Synthetic tissue engineering: Programming multicellular self-organization by designing customized cell-cell communication

Toda, Satoshi

doi:10.2142/biophysico.bsj-2020002

Cited by 7 publications

(5 citation statements)

References 56 publications

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“…From the point of view of modeling, spatial structure introduces complexity in the mathematical representations, as well as increasing the parameter space of models. Our framework provides a simple approach to study the equilibrium properties and can assist in the design of synthetic systems and tissue engineering, as it allows for the prediction of system-level properties from molecular scale parameters [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Global dynamics of microbial communities emerge from local interaction rules

et al. 2022

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Most microbes live in spatially structured communities (e.g., biofilms) in which they interact with their neighbors through the local exchange of diffusible molecules. To understand the functioning of these communities, it is essential to uncover how these local interactions shape community-level properties, such as the community composition, spatial arrangement, and growth rate. Here, we present a mathematical framework to derive community-level properties from the molecular mechanisms underlying the cell-cell interactions for systems consisting of two cell types. Our framework consists of two parts: a biophysical model to derive the local interaction rules (i.e. interaction range and strength) from the molecular parameters underlying the cell-cell interactions and a graph based model to derive the equilibrium properties of the community (i.e. composition, spatial arrangement, and growth rate) from these local interaction rules. Our framework shows that key molecular parameters underlying the cell-cell interactions (e.g., the uptake and leakage rates of molecules) determine community-level properties. We apply our model to mutualistic cross-feeding communities and show that spatial structure can be detrimental for these communities. Moreover, our model can qualitatively recapitulate the properties of an experimental microbial community. Our framework can be extended to a variety of systems of two interacting cell types, within and beyond the microbial world, and contributes to our understanding of how community-level properties emerge from microscopic interactions between cells.

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Section: Discussionmentioning

confidence: 99%

Global dynamics of microbial communities emerge from local interaction rules

et al. 2022

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“…This issue could be addressed by designing cell-cell interactions through a synthetic notch pathway that controls cadherin expression and thus cell migration and organization in 3D spheroids. 60 , 61 In addition to spatial control, precise temporal control of signaling pathways plays an important role in hepatocyte differentiation. For example, BMP signaling is upregulated or downregulated depending on the stage in differentiation.…”

Section: Synthetic Biology Approaches To Mature Hlcsmentioning

confidence: 99%

Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease Modeling

Yuan

Cotton

Samarasekera

et al. 2023

Cellular and Molecular Gastroenterology and Hepatology

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“…Besides direct cell-cell interactions, by engineering natural and/or synthetic mechanisms in tissue-like materials, the role of the native extracellular matrix could also be explored to direct the interactions between cells and/or the surrounding environment [97] using natural or synthetic elements, [98][99][100][101] or cell-like entities can be used to mimic cellular functions. [102][103][104][105][106][107] Via these approaches it should be feasible in the future to fabricate complex tissue dynamics via the interactions between synthetic intelligent units and natural elements. Due to their durable nature, synthetic elements could also be used for tissue engineering techniques that involve high-pressure or electrical fields during the matrix fabrication process, which are normally not compatible with living cells.…”

Section: The Perspective Of Artificial Cell Mediated-tissue Engineeringmentioning

confidence: 99%

Toward Artificial Cell‐Mediated Tissue Engineering: A New Perspective

Sümbelli,

Mason,

van Hest

2023

Advanced Biology

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The fast‐growing pace of regenerative medicine research has allowed the development of a range of novel approaches to tissue engineering applications. Until recently, the main points of interest in the majority of studies have been to combine different materials to control cellular behavior and use different techniques to optimize tissue formation, from 3‐D bioprinting to in situ regeneration. However, with the increase of the understanding of the fundamentals of cellular organization, tissue development, and regeneration, has also come the realization that for the next step in tissue engineering, a higher level of spatiotemporal control on cell‐matrix interactions is required. It is proposed that the combination of artificial cell research with tissue engineering could provide a route toward control over complex tissue development. By equipping artificial cells with the underlying mechanisms of cellular functions, such as communication mechanisms, migration behavior, or the coherent behavior of cells depending on the surrounding matrix properties, they can be applied in instructing native cells into desired differentiation behavior at a resolution not to be attained with traditional matrix materials.

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Synthetic tissue engineering: Programming multicellular self-organization by designing customized cell-cell communication

Cited by 7 publications

References 56 publications

Global dynamics of microbial communities emerge from local interaction rules

Global dynamics of microbial communities emerge from local interaction rules

Engineered Platforms for Maturing Pluripotent Stem Cell–Derived Liver Cells for Disease Modeling

Toward Artificial Cell‐Mediated Tissue Engineering: A New Perspective

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