different molecular structure (see Section 6.3 for details).…”

Liposomes as Potential Drug Carrier Systems for Drug Delivery

“…To promote vesicle stability during the freeze-drying process, cycloprotectants [53][54][55], including saccharides (e.g. sucrose, trehalose, and lactose) and their derivatives are employed [56]. Cycloprotectants, especially sucrose because of its high glass transition temperature, are believed to be effective to protect the liposome membranes against possible fracture and rapture that might cause a change in size distribution and a loss of the encapsulated material presumably by forming glasses under the typical freezing conditions used for lyophilization [57].…”

Liposomes as Carriers of Anticancer Drugs

“…To promote the stability of the vesicles during freeze-drying, cryoprotectants, such as saccharides and their derivates (e.g. sucrose, trehalose, hydroxypropyl-β-cyclodextrin (HP--CD), are employed [46,47].…”