Synthetic Rat Scotophobin Induces Dark Avoidance in Mice

Malin, David H.; Guttman, Helene N.

doi:10.1126/science.178.4066.1219

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Scotophobin1

Evaluation Of Research Results1

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1972

2011

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Cited by 19 publications

(2 citation statements)

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“…The synthetic peptide was distributed to a number of laboratories, most of whic h conrirmed our results (MALIN and GUTTMAN 1972, BRYANT et al 1972, THINES et al 1973.…”

Section: Scotophobinmentioning

confidence: 52%

Molecular coding of information in the nervous system

Ungar

1972

Naturwissenschaften

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Ev idence has been accumulating in the last ten years t o s~pp o rt the existence o f a molecular code for the processing of in f o r mation by the nerv o us sys t em. The most direct eviden c e has been p r ovided by the behavioral bioassay approach which has led t o the isolation of training-induced and behavio r-i nducing pe p tides (mnemones). The most pro bable role of thes e peptides i s to establish and consolidate t he connections of t he neural ci r cuits in wh i ch info r mation is stored. A lth o ugh this coding pr ocess is based on the gene t ically cont r olled labelin g system by which neurons are o r ganized into spec i f i c pathway s, i t must involve a step of non-genetic pept ide s ynthesis .

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“…The synthetic peptide was distributed to a number of laboratories, most of whic h conrirmed our results (MALIN and GUTTMAN 1972, BRYANT et al 1972, THINES et al 1973.…”

Section: Scotophobinmentioning

confidence: 52%

Molecular coding of information in the nervous system

Ungar

1972

Naturwissenschaften

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show abstract

“…In synthetic state, this chemical was claimed to produce the same effect. A number of other researchers also obtained Significant results (e.g., Bryant, Santos, & Byrne, 1972;Guttman, Mattwyshyn, & Warriner, 1972;Malin & Guttman, 1972;McConnell, personal communication). Other research, however, did not show this effect (e.g., Ali, Faesal, Sarantakis, Stevenson, & Weinstein, 1971;Goldstein, Sheehan, & Goldstein, 1971), and a detailed article by Stewart (1972) raised questions about the overall methodology and conclusions of the scotophobin advocates.…”

Section: Evaluation Of Research Resultsmentioning

confidence: 78%