Synthetic nanoparticle vaccines produced by layer-by-layer assembly of artificial biofilms induce potent protective T-cell and antibody responses in vivo

Powell, Thomas; Palath, Naveen; DeRome, Mary; Tang, Jie; Jacobs, Andrea; Boyd, James G.

doi:10.1016/j.vaccine.2010.10.001

Cited by 38 publications

(52 citation statements)

References 63 publications

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“…In addition to intrinsic component, surface modification is also a routine strategy to modulate the performances of particulate adjuvants [44]. In one of the most typical examples, CD206 antibody was conjugated to the particles to guide their tracking down of DCs.…”

Section: Surface Chemical Groupmentioning

confidence: 99%

Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications

Yue

2015

Vaccine

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Section: Surface Chemical Groupmentioning

confidence: 99%

Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications

Yue

2015

Vaccine

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“…Powell and colleagues investigated the in vivo immunization of mice with LbL nanoparticles with an OVA-epitope peptide incorporated within the LbL layers [134]. Single immunization, either subcutaneously or via the footpad route, elicited an antibody response and a T-cell response characterized by both effector (IFN-g) and Th2 (IL-4) responses.…”

Section: Proteinsmentioning

confidence: 99%

Tailoring Layer-By-Layer Capsules for Biomedical Applications

et al. 2012

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Polymeric capsules have attracted great interest as versatile carrier systems in the area of medicine and pharmaceutics. These capsules are made by stepwise layer-by-layer adsorption of polymers onto a template core, which can be removed to produce hollow capsules. The cavity of these capsules can host various cargo molecules while the capsules' wall can be functionalized towards desired properties by embedding specific moieties into the multilayers. Tuning of the capsules' properties influences their interaction with cells and tissues and paves the way towards the development of stimuli-responsive capsules releasing their payload at a target site. In this review, we describe the generation of tailored layer-by-layer capsules and focus hereby on numerous potential applications of this multifunctional delivery platform in biomedical settings. We review the current status in the field and discuss the opportunities, as well as the hurdles, to be overcome to successfully transfer this technology to therapeutic and diagnostic applications.

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“…Polymeric solutions, micro-or nano-particulates can be used as effective adjuvants either alone [203] or in a complexed form with antigens [204] and/or other adjuvants [205]. Various polymers have been demonstrated to have such properties, such as polylactic acid (PLA), poly (lactide-co-glycolide) acid (PLGA) [206,207], chitosan [208][209][210][211] or modified chitosan [207], poly(-glutamic acid) (-PGA) [212,213], polypeptides [204], starch [214,215], polystyrene [35,205], polyphosphazene [216], poly (prolylene sulfide) [217], polyethylene glycol [218], alginate [219], and their copolymers [220,221].…”

Section: Polymeric Solutions or Particulatesmentioning

confidence: 99%

“…Various polymers have been demonstrated to have such properties, such as polylactic acid (PLA), poly (lactide-co-glycolide) acid (PLGA) [206,207], chitosan [208][209][210][211] or modified chitosan [207], poly(-glutamic acid) (-PGA) [212,213], polypeptides [204], starch [214,215], polystyrene [35,205], polyphosphazene [216], poly (prolylene sulfide) [217], polyethylene glycol [218], alginate [219], and their copolymers [220,221]. They enhance immunogenicity through several mechanisms, including enhancement of antigen uptake by dendritic cells (in vitro) [212], maturation of dendritic cells [212], promotion of proliferation of antigen-specific T cells [212], stimulation of both B and T lymphocytes [208], facilitation of activation of dendritic cells [222], viscosity-induced retention of antigens in the vaccination site [210] and controlled release of antigen by particles [223,224].…”

Section: Polymeric Solutions or Particulatesmentioning

confidence: 99%