Synthetische Versuche zur Darstellung von Derivaten des heterokondensierten, heterocyclischen 1.3‐Triazo‐7.0′‐pyrimidins

Differentiation between [1,2,4]triazolo[1,5‐a] pyrimidine and [1,2,4]triazolo[4,3‐a]‐ pyrimidine regioisomers by 1H15N HMBC experiments

“…As part of our medicinal chemistry programme, we decided to prepare compounds of the parent structure [1,2,4]triazolo[4, 3‐a]pyrimidine ( 2 ). It had been described previously that direct condensation of malonoaldehyde derivatives with either a 3‐amino‐[1,2,4]‐triazole or a 3,5‐diamino‐[1,2,4]‐triazole precursor invariably gives a mixture of the two possible regioisomers 1 and 2 (Scheme ) 8, 13, 18…”

Synthesis, characterization and in vitro cytotoxicity of three types of platinum(II) complexes containing 5,7-diethyl-1,2,4-triazolo[1,5-a]pyrimidine

“…5,7-Diethyl-1,2,4-triazolo[1,5-a]pyrimidine (detp) was prepared according to the method described by Bülow and Haas based on the reaction of 3-amino-1,2,4-triazole with 3,5-heptanedione [27,28].…”

Structure-cytotoxicity relationship for different types of mononuclear platinum(II) complexes with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine

“…K 2 PtCl 4 was prepared from metallic Pt by known procedures [22]. 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidines were prepared according to the method of Bülow and Haas [23] by the reaction of 3-amino-1,2,4-triazole with 2,2,6,6-tetramethyl-3,5-heptanedione [24]. Disilver malate (Ag 2 C 4 H 4 O 5 ) was prepared by the reaction of Ag 2 CO 3 with L(−)-malic acid by a published method [21].…”