Synthetic Prostaglandin E1 Misoprostol as a Treatment for Tinnitus

Briner, Wayne; House, John S.; O'Leary, Michael

doi:10.1001/archotol.1993.01880180068013

Cited by 21 publications

(26 citation statements)

References 12 publications

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“…Tinnitus is mostly seen in the age range of 30-70 years throughout life. [8] In our study, the average age of all participants was 49±11; it was within the generally accepted limits.…”

Section: Discussionsupporting

confidence: 68%

“…[8] In the study by Briner et al, [8] the ratio of males to females was 2:42 whereas in the study by Yılmaz et al, [11] this rate was found to be 1:86 and bilateral tinnitus was encountered in 42.5% of patients. The male: female ratio in our study was 2.64 and was consistent with literature.…”

Section: Discussionmentioning

confidence: 93%

“…It is accepted by authorities that tinnitus frequency is generally above 2000 Hz, it peaks between 3000 and 4000 Hz and it is mostly found at 4000 Hz. [11] Briner et al, [8] found the average value of tinnitus frequencies to be 2718 Hz. Yılmaz et al, [11] found the average value of tinnitus frequencies as 5796.67±3017.89 Hz.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of tinnitus with tinnitus severity index, tinnitus handicap inventory and distortion product otoacoustic emissions in patients with normal hearing and hearing loss

Yenigün¹

2014

Kulak Burun Bogaz Ihtis Derg

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Objectives: This study aims to assess ears with tinnitus and without distortion product otoacoustic emissions (DPOAE) in patients with and without hearing loss and to classify the tinnitus symptoms on the basis of tinnitus severity index (TSI) and tinnitus handicap inventory (THI) in both groups. Patients and Methods:A total of 102 patients with tinnitus symptoms were included in the study. Of these patients, 48 had (32 males, 16 females; mean age 45±8.9 years) normal hearing and 54 patients (42 males, 12 females; mean age 52±12.1 years) had hearing loss. Pure tone audiogram, high-frequency audiometer and DPOAE were applied to patients. Tinnitus symptoms of patients were assessed with TSI and THI.Results: Significantly higher tinnitus severity was monitored in group with hearing loss compared with group with normal hearing (p=0.024). There was a significant similarity in the frequencies affected from tinnitus between the groups (p<0.001). The TSI and THI showed significant similar results between two groups (p<0.001). A significant decrease was found in ears with tinnitus in frequencies of 1000 Hz, 2000 Hz, 3000 Hz, 4000 Hz and 6000 Hz with DPOAE compared to the ears without tinnitus in group with normal hearing (p<0.05). Conclusion:Our study results show that patients with TSI and THI are affected by tinnitus at the same rate in daily life whether they have hearing loss or not, but those with hearing loss have a higher tinnitus severity. Decreased DPOAE responses can be found in patients with normal hearing, which can be more profound in low-frequency tinnitus, particularly.Key Words: Distortion product otoacoustic emission; tinnitus; tinnitus handicap inventory; tinnitus severity index.Amaç: Bu çalışmada işitmesi normal olan ve işitme kaybı olan hastalarda tinnitus olan ve distorsiyon ürünü otoakustik emisyon (DPOAE) olmayan kulaklar değerlendirildi ve tinnitus semptomları tinnitus şiddet indeksi (TSI) ve tinnitus handikap envanterine (THI) göre her iki grupta da sınıflandırıldı. Hastalar ve Yöntemler: Çalışmaya tinnitus semptomu olan toplam 102 hasta dahil edildi. Bu hastaların 48'inin (32 erkek, 16 kadın; ort. yaş 45±8.9 yıl) işitmesi normal olup, 54'ünde (42 erkek, 12 kadın; ort. yaş 52±12.1 yıl) işitme kaybı vardı. Hastalara pür ton odyogram, yüksek frekanslı odyometre ve DPOAE uygulandı. Hastaların tinnitus semptomları TSI ve THI ile değerlendirildi. Bulgular: İşitmesi normal olan gruba kıyasla, işitme kaybı olan grupta anlamlı düzeyde daha yüksek tinnitus şiddeti gözlendi (p=0.024). Gruplar arasında tinnitustan etkilenen frekans açısından anlamlı bir benzerlik vardı (p<0.001). Tinnitus şiddet indeksi ve THI, iki grup arasında anlamlı düzeyde benzer bulgular gösterdi (p<0.001). İşitmesi normal olan grupta tinnitus olmayanlara kıyasla, olan kulaklarda DPOAE ile 1000 Hz, 2000 Hz, 3000 Hz, 4000 Hz ve 6000 Hz frekanslarında anlamlı bir azalma saptandı (p<0.05). Sonuç: Çalışma bulgularımız işitme kaybı olsun veya olmasın, TSI ve THI uygulanan hastaların gündelik yaşamda tinnitustan aynı oranda etkilendiğini, a...

