Syphilis seroprevalence among HIV-infected males in Istanbul, Turkey

Köksal, Muammer Osman; Beka, Hayati; Evlice, Oğuz; Çıftçı, Sevgi; Başaran, Seniha; Akgül, Baki; Eraksoy, Haluk; Ağaçfidan, Ali

doi:10.1016/j.ram.2020.01.002

Cited by 14 publications

(14 citation statements)

References 24 publications

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“… 18 Yet another study of HIV-infected MSM in Turkey in 2020 reported overall seroprevalence to be 28.7%. 19 Additionally, 1 study of transgender youth in the United States found that 55% of transgender females reported a syphilis diagnosis in their lifetime. 20 Our findings support high rates of lifetime prevalence of syphilis found in MSM and transgender women around the world.…”

Section: Discussionmentioning

confidence: 99%

High Lifetime Prevalence of Syphilis in Men Who Have Sex With Men and Transgender Women Versus Low Lifetime Prevalence in Female Sex Workers in Lima, Peru

Hung

Osias

Konda³

et al. 2020

Sexual Trans Dis

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Section: Discussionmentioning

confidence: 99%

High Lifetime Prevalence of Syphilis in Men Who Have Sex With Men and Transgender Women Versus Low Lifetime Prevalence in Female Sex Workers in Lima, Peru

Hung

Osias

Konda³

et al. 2020

Sexual Trans Dis

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“…Pese a que, en la literatura científica nacional, no se dispone de investigaciones comparables, en otros países se cuenta con algunos estudios que muestran una problemática de similar gravedad en varias poblaciones. Así, en 244 sujetos con vih, se halló una prevalencia de infección por T. pallidum del 19,3 %, siendo más afectado el grupo de hsh, en quienes fue del 28,7 % [23]; en 1702 casos de sífilis de un centro diagnóstico de Barcelona, el 93 % correspondió a hsh [24]; otras investigaciones con población institucionalizada demuestran aumento de casos, con mayor afectación de los hsh [25]. En un centro de atención médica analizaron 323 casos de sífilis, de los cuales el 34 % correspondió a hsh [26], y otros autores indican que cerca de un tercio de hsh infectados con vih presentan infección por T. pallidum [27].…”

Section: Discussionunclassified

Prevalencia de infección por Treponema pallidum en individuos atendidos en un centro especializado de Medellín, Colombia

Cardona‐Arias

Higuita-Gutiérrez

Cataño-Correa

2022

Rev. Fac. Nac. Salud Pública

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Objetivo: Describir la prevalencia de infección por Treponema pallidum en individuos atendidos en un centro especializado de Medellín, Colombia, 2019. Metodología: Estudio de corte, con 776 sujetos de población general (aparentemente sanos-asintomáticos y sin factores de riesgo para sífilis), 126 hombres que tienen sexo con hombres (hsh) y 190 jóvenes vulnerables (estrato socioeconómico bajo, desempleados y sin finalizar educación básica), captados intramural y extramuralmente en espacios de concentración de hsh y organizaciones no gubernamentales. Se empleó fuente de información primaria basada en un encuesta y prueba de detección de anticuerpos IgG, IgM e IgA específicos para T. pallidum. Resultados: La prevalencia de infección por T. pallidum fue 0,53 % en jóvenes vulnerables, 2,19 % en población general y 16,67 % en hsh. La razón de odds de infección en los sujetos con edad entre 51-60 años fue 13,8 (IC 95 % = 3,5-51,5) respecto a la hallada en los jóvenes entre 21-30 años; 12,0 (IC 95 % = 1,8-79,2) en quienes no tienen escolaridad frente a los universitarios; 3,3 (IC 95 % = 1,1-9,9) en las personas sin afiliación en salud, comparadas con las del régimen contributivo, y 8,1 (IC 95 % = 2,8-23,0) en quienes tiene relaciones sexuales con grupos clave versus quienes no refieren estas prácticas. Conclusión: Se halló una menor prevalencia de infección por T. pallidum en los jóvenes, seguida de los sujetos de población general y fue mayor en hsh. Se identificaron los grupos de mayor riesgo (entre los tres subgrupos estudiados), que incluyen sujetos excluidos de los programas de prevención, con confluencia de factores de riesgo sexual y privación socioeconómica.

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“…After a long period of declining incidence, syphilis is currently a reemerging disease worldwide, especially between subjects at increased risk of sexually transmitted diseases (STD). Several studies have observed that a high seroprevalence of syphilis is present in HIV-infected patients, in particular among men who have sex with men (MSM) [ 2 ]. A review calculated a 9.5% prevalence of syphilis between HIV-infected subjects [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual clinical manifestation and challenging serological interpretation of syphilis: insights from a case report

et al. 2021

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Background The clinical manifestations of recent syphilis can be variable, with typical and atypical patterns. Several conditions may cause atypical clinical aspects, including human immunodeficiency virus (HIV) co-infection. Besides the clinical features, co-infections may completely alter syphilis serological tests, causing interpretative difficulties and diagnostic delays. Aim of the work is to describe the difficulties encountered during the diagnostic evaluation of atypical skin manifestations and of the serology for syphilis of an HIV-infected patient who had contracted it several times. Case presentation In 2020, a 52-year old HIV-positive bisexual male patient was admitted to our department with a 4-month history of moderately itchy cutaneous lesions localized at his neck, trunk and arms. In 2013, the patient presented with a classic syphilitic roseola of the trunk and a secondary syphilis was diagnosed, with increased levels of rapid plasma reagin (RPR), Treponema pallidum hemagglutination assay (TPHA), anti-Treponema pallidum IgM and IgG Index. A second episode occurred in 2018, as a primary syphilis with multiple ulcerative lesions of the penis, and increased levels of RPR, IgG and IgM. In 2019, a further episode of secondary syphilis was treated with Doxycycline. In 2020, erythematous and papular lesions with vesicular components and urticarial erythema multiforme (EM)-like lesions were present at the neck, trunk and arms. Serological tests and Nucleic Acid Amplification Test (NAAT) for Treponema Pallidum were performed, as well as a cutaneous biopsy with histological and immunohistochemical evaluation of one lesion. NAAT was negative for T. pallidum. Serological test results were discordant with a new syphilis infection, showing only increased levels of RPR and anti-Treponema IgG. The cutaneous biopsy revealed a non specific histological pattern, while the immunohistochemical evaluation with anti-spirochetal antibodies was mandatory for the diagnosis of recent syphilis, showing clusters of rod-shaped elements, some of which with spiral form, focally present at the epidermis and adnexal structures. Conclusions Nowadays, syphilis may present with atypical clinical and serological features. Physicians should be aware of these possible alterations and consider syphilis even in case of uncommon clinical aspect and unclear serological tests. Cutaneous biopsy and immunohistochemical exam may be mandatory for the diagnosis.

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Syphilis seroprevalence among HIV-infected males in Istanbul, Turkey

Cited by 14 publications

References 24 publications

High Lifetime Prevalence of Syphilis in Men Who Have Sex With Men and Transgender Women Versus Low Lifetime Prevalence in Female Sex Workers in Lima, Peru

High Lifetime Prevalence of Syphilis in Men Who Have Sex With Men and Transgender Women Versus Low Lifetime Prevalence in Female Sex Workers in Lima, Peru

Prevalencia de infección por Treponema pallidum en individuos atendidos en un centro especializado de Medellín, Colombia

Unusual clinical manifestation and challenging serological interpretation of syphilis: insights from a case report

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