Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Abstract

Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic\ud endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented\ud here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their\ud antimalarial activity in viv

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

“…Resulting post‐docking minimized poses were scored and ranked by Glide XP. The binding energies were estimated using Prime MM‐GBSA for the complexes 1 c –Zmp1 and 2 a –Zmp1 as described previously …”

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

“…The method was applied on the docking complexes of the ligands developed in the present work. The program was used to assess the free-binding energy (ΔG bind ) as formerly described by us 17 19 34 35 .…”

Mn(OAc)3 catalyzed intermolecular oxidative peroxycyclization of naphthoquinone

“…In addition to the well-known commercial drug artemisinin, 20 trioxolanes arterolane and artefenomel, 21 a wide variety of 1,2-dioxanes showed potential antimalarial activity. [22][23][24][25][26] Quinone derivatives have important biological applications, mainly as anticancer 27 and antiparasitic 28 compounds. The 2-hydroxy-3-alkylnaphthoquinone lapachol derivatives antimalarial activity 29 encouraged us to seek an easily reproducible procedure to obtain chimeric 2-hydroxy-3-alkylnaphthoquinone/endoperoxide molecules.…”