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“…Tinnitus is mostly seen in the age range of 30-70 years throughout life. [8] In our study, the average age of all participants was 49±11; it was within the generally accepted limits.…”

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 93%

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Assessment of tinnitus with tinnitus severity index, tinnitus handicap inventory and distortion product otoacoustic emissions in patients with normal hearing and hearing loss

Yenigün¹

2014

Kulak Burun Bogaz Ihtis Derg

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“…However, there have been very few clinical studies. In a clinical trial reported by Briner et al [4], a relatively small number of patients demonstrated a beneficial effect, but long-term results were not apparent from this study. Currently there is no pharmacologic agent that has been approved by the United States Food and Drug Administration for the treatment of tinnitus.…”

Section: Medical Therapiescontrasting

confidence: 67%

Current concepts in the clinical management of patients with tinnitus

Parnes

1997

Eur Arch Otorhinolaryngol

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The current management in tinnitus of sensorineural origin is reviewed. Epidemiological data demonstrates that 90% of patients with hearing loss experience some tinnitus. Approximately 1% of the population suffer from a chronic tinnitus that causes severe distress and requires some type of management intervention. Present non-surgical therapies include masking techniques, psychological counseling, and biofeedback. There are also a number of drugs that have been applied, the most common being antidepressants. These have had the most success in managing patients with tinnitus, although it is currently felt that antidepressants treat underlying psychological problems rather than directly affect the tinnitus. The other large class of drugs include benzodiazopans, in addition to a new synthetic analog of a natural prostaglandin El, misoprostol. Despite the many drugs now available, none has been approved by the United States Food and Drug Administration for the treatment of tinnitus. Many surgical therapies have been advocated but are directed towards the treatment of concurrent vertigo or for tumors of the cerebellopontine angle, with tinnitus sometimes being relieved by the operation. Specific surgical procedures such as cochlear resection and microvascular decompressions lack clear-cut efficacy. Despite author bias and a myriad of treatment modalities at present, there is still no specific therapy that definitively relieves tinnitus clinically.

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“…Tinnitus, a common side effect of high doses of salicylates, has been suggested by some to be due to inhibition of COX-1-dependent synthesis of PGEs by cells of the inner ear. Although conclusive data for this assertion are lacking, several studies have demonstrated the usefulness of PGE 1 analog misoprostal as a therapy for tinnitus [25,26]. Finally, most NSAIDS including aspirin promote salt and water retention, especially when heart or liver disease compromises renal blood flow.…”

Section: Toxic Effects Of Aspirin: the Cox-2 Hypothesismentioning

confidence: 99%

The pleiotropic functions of aspirin: mechanisms of action

Amin

Attur

Pillinger

et al. 1999

Cellular and Molecular Life Sciences (CMLS)

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Recent studies have suggested that aspirin and aspirin-like compounds have a variety of actions in addition to their well-studied ability to inhibit cyclooxygenases. These actions include inhibition of the uncoupling of oxidative phosphorylation, decreases in adenosine triphosphate stores. increases in extracellular adenosine, downregulation of the expression and activity of inducible nitric oxide synthetase, inhibition and/or stimulation of various mitogen-activated protein kinase activities and inhibition of nuclear factor binding kappaB site (NF-kappaB) activation. Moreover, aspirin-like compounds have recently been shown to have previously unappreciated clinical and biological effects, some apparently independent of cyclooxygenase. In this review we discuss the various mechanisms of action of aspirin-like compounds and their relevance to clinical disease and therapy.

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Synthetic Prostaglandin E1 Misoprostol as a Treatment for Tinnitus

Cited by 21 publications

References 12 publications

Assessment of tinnitus with tinnitus severity index, tinnitus handicap inventory and distortion product otoacoustic emissions in patients with normal hearing and hearing loss

Assessment of tinnitus with tinnitus severity index, tinnitus handicap inventory and distortion product otoacoustic emissions in patients with normal hearing and hearing loss

Current concepts in the clinical management of patients with tinnitus

The pleiotropic functions of aspirin: mechanisms of action

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