Synthetic hydrogels: 1. Hydroxyalkyl acrylate and methacrylate copolymers - water binding studies

Corkhill, Philip H.; Jolly, A.; Ng, Chiong O.; Tighe, Brian

doi:10.1016/0032-3861(87)90021-8

Cited by 162 publications

(82 citation statements)

References 36 publications

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“…12 This interaction acts as cross-links in the membrane and reduces the water content of the membrane. 13 On the other hand, water forms hydrogen bonds with the hydrophilic groups of the polymer and this hydrophilic hydration increases with temperature. The polymer chain should expand entropically with temperature, causing an increase in the capacity for water absorption.…”

Section: Hydration Of Poly(mpc-co-bma) Membranementioning

confidence: 99%

Preparation of Phospholipid Polylners and Their Properties as Polymer Hydrogel Membranes

Ishihara

Ueda

Nakabayashi

1990

Polym J

1,055

819

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A methacrylate monomer having the phospholipid polar group, 2-methacryloyloxyethyl phosphorylcholine (MPC) was prepared by an improved method with good yield. MPC was copolymerized with n-butyl methacrylate (BMA). The polymer membranes were prepared from the poly(MPC-co-BMA) by a solution casting method. The membrane adsorbed water well and became a hydrogel structure even MPC mole fraction in the copolymer was 0.04. The water content of the hydrogel membrane increased with increase of MPC units and rise of temperature. These properties of the hydrogel membrane were attributed to the highly hydrophilic phospholipid polar group in the copolymer. Water soluble organic compounds and proteins whose molecular weights were below 10 4 permeated through the hydrogel membrane. However, the protein could not permeate when the molecular weight was higher than 10 5 • KEY WORDS Phospholipid Polymer; 2-Methacryloyloxyethyl Phosphorylcholine ; Membrane; Hydrogel; Water Content; Temperature Response; Permeation; Biomaterials Phospholipids are the main components of the biomembrane and interesting substances in biological and biomedical field. 1,2 Recently, the phospholipid membrane has been used as a drug carrier, sensor, separation membrane. 3 However, these phospholipid membranes were unstable physically and chemically, because the phospholipids constituting membranes do not bond covalently and have high mobility. To improve the mechanical strength of the phospholipid membranes, phospholipid molecules with polymerizable group were synthesized. 4 ,s (MPC) was synthesized and its copolymerization ability with methyl methacrylate was evaluated. 6 Moreover, the blood compatibility of the poly(MPC-co-MMA)s has been investigated. 7 We have developed new biocompatible materials based on the results that the surface of polymeric material showing good biocompatibility was covered with phospholipid molecules and formed biomembrane-like structure on the material. Therefore, a methacrylate having phosphorylcholine moiety, 2-methacryloyloxyethyl phosphorylcholine Polym.

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Section: Hydration Of Poly(mpc-co-bma) Membranementioning

confidence: 99%

Preparation of Phospholipid Polylners and Their Properties as Polymer Hydrogel Membranes

Ishihara

Ueda

Nakabayashi

1990

Polym J

1,055

819

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show abstract

“…[14][15][16][17] It is generally believed that there are two types of molecular interactions of water molecules in any aqueous polymer solutions; namely, the bound water and free water. 18,19 The former is related to the chain hydration and is able to affect the conformation, while the later does not. Note that the process of LCST transition was entropically favored, the releasing of bound water molecules from the PEI-CCA-water hydrogen bonding led to higher translational entropy.…”

Section: Characterizationmentioning

confidence: 99%

Thermal sensitive fluorescent hyperbranched polymer without fluorophores

Wang

Meng

et al. 2008

J. Polym. Sci. A Polym. Chem.

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“…This restricts the potential use of microemulsions in most applications due to the requirement of a formulation as cheap as possible, characterized by a high proportion monomer/surfactant (Katime et al, 2001). Hoar and Schulman were the first to introduce the concept of microemulsion and to postulate the first mechanism for the formation of a microemulsión (Corkhill et al, 1987). The reason for the formation of a stable microemulsion is to be found in the analysis of the energies present in dispersion, a fact which can be expressed in terms of Gibbs free energy necessary for the formation of a microemulsion (Hoar & Schulman, 1943).…”

Section: Introductionmentioning

confidence: 99%

Nano-Engineering of Complex Systems: Smart Nanocarriers for Biomedical Applications

Guerrero–Ramírez¹,

Katime²

2011

Biomedical Engineering - From Theory to Applications

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Synthetic hydrogels: 1. Hydroxyalkyl acrylate and methacrylate copolymers - water binding studies

Cited by 162 publications

References 36 publications

Preparation of Phospholipid Polylners and Their Properties as Polymer Hydrogel Membranes

Preparation of Phospholipid Polylners and Their Properties as Polymer Hydrogel Membranes

Thermal sensitive fluorescent hyperbranched polymer without fluorophores

Nano-Engineering of Complex Systems: Smart Nanocarriers for Biomedical Applications

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