Synthetic strategy of diflurophosphate-bridged bimetallic N-heterocyclic carbene complexes: Synthesis, structures and photoluminescence of picolyl-substituted alkylbenzimidazolylidene ligands

Adhikary, Sirsendu Das; Jhulki, Lalmohan; Seth, Saikat Kumar; Kundu, Arjama; Bertolasi, Valerio; Mitra, Partha; Mahapatra, Ambikesh; Dinda, Joydev

doi:10.1016/j.ica.2011.12.007

Cited by 18 publications

(4 citation statements)

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“…All the synthesized benzimidazolium salts (4a-4j) and their corresponding Ag(I) complexes (5a-5j) were investigated for antibacterial against the gram (+)/(−) bacteria. The DMSO did not exhibit any antimicrobial activity as reported earlier [61][62][63][64][65][66][67][68][69][70][71][72][73].…”

Section: Biological Cytotoxic and Antibacterial Activitiessupporting

confidence: 63%

Novel N-Heterocyclic Carbene Silver (I) Complexes: Synthesis, Structural Characterization, Antimicrobial, Antioxidant and Cytotoxicity Potential Studies

Slimani¹,

Dridi²,

Özdemır³

et al. 2022

Carbene

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Nowadays, N-heterocyclic carbene-based silver-complexes Ag(I) have been widely used as an organometallic drug candidate in medicinal and pharmaceutical chemistry researches due to their low toxicity. Due to the success of Ag(I) complexes in biological applications, interest in the synthesis and applications of such compounds is increasing rapidly. Therefore, in this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j). The interaction of these benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out to afford Ag(I) complexes and characterized by 1H NMR, 13C NMR, FT-IR and elemental analyses. The antimicrobial activity of Ag(I) complexes was tested against some standard culture collections of Gram-negative, Gram-positive bacterial strains and Fungal strains, which are the most frequently isolated among the society and hospital-acquired infectious microorganisms as potential metallopharmaceutical agents. The Ag-NHC complexes showed effective antimicrobial activity against microorganisms with MIC values between 0.0024 and 1.25 mg/ml. Moreover, these Ag-NHC complexes exhibited significant antioxidant activities. In addition, of benzimidazoles salts 2,4 and Ag(I) complexes 3,5 were screened for their antitumor activity. The highest antitumor activity was observed for 3e and 3d Complexes.

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Section: Biological Cytotoxic and Antibacterial Activitiessupporting

confidence: 63%

Novel N-Heterocyclic Carbene Silver (I) Complexes: Synthesis, Structural Characterization, Antimicrobial, Antioxidant and Cytotoxicity Potential Studies

Slimani¹,

Dridi²,

Özdemır³

et al. 2022

Carbene

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“…[2][3][4][5][6] N-heterocyclic carbenes, [1][2][3][4][5][6][7][8] derived from the deprotonation of 1,3 disubstituted imidazolium or benzimidazolium salts by external base or proper choice of metal salt gives the Metal-NHC (M-NHCs), which are used in metal-mediated catalytic reaction with interesting photophysical properties. [2][3][4][5][6][7][8][9][10][11][12] Beyond catalysis, M-NHCs recently contributed interesting results as promising antimicrobial and anticancer drugs. [10][11][12][13][14][15] Though initially the imidazoline NHC ligands comprised N-alkylated derivatives, the file is enriched with N-functionalized NHC by pyridine, pyrimidine, pyrazole, oxazole, thiazole, carbazole, etc.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14][15] Though initially the imidazoline NHC ligands comprised N-alkylated derivatives, the file is enriched with N-functionalized NHC by pyridine, pyrimidine, pyrazole, oxazole, thiazole, carbazole, etc. [2][3][4][5][6][7][8][9]14,15] Most of N-alkylated NHCs acts as mono dentate ligands, whereas incorporation of wingtip such as pyridine/pyrimidine/oxazole/thiazole in the backbone offers either mono-, bi-, or tridentate NHC depending upon the designing of the ligand and choice of metal. As NHC ligand is a strong σ-donor and weak π-acceptor than phosphine, it is used as an alternative of phosphine in catalysis.…”

Section: Introductionmentioning

confidence: 99%

“…[18] Recently, pyrazine-bridged imidazoline or benzimidazoline ligands have been synthesized and used in this study. [6][7][8][9][14][15][16][17][18] A steady growth of interest in Ru(II)-NHC anticancer drugs and photoluminescence study of Ru(II)-NHC complexes over the last 20 years is reflected in the accelerating growth of publications. [13,[19][20][21][22][23] Interestingly, Ru anticancer drugs have been growing rapidly since NAMI-A (ImH+)[RuIIICl4(Im) (S-dmso)], where Im = imidazole and S-dmso = S-bound dimethylsulfoxide) or KP1019 (IndH+)-[RuIIICl4(Ind)2], where Ind = indazole, has successfully completed phase-I clinical trials and an array of other Ru complexes have shown promises for future development.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxic potency of self-assembled Ruthenium(II)-NHC complexes with pincer type 2, 6-bis(N-methylimidazolylidene/benzimidazolylidene)pyrazine ligands

et al. 2015

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The Chemistry of Gold–Metal Bonds

Silvestru

Laguna

2015

Patai's Chemistry of Functional Groups

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This chapter summarizes the preparation, structural characterization and properties of heterometallic gold compounds built through metal–metal interactions or bonds. They are mainly synthesized following four different strategies. Two of them use the acid‐base process with gold precursors acting as acids or organoaurates acting as bases, the third one consists of the use of bidentate bridging ligands, and the fourth uses the isolobal relationship between the [(R 3 P)Au] + cations and the proton in carbonyl clusters. The structural behavior of these complexes has been studied by different methods, mainly Mössbauer spectroscopy, nuclear magnetic resonance spectroscopy, and single‐crystal X‐ray diffraction. Their structures show discrete molecules, extended linear chains or even two‐ or three‐dimensional networks. Many of these complexes display luminescence and the emissions are strongly dependent on their structures. Some theoretical calculations are able to show that the formation of metal–metal interactions or bonds, as well as the gold environments, are the main aspects that affect the energy of the emissions. Other very promising areas of research such as the potential applications in electrochemistry, in biology (antiproliferative and antitumoral activity) or as homogeneous and heterogeneous catalysts are also discussed.

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Synthetic strategy of diflurophosphate-bridged bimetallic N-heterocyclic carbene complexes: Synthesis, structures and photoluminescence of picolyl-substituted alkylbenzimidazolylidene ligands

Cited by 18 publications

References 84 publications

Novel N-Heterocyclic Carbene Silver (I) Complexes: Synthesis, Structural Characterization, Antimicrobial, Antioxidant and Cytotoxicity Potential Studies

Novel N-Heterocyclic Carbene Silver (I) Complexes: Synthesis, Structural Characterization, Antimicrobial, Antioxidant and Cytotoxicity Potential Studies

Cytotoxic potency of self-assembled Ruthenium(II)-NHC complexes with pincer type 2, 6-bis(N-methylimidazolylidene/benzimidazolylidene)pyrazine ligands

The Chemistry of Gold–Metal Bonds

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