Synvisc-One™ for the treatment of knee osteoarthritis

Radecki, Jeffrey; Kim, Susan S.; Vad, Vijay B.

doi:10.2217/ijr.09.54

Cited by 2 publications

(3 citation statements)

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“…Hylan G‐F 20 (Synvisc, Genzyme), consists of two hylan polymers, hylan A and hylan B . Hylan A extracted from rooster combs is pre‐treated with formaldehyde resulting in cross‐link formation between hydroxyl groups on the HA and amino/imino group of proteins between 2 and 8 native HA chains are thus cross‐linked in hylan preparations producing an HA product of ≈6 MDa . The average protein content of hylan A is 0.4–0.8% .…”

Section: Protection Of the Articular Cartilage Surface From Abrasion mentioning

confidence: 99%

“…The average protein content of hylan A is 0.4–0.8% . Hylan B is formed by further cross‐linking of hylan A using divinyl sulfone to form a visc‐oelastic gel with ≈20% divinyl sulfone cross‐links. NASHA (non‐animal stabilized HA) was subsequently developed to provide a high molecular weight cross‐link stabilized HA preparation from a bacterial ferment to avoid any immunological sensitivity issues which have been reported for animal sourced HAs .…”

Section: Protection Of the Articular Cartilage Surface From Abrasion mentioning

confidence: 99%

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Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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The aim of this study is to review developments in glycosaminoglycan and proteoglycan research relevant to cartilage repair biology and in particular the treatment of osteoarthritis (OA). Glycosaminoglycans decorate a diverse range of extracellular matrix and cell associated proteoglycans conveying structural organization and physico-chemical properties to tissues. They play key roles mediating cellular interactions with bioactive growth factors, cytokines, and morphogenetic proteins, and structural fibrillar collagens, cell interactive and extracellular matrix proteoglycans, and glycoproteins which define tissue function. Proteoglycan degradation detrimentally affects tissue functional properties. Therapeutic strategies have been developed to counter these degenerative changes. Neo-proteoglycans prepared from chondroitin sulfate or hyaluronan and hyaluronan or collagen-binding peptides emulate the interactive, water imbibing, weight bearing, and surface lubricative properties of native proteoglycans. Many neo-proteoglycans outperform native proteoglycans in terms of water imbibition, matrix stabilization, and resistance to proteolytic degradation. The biospecificity of recombinant proteoglycans however, provides precise attachment to native target molecules. Visco-supplements augmented with growth factors/therapeutic cells, hyaluronan, and lubricin (orthobiologicals) have the capacity to lubricate and protect cartilage, control inflammation, and promote cartilage repair and regeneration of early cartilage lesions and may represent a more effective therapeutic approach to the treatment of mild to moderate OA and deserve further study.Similar protective perineural net structures assembled from the lectican proteoglycan family and HA also occur in the CNS/PNS. These so called perineuronal nets are visualized by immunolocalization of MAb 1B5 (+) epitope in rat brain (e) and pericellular 1B5(+) epitope expression by isolated neurons (f). Scale bars 100 µm.

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Section: Protection Of the Articular Cartilage Surface From Abrasion mentioning

confidence: 99%

Section: Protection Of the Articular Cartilage Surface From Abrasion mentioning

confidence: 99%

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Hayes

Melrose

2019

Advanced Therapeutics

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“…Between the stance and swing phase conditions, the axial loading of the knee was removed for 20 min to allow for soft tissue relaxation. Following the tests in the native condition, 6 ml HA (Synvisc, Hylan G-F 20, Sanofi-Aventis, GmbH, Frankfurt, Germany, HA concentration: 8 mg/ml; MW: 6000 kDa) were injected into the joint capsule using a 22G syringe (B. Braun Melsungen AG, Germany), which corresponds to a clinical one-time treatment procedure [ 31 ]. The knees were manually flexed and extended five times to homogeneously distribute the HA in the joint.…”

Section: Methodsmentioning

confidence: 99%

Impact of hyaluronic acid injection on the knee joint friction

de Roy,

Eichhorn,

Faschingbauer

et al. 2023

Knee surg. sports traumatol. arthrosc.

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Purpose The purpose of this in vitro study was to investigate whether or not hyaluronic acid supplementation improves knee joint friction during osteoarthritis progression under gait-like loading conditions. Methods Twelve human cadaveric knee joints were equally divided into mild and moderate osteoarthritic groups. After initial conservative preparation, a passive pendulum setup was used to test the whole joints under gait-like conditions before and after hyaluronic acid supplementation. The friction-related damping properties given by the coefficient of friction µ and the damping coefficient c (in kg m2/s) were calculated from the decaying flexion–extension motion of the knee. Subsequently, tibial and femoral cartilage and meniscus samples were extracted from the joints and tested in an established dynamic pin-on-plate tribometer using synthetic synovial fluid followed by synthetic synovial fluid supplemented with hyaluronic acid as lubricant. Friction was quantified by calculating the coefficient of friction. Results In the pendulum tests, the moderate OA group indicated significantly lower c0 values (p < 0.05) under stance phase conditions and significantly lower µ0 (p = 0.01) values under swing phase conditions. No degeneration-related statistical differences were found for µend or cend. Friction was not significantly different (p > 0.05) with regard to mild and moderate osteoarthritis in the pin-on-plate tests. Additionally, hyaluronic acid did not affect friction in both, the pendulum (p > 0.05) and pin-on-plate friction tests (p > 0.05). Conclusion The results of this in vitro study suggested that the friction of cadaveric knee joint tissues does not increase with progressing degeneration. Moreover, hyaluronic acid viscosupplementation does not lead to an initial decrease in knee joint friction.

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Synvisc-One™ for the treatment of knee osteoarthritis

Cited by 2 publications

References 74 publications

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Glycosaminoglycan and Proteoglycan Biotherapeutics in Articular Cartilage Protection and Repair Strategies: Novel Approaches to Visco‐supplementation in Orthobiologics

Impact of hyaluronic acid injection on the knee joint friction

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