Synthetic peptide vaccines

Сергеев, О. В.; Баринский, И Ф

doi:10.18821/0507-4088-2016-61-1-5-8

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…The significance of immunization by vaccination is that it trains the immune system to identify and defend against contagious diseases and provides passive community-level protection by promoting herd immunity [ 1 , 2 ]. Different vaccines such as DNA vaccines, synthetic peptide vaccines, nanovaccines, and recombinant protein vaccines have been created using contemporary biotechnological methods [ 3 , 4 , 5 , 6 , 7 ]. The main goal of these vaccines is to create an immunological response mediated by an antigen against the disease.…”

Section: Introductionmentioning

confidence: 99%

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.

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Section: Introductionmentioning

confidence: 99%

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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show abstract

“…In addition to strengthening the immune system's ability to recognize and defend against infectious diseases, vaccinations also provide a passive level of community safety by promoting herd immunity [5,6]. Biotechnological methods have significantly advanced various vaccinations, such as DNA, recombinant subunits, synthetic peptide, and nanovaccines [3,[7][8][9][10]. These vaccines are intended to trigger an immunological reaction against the pathogen mediated by an antigen.…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Aldaais¹

2023

Preprint

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Due to their distinct physical, chemical, and biological characteristics, biopolymers, in particular Poly Ethylene Glycol (PEG) and Cellulose, are frequently used in biomedical medicine as drug or vaccine delivery systems. In this study, we have done a systematic review and a meta-analysis to compare current developments in many PEG and cellulose-based hydrogels, including double network hydrogels, injectable hydrogels, sliding hydrogels, conductive hydrogels, responsive hydrogels, and nanocomposite hydrogels. The pharmacokinetic properties, including physicochemical properties, biocompatibility, biodegradability, temperature, and pH, have been studied as these critical factors are to be considered for deciding the suitability of the drug for delivery. Moreover, the study has evaluated the controlled-release parameters such as half-life, circulation time, maximum release percentage of loaded drug released, burst release, maximum release, and drug-release kinetics. Finally, the efficacy and immune response of hydrogel was studied for future choice, including the cellulose hydrogel system in COVID-related long-term vaccine delivery. The finding revealed that cellulose-based hydrogel is effective for vaccine delivery.

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“…PCSK9 can bind to low-density lipoprotein receptor and causes its intracellular degradation and reduction of LDLR, which in turn promotes the circulating levels of low-density lipoprotein cholesterol (LDL-C). PCSK9 nanovaccine could target atherosclerosis effectively by producing antibody binding to PCSK9 and forming immune memory safely through active immune response …”

Section: Introductionmentioning

confidence: 99%

PCSK9 Hapten Multicopy Displayed onto Carrier Protein Nanoparticle: An Antiatherosclerosis Vaccine

You

Guo

Xue

et al. 2019

ACS Biomater. Sci. Eng.

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In recent years, various vaccination strategies have shed new light on the treatment of atherosclerosis. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) is a hot target in the development of antiatherosclerosis vaccine. However, the efficacy of conventional PCSK9 is largely limited by poor immunogenicity and low hapten density. Therefore, we hypothesized whether a nanostructure synthesized by self-assembled carrier protein accompanied by multicopy hapten display could improve the efficacy of vaccine. In this study, bovine serum albumin (BSA) was self-assembled into sub-100 nm nanoparticles via an intermolecular disulfide network as the inner core. Then, sequences of PCSK9 were conjugated onto the surface of nanoparticles by “click” chemistry to consequently form an orderly structured of nanovaccine with repetitive hapten display. Compared with conventional PCSK9 peptide vaccine, our immunization study demonstrated that the PCSK9 multicopy display nanovaccine (PMCDN) was able to induce higher titers of PCSK9 antibody and more efficient lymph node drainage and improve endocytosis by antigen presenting cells.

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Synthetic peptide vaccines

Cited by 9 publications

References 29 publications

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

PCSK9 Hapten Multicopy Displayed onto Carrier Protein Nanoparticle: An Antiatherosclerosis Vaccine

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